REDUCED　TUMORIGENICITY　OF　METASTATIC　HUMAN　LUNG　CANCER　CELL　SUBLINE（PGCL3）　TRANSFECTED　WITH　hRARβ　GENE

朱伟勇; 吴秉铨; 郑杰; 方伟岗; 王洁良; 由江峰

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REDUCED　TUMORIGENICITY　OF　METASTATIC　HUMAN　LUNG　CANCER　CELL　SUBLINE（PGCL3）　TRANSFECTED　WITH　hRARβ　GENE

中国医学科学杂志（英文版） 1996年第1期

Updated：2024-04-10

- REDUCED　TUMORIGENICITY　OF　METASTATIC　HUMAN　LUNG　CANCER　CELL　SUBLINE（PGCL3）　TRANSFECTED　WITH　hRARβ　GENE
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  中图分类号： R363
- 纸质出版日期：1996
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[1]朱伟勇,吴秉铨,郑杰,方伟岗,王洁良,由江峰.REDUCED　TUMORIGENICITY　OF　METASTATIC　HUMAN　LUNG　CANCER　CELL　SUBLINE（PGCL3）　TRANSFECTED　WITH　hRARβ　GENE[J].Chinese Medical Sciences Journal,1996(01):13-16.

REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE （PGCL3）TRANSFECTED WITH hRAR βGENE[J]. Chinese medical sciences journal, 1996, (1).
[1]朱伟勇,吴秉铨,郑杰,方伟岗,王洁良,由江峰.REDUCED　TUMORIGENICITY　OF　METASTATIC　HUMAN　LUNG　CANCER　CELL　SUBLINE（PGCL3）　TRANSFECTED　WITH　hRARβ　GENE[J].Chinese Medical Sciences Journal,1996(01):13-16. DOI：

REDUCED TUMORIGENICITY OF METASTATIC HUMAN LUNG CANCER CELL SUBLINE （PGCL3）TRANSFECTED WITH hRAR βGENE[J]. Chinese medical sciences journal, 1996, (1). DOI：

摘要

ＲＥＤＵＣＥＤＴＵＭＯＲＩＧＥＮＩＣＩＴＹＯＦＭＥＴＡＳＴＡＴＩＣＨＵＭＡＮＬＵＮＧＣＡＮＣＥＲＣＥＬＬＳＵＢＬＩＮＥ（ＰＧＣＬ３）ＴＲＡＮＳＦＥＣＴＥＤＷＩＴＨｈＲＡＲβＧＥＮＥＺｈｕＷｅｉｙｏｎｇ朱伟勇；ＷｕＢｉｎｇｑｕａｎ吴秉铨；ＺｈｅｎｇＪｉ...

Abstract

The recombinant PSG5-RARβ plasmid and the G418-resistant PSV2neo Plasmid （ 10 : 1） were cotransfected into PGCL3 cells by copreciprtation with calcium phosphate. The transfectants CR3 and CR4

which expressed the RARβ gene. were identified by Northern blot hybridization. The results showed that the in vitro growth and invasion of CR3 and CR4 were dramatically reduced compared to the control-transfected cell （CSV1）. Furthermore

the colony-forming abilities in soft agar and the tumorigenicrty in nude mice of CR3 and CR4 were abrogated. Our results suggests that RARβ functions not only as a receptor mediating the RA action

but also as a suppressor in lung tumorigenesis.

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