NITRIC  OXIDE  INHIBITS  A  RISE  OF  ATP-INTRODUCED    CYTOSOLIC  FREE  Ca<sup>2+</sup>  CONCENTRATION  AND  RELEASE    FROM INTRACELLULAR  STORED  Ca<sup>2+</sup>

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NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺

中国医学科学杂志（英文版） 2000年0卷第4期页码：217-221

Updated：2024-04-10

- NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺
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- Author bio：
- Funds：
  
  TheprojectwassupportedbytheNationalScienceFoundationofChina( 39570 2 74 )
- DOI：
  中图分类号： R363
- 纸质出版日期：2000
- Accepted：
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NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺[J]. 中国医学科学杂志（英文版）, 2000,0(4):217-221.

NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺[J]. Chinese medical sciences journal, 2000, 0(4): 217-221.
NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺[J]. 中国医学科学杂志（英文版）, 2000,0(4):217-221. DOI：

NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺[J]. Chinese medical sciences journal, 2000, 0(4): 217-221. DOI：

摘要

Abstract

Object. The effects of ATP-introduced a rise in cytosolic free Ca2+ concentration and inhibition of nitric oxide were investigated. Method. Measurement of free Ca2+（[Ca2+] i）of cultured rat tail arterial smooth muscle cells using Fura-2/AM dual excitation wavelength spectrofluorometer. Results. There are two components of [Ca2+] i can be evoked by ATP. One part is Ca2+ entry from Ca2+ channel and formed a plateau. The another part is a peak that released from Ca2+ store. Both of them can be inhibited by NO. Conclusion. The ATP induced [Ca2+] i rise that release Ca2+ from both Insp 3 and ryanochine receptors and Ca2+ entry through calcium channels. The inhibition of NO on ATP induced [Ca2+] i rise that was mediated by cGMP.

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NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca2+ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca2+

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摘要

Abstract

关键词

Keywords

references

NITRIC OXIDE INHIBITS A RISE OF ATP-INTRODUCED CYTOSOLIC FREE Ca²⁺ CONCENTRATION AND RELEASE FROM INTRACELLULAR STORED Ca²⁺