DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N<sup>ω</sup>-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS

石彦荣; 齐永芬; 卜定方; 蒋宏峰; 王冬艳; 高霖; 庞永正; 唐朝枢

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DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS

中国医学科学杂志（英文版） 2003年0卷第4期页码：199-205

Updated：2024-04-10

- DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS
- Affiliations：
  
  1. Institute of Cardiovascular Disease Research
  2. Peking University First Hospital
  3. Beijing100034Institute of Cardiovascular Research
  4. Peking University Health Science Center
  5. ,China
- Author bio：
- Funds：
  
  ThisworkwassupportedbyTheMajorBasicResearchPro-gramofChina(G200056905).
- DOI：
  中图分类号： R541.3
- 纸质出版日期：2003
- Accepted：
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石彦荣, 齐永芬, 卜定方, 等. DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS[J]. 中国医学科学杂志（英文版）, 2003,0(4):199-205.

DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS[J]. Chinese medical sciences journal, 2003, 0(4): 199-205.
石彦荣, 齐永芬, 卜定方, 等. DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS[J]. 中国医学科学杂志（英文版）, 2003,0(4):199-205. DOI：

DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS[J]. Chinese medical sciences journal, 2003, 0(4): 199-205. DOI：

摘要

Abstract

Objective.To study the change of taurine transport

and taurine transporter（TAUT）and cysteine sulfinate decarboxylase（CSD）mRNA contents in hypertension and hypertensive cardiomegaly.Methods.Taurine content was determined with a amino acid analyser.Taurine uptakes were deter-mined by（ 3 H）-taurine incubation.The content of TAUT and CSD mRNA levels were measured by com-petitive quantitative RT-PCR in myocardial and vascular tissues of L-N ω -nitro-arginine（L-NNA）-in-duced hypertensive rats.Results.After the treatment of rats with L-NNA for28days

myocardial and vascular taurine con-tents decreased by11%and15%（P<0.05）

respectively

and plasma taurine level increased by13%（P<0.05）.Myocardial and vascular Vmax of taurine uptake reduced by30%and19%（P<0.05）

respec-tively.Their Km of taurine uptake increased by36%and17%（P<0.05）.Myocardial and vascular TAUT mRNA content decreased by22%and19%（P<0.05）

respectively

but CSD mRNA content increased by22%（P<0.05）and30%（P<0.01）

respectively.Conclusions.This study suggests that there is a decreased taurine content in myocardial and vascu-lar tissues of L-NNA-induced hypertension rats.The decreased taurine content may result from the de-creased number of TAUT on the cell membrane mainly due to the down-regulation of TAUT gene and TAUT affinity caused by hypertension and hypertensive cardiomegaly.

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DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-Nω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS

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DYSFUNCTION OF MYOCARDIAL AND VASCULAR TAURINE TRANSPORT IN L-N^ω-NITRO-ARGININE-INDUCED HYPERTENSIVE RATS