ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N<sup>5</sup>, N<sup>10</sup> -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION

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ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION

中国医学科学杂志（英文版） 2002年0卷第4期页码：231-235

Updated：2024-04-10

- ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION
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  中图分类号： R743.3
- 纸质出版日期：2002
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ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION[J]. 中国医学科学杂志（英文版）, 2002,0(4):231-235.

ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION^△[J]. Chinese medical sciences journal, 2002, 0(4): 231-235.
ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION[J]. 中国医学科学杂志（英文版）, 2002,0(4):231-235. DOI：

ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION^△[J]. Chinese medical sciences journal, 2002, 0(4): 231-235. DOI：

摘要

<正>To investigate the relationship of plasma homocysteine (Hcy) level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis - ultraviolet detection and the gene polymorphism of N5

N10 - methylenetetrahydrofolate reductase (MTHFR) was studied with PCR-RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients (19. 3 ± 6. 0 μ mol/L) was markedly higher than that of the controls (13. 7 ± 5. 4μ mol/L) (t = 4. 16

P < 0. 001). There are 3 genotypes

C/C

C/T and T/T

about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However

the frequencies of each genotype and allele were not significantly different between the patients and the controls.Conclusions. The elevated plasma Hcy level is a risk factor for atherothrombotic cerebral infarction

and is related t

Abstract

Objective. To investigate the relationship of plasma homocysteine （Hcy） level to stroke and genetic factor to elevated plasma Hcy level.Methods. The plasma Hcy level was measured by capillary electrophoresis - ultraviolet detection and the gene polymorphism of N5

N10 - methylenetetrahydrofolate reductase （MTHFR） was studied with PCR-RFLP assay in 43 patients with cortical cerebral infarction and 42 healthy controls.Results. The plasma Hcy level of the patients （19. 3 ± 6. 0 μ mol/L） was markedly higher than that of the controls （13. 7 ± 5. 4μ mol/L）（t = 4. 16

P < 0. 001）. There are 3 genotypes

C/C

C/T and T/T

about base - variation of MTHFR gene at locus 677. The plasma Hcy level of the subjects with T/T genotype was higher than that of subjects with other genotypes. However

and is related to the C→T mutation at locus 677 of MTHFR gene.

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ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N5, N10 -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION

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ASSOCIATION OF PLASMA HOMOCYSTEINE LEVEL AND N⁵, N¹⁰ -METHYLENETETRAHYDROFOLATE REDUCTASE GENE POLYMORPHISM WITH CEREBRAL INFARCTION