Objective.To introduce the properties of Chinese type A botulinum toxin（CBTXA

made by Lanzhou Institute of Biological Products）

and its long?term effect for focal dystonia and hemifacial spasm.Method.The purity and recovery of crude and crystalline toxin were tested.Long?term data from305patients with hemifacial spasm（HFS）

blepharospasm（BS）and cervical dystonia（CD）were evalu-ated and subgroups of patients received CBTXA injections between1994and2000in at least six sepa-rate treatment sessions

with follow up for2～8years.The therapeutic results of the last session CBTXA injections were analyzed in comparison with the first session.Result.CBTXA purity was high[（2.55～2.60）×10 7 LD50/mgPr

A260/A280≤0.55

high molecular substance accounted for99.2%of total proteins].Long term treatment with CBTXA in patients with focal dystonia and HFS was not associated with any decline in benefit

and efficacy may improve slightly with repeat treatments.CBTXA is an excellent long-term treatment of HFS

BS and CD.Conclusion.We conclude that Chinese type A botulinum toxin is of botulinum toxin therapy quality standard according to results obtained from the basic study and long?term clinical applications.The re?injection of CBTXA significantly improves the quality of life of most patients and is a safe

effective and comparatively economical treatment for patients with focal dystonia and HFS.