This study focused on the influences of opioids on the generation of antibody against sheep erythrocyte in vitro

It was found that morphine. a-CAO

DADLE

MENK were able to inhibit the capacity of murine spleen cells to generate antibody and leukotriene C4 and conversely. dynorphin was able to stimulate the capacity of murine spleen cells to generate antibody and leukotriene C4. Morphine

a-CAO

MENK

DADLE

dynorphin decreased intracellular cAMP level

increased [Ca（2+）]i and calmodulin activity. The effects were completely blocked by naloxone

the specific opioid antagonist. Our results showed that opioids regulate the production of antibody in murine spleen cells

and alter intracellular cAMP

[Ca（2+）]i calmodulin activity. and leukotriene C4 production by way of binding to different receptor types.