STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADULTS

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STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADULTS

中国医学科学杂志（英文版） 2002年0卷第2期页码：73-76

Updated：2024-04-10

- STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADULTS
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  中图分类号： R587.1
- 纸质出版日期：2002
- Accepted：
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STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADULTS[J]. 中国医学科学杂志（英文版）, 2002,0(2):73-76.

STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADU LTS[J]. Chinese medical sciences journal, 2002, 0(2): 73-76.
STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADULTS[J]. 中国医学科学杂志（英文版）, 2002,0(2):73-76. DOI：

STUDY ON THE RELATIONSHIP BETWEEN MITOCHONDRIAL GENE MUTATION AND LATENT AUTOIMMUNE DIABETES MELLITUS IN ADU LTS[J]. Chinese medical sciences journal, 2002, 0(2): 73-76. DOI：

摘要

Abstract

Objective.To identify the A3243G mutation of mi tochondrial（mt ）DNA in patients with latent autoimmu ne diabetes mellitus in adults（LADA）of Han nationality in the northeast a rea of China.Methods.Seventy-nine diabetics of Han natio nality

whose families have resided in the northeast area of China for more than 3generations

we re divided into 3groups:Group 1（22cases of type 2diabetes with mater-nal inheritance history）

Group 2（34cases of LADA）

Group 3（23cases of type 1diabetes in adolesc ents）.The A3243G of mt DNA was detected in th ese 79subjects with the method of PCR-RFLP.Results.None of the 79diabetics studied was p ositively identified for the A3243G mutation of mt DNA.Conclusion.The A3243G mutation of mt DNA might not be related to the onset of LADA in dia betic popula-tion of Han nationality in northeast area of China and there might not be close relationship between A3243G mut a-tion of mt DNA and autoimmunity.

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THE STUDY ON AUTOIMMUNE PATHOLOGY IN OSTEOARTHRITIS