RESEARCH ON THE ESTIMATE OF SAFETY AND TOXICITY OF P-NITROPHENOL SODIUM WITHA PHYSIOLOGICALLY BASED PHARMACOKINETICS MODEL

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中国医学科学杂志（英文版） 1997年0卷第1期页码：32-36

Updated：2024-04-10

- RESEARCH ON THE ESTIMATE OF SAFETY AND TOXICITY OF P-NITROPHENOL SODIUM WITHA PHYSIOLOGICALLY BASED PHARMACOKINETICS MODEL
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  中图分类号： R99
- 纸质出版日期：1997
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RESEARCH ON THE ESTIMATE OF SAFETY AND TOXICITY OF P-NITROPHENOL SODIUM WITHA PHYSIOLOGICALLY BASED PHARMACOKINETICS MODEL[J]. 中国医学科学杂志（英文版）, 1997,0(1):32-36.

RESEARCH ON THE ESTIMATE OF SAFETY AND TOXICITY OF P-NITROPHENOL SODIUM WITH A PHYSIOLOGICALLY BASED PHARMACOKINETICS MODEL[J]. Chinese medical sciences journal, 1997, 0(1): 32-36.
RESEARCH ON THE ESTIMATE OF SAFETY AND TOXICITY OF P-NITROPHENOL SODIUM WITHA PHYSIOLOGICALLY BASED PHARMACOKINETICS MODEL[J]. 中国医学科学杂志（英文版）, 1997,0(1):32-36. DOI：

RESEARCH ON THE ESTIMATE OF SAFETY AND TOXICITY OF P-NITROPHENOL SODIUM WITH A PHYSIOLOGICALLY BASED PHARMACOKINETICS MODEL[J]. Chinese medical sciences journal, 1997, 0(1): 32-36. DOI：

The safety and toxicity of chemicals given first to animals and finally to humans are generally estimated with a method of safe coefficient

which is scientifically a way lack of grounds. To make a change of the old method

we designed a Physiologically Based Pharmacokinetics Medel for the estimate of safety and toxicity of chemicais. As an example

p-nitrophenol sodium （PNP-Na） is used in the research work. Studies of the PNP-Na pharmacokinetics in bodies of rat as well as humans are made

and possibilities of making use of the Model in the estimate of safety and toxicity of chemicals are discussed.

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