Objective. To study the changes of microcirculation in patients with diabetic retinopathy（DR）. Methods. Examination were performed in 153 cases of type Ⅱ diabetes mellitus

among them

72 cases were male

81 cases were female

mean age 57.0±10.0 years

mean disease course 8.2±7.5 years. All cases were examined fundi by ophthalmologist

urinary albumin excretion rate （UAE） in 24 hours was measured by radioimmunoassay. Moreover

we examined the blood glucose

blood pressure

blood viscosity and observed the changes of naifold microcirculation. Results.It was found that there were more evident disturbance of microcirculation

markedly slowed velocity of blood flow（P<0.05）

significantly increased aggregation of blood cells（P<0.05） and exudation around the loop（P<0.05） in the group with DR

compared with the group without DR. Conclusion. It was more evident disturbance of nailfold microcirculation in patients with diabetic retinopathy.