TREATMENT　OF　23　PATIENTS　WITH　ADVANCED　GASTRIC　CANCER　BY　INTRAVENOUSLY　TRANSFER　OF　AUTOLOGOUS　TUMOR－INFILTRATING　LYMPHOCYTES

许祥裕; 徐立春; 丁树标; 吴明生; 唐治华; 伏文钧; 倪庆

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TREATMENT　OF　23　PATIENTS　WITH　ADVANCED　GASTRIC　CANCER　BY　INTRAVENOUSLY　TRANSFER　OF　AUTOLOGOUS　TUMOR－INFILTRATING　LYMPHOCYTES

中国医学科学杂志（英文版） 1995年第3期

Updated：2024-04-10

- TREATMENT　OF　23　PATIENTS　WITH　ADVANCED　GASTRIC　CANCER　BY　INTRAVENOUSLY　TRANSFER　OF　AUTOLOGOUS　TUMOR－INFILTRATING　LYMPHOCYTES
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  中图分类号： R735.2
- 纸质出版日期：1995
- Accepted：
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[1]许祥裕,徐立春,丁树标,吴明生,唐治华,伏文钧,倪庆.TREATMENT　OF　23　PATIENTS　WITH　ADVANCED　GASTRIC　CANCER　BY　INTRAVENOUSLY　TRANSFER　OF　AUTOLOGOUS　TUMOR－INFILTRATING　LYMPHOCYTES　[J].Chinese Medical Sciences Journal,1995(03):185-187.

TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR-INFILTRATING LYMPHOCYTES COMBINED WITH rIL-2[J]. Chinese medical sciences journal, 1995, (3).
[1]许祥裕,徐立春,丁树标,吴明生,唐治华,伏文钧,倪庆.TREATMENT　OF　23　PATIENTS　WITH　ADVANCED　GASTRIC　CANCER　BY　INTRAVENOUSLY　TRANSFER　OF　AUTOLOGOUS　TUMOR－INFILTRATING　LYMPHOCYTES　[J].Chinese Medical Sciences Journal,1995(03):185-187. DOI：

TREATMENT OF 23 PATIENTS WITH ADVANCED GASTRIC CANCER BY INTRAVENOUSLY TRANSFER OF AUTOLOGOUS TUMOR-INFILTRATING LYMPHOCYTES COMBINED WITH rIL-2[J]. Chinese medical sciences journal, 1995, (3). DOI：

摘要

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Abstract

Tumor-infiltrating lymphocytes （TIL）isolated from metastatic lymph nodes in patients with nonoperable advanced gastric cancer were induced to become LAK-like cytotoxic activrty of TIL after in vitro culture with rlL-2.Twenty-three patients with advanced gastric cancer were treated by intravenously transfer of autologous TIL combined with rlL-2. The tumor forus disappeared （complete remission

CR） in 3 patients （13. 0%） and significantly decreased （partial remission

PR） in 5 patients （21. 7%）. Fifteen patients did not respond to the treatment. The amount of soluable IL-2 receptor in serum was significantly decreased after treatment

the cytotoxicity of NK cells and OT test were significantly increased. No significant difference in CD4/CD8 was found between before and after treatment. No serious side effect was obseved in the treatment.

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