Objectives’ To observe the effects of reflux esophagitis（RE） on the lung function and alrway reactivity

and study the mechanism of airway hyperresponsiveness（AHR） in patients with RE.Methods. Lung function measurements and airway provocation tests were performed in 31 RE patientsand 35 control subjects’ TXB

and PGF

. were determined in 20 cases of each group.Results. In RE patients the lung function was lower and the rate of AHR was higher than control sub-jects （P<0. 05）. Among RE patients 25 % had higher airway sensitivity （Dminr 3u ）. The TXB2 of REpatients with AHR was higher than those without AHR’ Dmin correlated significantly with TXB2 （r=0. 653

P<0. 05）.Concluswhs’ RE could damage the lung function. The rate of AHR was 61 %

the high airway sensltivity was probably potential asthma

and TXB2 may play a role in the pathogenesis of AHR.