Objective To assess the influence of mimic cardiac rate on hydrodynamics of different mechanical prosthetic cardiac valves. Methods US-made CarboMedics bileaflet valve

China-made Jiuling bileaflet valve and C-L tilting disc valve were tested via a pulsatile flow simulator in the aortic position. Testing conditions were set at mimic cardiac rates of 55 bpm

75 bpm

100 bpm with a constant mimic cardiac output of 4 L/min. The mean pressure differences （ΔP）

leakage volumes （LEV） and closing volumes （CLV） across each valve

and effective orifice areas （EOA） were analyzed. Results Within physiological range

ΔP

LEV

and CLV decreased as mimic cardiac rate increased

with a large extent of variance. EOA increased along with an increase in mimic cardiac rate. It was a different response in terms of cardiac rate alteration for different types of mechanical prosthetic cardiac valves. Conclusion Mimic cardiac rate change affects hydrodynamics of mechanical prosthetic cardiac valves. Within physiological range

the hydrodynamic of prosthetic bileaflet valve is better than that of tilting disc valve.