β-FIBRINOGEN PROMOTER -455 G/A(HaeIII)POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE

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β-FIBRINOGEN PROMOTER -455 G/A(HaeIII)POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE

中国医学科学杂志（英文版） 2004年0卷第1期页码：1-5

Updated：2024-04-10

- β-FIBRINOGEN PROMOTER -455 G/A(HaeIII)POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE
- Affiliations：
  
  1. Bi Sheng1,2*,Wang Desheng1,Li Guozhong1,Wen Shirong1,and Pan Shangha2Institute of Cerebrovascular Diseases and Related Disorders,1Department of Neurology, 2Central Laboratory, the First Clinical College of Harbin Medical University,Harbin,150001
  2. Department of Neurology
  3. the First Clinical College of Harbin Medical University
  4. Central Laboratory
  5. the First Clinical College of Harbin Medical University Harbin,150001
  6. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号： R743
- 纸质出版日期：2004
- Accepted：
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β-FIBRINOGEN PROMOTER -455 G/A(HaeIII)POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE[J]. 中国医学科学杂志（英文版）, 2004,0(1):1-5.

β-FIBRINOGEN PROMOTER -455 G/A（HaeIII）POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE[J]. Chinese medical sciences journal, 2004, 0(1): 1-5.
β-FIBRINOGEN PROMOTER -455 G/A(HaeIII)POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE[J]. 中国医学科学杂志（英文版）, 2004,0(1):1-5. DOI：

β-FIBRINOGEN PROMOTER -455 G/A（HaeIII）POLYMORPHISM PREDICTION OF PLASMA FIBRINOGEN BUT NOT OF ISCHEMIC CEREBROVASCULAR DISEASE[J]. Chinese medical sciences journal, 2004, 0(1): 1-5. DOI：

摘要

Abstract

Objective The -455 G/A（HaeIII）polymorphism of β-fibrinogen gene influences levels of plasma fibrinogen. We further investigated whether it influences the risk of ischemic cerebrovascular disease. Methods We accumulated 134 acute ischemic cerebrovascular disease（ICVD）cases and compared their -455 G/A status with a control group（n = 166）. The β-fibrinogen gene -455 G/A polymorphism was analyzed for all subjects by PCR-RFLP with the restrictive enzyme HaeIII. Results Plasma fibrinogen was higher in AA homozygous participants（341 mg/dL）than in partici-pants carrying the G allele: GA（290 mg/dL）

GG（298 mg/dL）in the control group. Plasma fibrinogen was also higher in AA homozygous patients（353 mg/dL）than in cases carrying the G allele: GA（287 mg/dL）

GG（302 mg/dL）in the ICVD group. However

there was no significant association between β-fibrinogen gene -455 G/A polymorphism and ICVD group. Conclusions Although a small effect cannot be excluded

β-fibrinogen gene -455 G/A polymor-phism is an independent predictor of plasma fibrinogen

but not of ischemic cerebrovascular disease.

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