In this study

we investigated the effect of captopril（CPT） on glomerular filtration rate（GFR）

effective renal plasma flow（ERPF）

filtration fraction（FF）

urinary albumin excretion（UAE） and daily urinary excretion of thromboxane B2（TXB2） and 6-keto-prostaglandin F1a（6-keto-PGFla） in 29 normotensive non-insulin-dependent diabetes（NIDDM） patients without clinically discernible nephropathy.Before treatment

urinary excretion 6-keto-PGF1a was significantly increased（P<0.05） in 29 NIDDM patients compared with 25 health subjects matched for age and sex.The values of GFR and FF were significantly higher（P<0.01 and P<0.005

respectively） in NIDDM than in normal volunters

whereas ERPF was comparable in both groups.Meanwhile we observed that UAE of early NIDDM was increased before treatment.After CPT treatment

GFR

FF

UAE and urinary excretion of 6-keto-PGFla were significantly reduce（all P<0.005） compared with those of NIDDM before treatment. These data indicated that CPT is effective in lowering glomerular filtration pressure and ameliorating microalbuminuria in the normotensive early NIDDM.