ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN

Your Location：

Home >

Browse articles >

ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN

中国医学科学杂志（英文版） 2003年0卷第4期页码：222-225

Updated：2024-04-10

- ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN
- Affiliations：
  
  1. Li Mei 1,,Meng Xunwu 1 ,Zhou Xueying 1 ,Xing Xiaoping 1 and Yu Wei 2 1 Department of Endocrinology,2 Department of Radiology,Peking Union Medical College Hospital ,CAMS &PUMC,Beijing,100730
  2. CAMS &PUMC
  3. ,China
  4. Department of Radiology
- Author bio：
- Funds：
- DOI：
  中图分类号： R58
- 纸质出版日期：2003
- Accepted：
Scan QR Code
ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN[J]. 中国医学科学杂志（英文版）, 2003,0(4):222-225.

ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN[J]. Chinese medical sciences journal, 2003, 0(4): 222-225.
ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN[J]. 中国医学科学杂志（英文版）, 2003,0(4):222-225. DOI：

ASSOCIATION OF PARATHYROID HORMONE GENE POLYMORPHISM WITH BONE MINERAL DENSITY IN CHINESE WOMEN[J]. Chinese medical sciences journal, 2003, 0(4): 222-225. DOI：

摘要

Abstract

Objective.To investigate the distribution frequency of parathyroid hormone（PTH）gene polymorphism in healthy adults from Bejing area and to explore the association of PTH genotypes with bone mineral density（BMD）.Methods.PTH gene polymorphism was detected in270subjects by polymerase chain reaction（PCR）and PCR /restriction fragment length polymorphism（PCR /RFLP）.The digestion products of restriction enzyme Bst B1were separated on1%agarose gels.PTH genotypes were confirmed by DNA sequences analysis.BMD was measured by dual-energy X-ray absorptiometry（DEXA

DPX -L

Lunar）.Results.Genotype frequencies of BB

bb were73.7%

25.9%and0.4%respectively in Beijing adults（P<0.01）

67.1%

32.2%and0.7%in postmenopausal women

which was different from Japanese wom-en.We statistically compared bone mineral density at the lumbar2-4and proximal femur between BB and Bb genotypes.No obvious association was found between the BMD and PTH genotypes in Beijing women（P>0.05）.Conclusion.PTH gene polymorphism is not associated with BMD in Chinese women.The further research to explore the genetic risk factors of osteoporosis should be committed.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

ASSOCIATION ANALYSIS OF POLYMORPHISMS OF ACE GENE AND AGT GENE WITH ESSENTIAL HYPERTENSION IN CHINESE HAN'S POPULATION

EFFECTS OF VITAMIN D RECEPTOR GENE POLYMORPHISMS ON SUSCEPTIBILITY TO TYPE 1 DIABETES MELLITUS

Endothelial nitric oxide synthase gene polymorphisms associated with susceptibility to high altitude pulmonary edema in Chinese railway construction workers at Qinghai-Tibet over 4 500 meters above sea Level