ROLE OF  ENDOGENOUS CARBON  MONOXIDE IN ENDOTOXIN  SHOCK

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ROLE OF ENDOGENOUS CARBON MONOXIDE IN ENDOTOXIN SHOCK

中国医学科学杂志（英文版） 2000年0卷第2期页码：98-102

Updated：2024-04-10

- ROLE OF ENDOGENOUS CARBON MONOXIDE IN ENDOTOXIN SHOCK
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  中图分类号： R364.14
- 纸质出版日期：2000
- Accepted：
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ROLE OF ENDOGENOUS CARBON MONOXIDE IN ENDOTOXIN SHOCK[J]. 中国医学科学杂志（英文版）, 2000,0(2):98-102.

ROLE OF ENDOGENOUS CARBON MONOXIDE IN ENDOTOXIN SHOCK[J]. Chinese medical sciences journal, 2000, 0(2): 98-102.
ROLE OF ENDOGENOUS CARBON MONOXIDE IN ENDOTOXIN SHOCK[J]. 中国医学科学杂志（英文版）, 2000,0(2):98-102. DOI：

ROLE OF ENDOGENOUS CARBON MONOXIDE IN ENDOTOXIN SHOCK[J]. Chinese medical sciences journal, 2000, 0(2): 98-102. DOI：

摘要

Abstract

Objective.To study the role of endogenous carbon monoxide （CO） in endotoxin shock. Methods. The changes of CO levels and the effects of zinc protoporphyrin IX （ZnPP）

an inhibitor of hemeoxygenase （HO）

in endotoxin shock and the efficacy of hemin

an inducer of HO were investigated. Results.The plasma CO levels were found to be significantly increased during the course of endotoxin shock. Injection of ZnPP was shown to abrogate the endotoxininduced hypotension and metabolic derangements markedly. Administration of hemin to healthy rabbits revealed the hypotension and metabolic derangements similar to the animals given endotoxin. Conclusion.CO is a newly found endogenously produced mediator which may play an important role in the pathogenesis of endotoxin shock.

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关联资源

EVIDENCE OF INCREASED ENDOGENOUS CARBON MONOXIDE PRODUCTION IN NEWBORN RAT ENDOTOXICOSIS

ENDOGENOUS HEME OXYGENASE/CARBON MONOXIDE SYSTEM MEDIATES LIPOPOLYSACCHARIDE-INDUCED INTUSSUSCEPTION IN RATS