CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA

丁学琴; 刘贵明; 王俊科; 盛卓人

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CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA

中国医学科学杂志（英文版） 2003年第1期页码：50-53

Updated：2024-04-10

- CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA
- Affiliations：
  
  1. Department of Anesthesiology and ICU
  2. the First Affiliated Hospital
  3. China Medical University
  4. China Medical University Shenyang,110001
- Author bio：
- Funds：
- DOI：
  中图分类号： R363
- 纸质出版日期：2003
- Accepted：
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[1]丁学琴,刘贵明,王俊科,盛卓人.CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA[J].Chinese Medical Sciences Journal,2003(01):50-53.

CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA[J]. Chinese medical sciences journal, 2003, (1): 50-53.
[1]丁学琴,刘贵明,王俊科,盛卓人.CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA[J].Chinese Medical Sciences Journal,2003(01):50-53. DOI：

CHANGE OF CARBON MONOXIDE IN PLASMA AND TISSUE DURING ACUTE HYPOXIA[J]. Chinese medical sciences journal, 2003, (1): 50-53. DOI：

摘要

<正> Objective. To investigate the role of endogenous carbon monoxide （CO） in hypoxia.Methods. After rats were inhaled with hypoxic gases and the heme oxygenase inhibitor ZnPPIX was administered

we measured the CO levels in plasma

liver

lung and kidney. Meanwhile plasma cGMP levels were observed. Furthermore

we recorded the changes of hemodynamic and blood gases.Results. Acute mild hypoxia （10% O2） significantly increased CO levels in plasma as well as liver

kidney and lung

while acute severe hypoxia （5% O2） significantly decreased CO levels in plasma as well as liver

kidney and lung. In addition

the former significantly elevated cGMP levels in plasma while the latter markedly reduced cGMP levels in plasma. The hemodynamic changes occurred in accordance with the changes of carbon monoxide.Conclusions. Our results indicate

for the first time

that the endogenous carbon monoxide plays an important role in regulating the vessel tone during hypoxia.

Abstract

Objective. To investigate the role of endogenous carbon monoxide （CO） in hypoxia.Methods. After rats were inhaled with hypoxic gases and the heme oxygenase inhibitor ZnPPIX was administered

we measured the CO levels in plasma

liver

lung and kidney. Meanwhile plasma cGMP levels were observed. Furthermore

we recorded the changes of hemodynamic and blood gases.Results. Acute mild hypoxia （10% O2） significantly increased CO levels in plasma as well as liver

kidney and lung

while acute severe hypoxia （5% O2） significantly decreased CO levels in plasma as well as liver

kidney and lung. In addition

for the first time

that the endogenous carbon monoxide plays an important role in regulating the vessel tone during hypoxia.

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