THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA

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THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA

中国医学科学杂志（英文版） 2003年0卷第4期页码：248-253

Updated：2024-04-10

- THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA
- Affiliations：
  
  1. Gao Jinming ,Lin Yaoguang,Qiu Changchun ,Liu Yiwen ,Ma Yi and Liu Ying Department of Respiratory Disease,PUMC Hospital,CAMS &PUMC,Beijing100730 National Laboratory of Medical Molecular Biology,Institute of Basic Medical Science,CAMS & PUMC,Beijing,100005
  2. PUMC Hospital
  3. CAMS & PUMC
  4. ,China
  5. National Laboratory of Medical Molecular Biology
  6. Institute of Basic Medical Science
- Author bio：
- Funds：
- DOI：
  中图分类号： R562.25
- 纸质出版日期：2003
- Accepted：
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THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA[J]. 中国医学科学杂志（英文版）, 2003,0(4):248-253.

THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA[J]. Chinese medical sciences journal, 2003, 0(4): 248-253.
THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA[J]. 中国医学科学杂志（英文版）, 2003,0(4):248-253. DOI：

THE ASSOCIATION BETWEEN TUMOR NECROSIS FACTORαGENE POLYMORPHISM AND ASTHMA[J]. Chinese medical sciences journal, 2003, 0(4): 248-253. DOI：

摘要

Abstract

Objective.In this study

we investigated the hypothesis that tumor necrosis factor（TNF）α-308gene polymorphism might be of the genetic predisposition to asthma and asthma phenotypes.Methods.TNFα-308gene polymorphism was genotyped in221random unrelated Northern Chinese population（comprising125asthmatics and96healthy controls）and52individuals from12asthmatic families with Han ethnic by using polymerase chain reaction（PCR）-restriction fragment length polymor-phism（RFLP）.Methacholine（Mch）broncho-challenge test

bronchial reversibility test and lung function were underwent in all asthmatics.Results.TNFα-3082homozygosity was present at a significantly higher frequency in asthmatics than that in controls（20.8%vs11.4%

P<0.05

OR2.259）

the TNF allele2was also higher in asthmatics compared with controls（0.42vs0.33

P<0.01）.TNFα-3082homozygosity was an weak independent risk factor for asthma etiology（OR0.226

P<0.05）.Moreover

patients carrying TNFα-3082homozy-gosity had less responsive to inhaledβ 2 -agonist in20minutes than patients carrying other two genotypes（24.1%vs29.5%vs38.8%

P<0.05）.Linkage analysis didn’t support that TNFαgene was linked to asthma （Likelihood of odds

LOD<1）based on familial data.Conclusion These results suggest that TNFα-3082homozygosity may be of a component contribut-ing to the genetic predisposition to asthma

and airway responsiveness toβ2 -agonist.

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