THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE

Your Location：

Home >

Browse articles >

THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE

中国医学科学杂志（英文版） 1997年0卷第3期页码：139-142

Updated：2024-04-10

- THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE
- Affiliations：
- Author bio：
- Funds：
- DOI：
  中图分类号： R392.2
- 纸质出版日期：1997
- Accepted：
Scan QR Code
THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE[J]. 中国医学科学杂志（英文版）, 1997,0(3):139-142.

THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE[J]. Chinese medical sciences journal, 1997, 0(3): 139-142.
THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE[J]. 中国医学科学杂志（英文版）, 1997,0(3):139-142. DOI：

THE MECHANISM OF INHIBITION OF DNA SYNTHESIS BY HHO7A,ADERIVATIVE OF HAINANENSINE[J]. Chinese medical sciences journal, 1997, 0(3): 139-142. DOI：

摘要

Abstract

The synthesis Of DNA

RNA and protein in L121O cells was inhibited by HHO7A in a dose-dependentand time-dependent way. HHO7A shOwed much stronger inhibitory effect on [3H]-thymidine incorporationthan that on [3H]-uridine or [3H]-tyrosine incorporation. The methods of shift of absorption spectrum

shift of fluorescence emission spectrum and excitation spectrum

and isotope technique were used to investigate the mechanism of actiOn of HHO7A on DNA synthesis. The results suggested thaT the action ofHHO7A on DNA synthesis was nOt probably due to direct damage to the DNA template

it might mainlyact by interfering with the metabolism of DNA.

关键词

Keywords

references

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据