INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES

严缘昌; 梁平; 王琳芳; 缪时英; Samuel S.Koide

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INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES

中国医学科学杂志（英文版） 1990年第1期页码：9-12

Updated：2024-04-10

- INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES
- Affiliations：
  
  1. Population Council Center for Biomedical Research,New York
  2. Institute of Basic Medical Sciences
  3. CAMS
  4. ,China
  5. Population Council Center for Biomedical Research
- Author bio：
- Funds：
  
  Supported by Rockefeller Foundation Grant and Mellon Foundation Grant
- DOI：
  中图分类号：
- 纸质出版日期：1990
- Accepted：
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[1]严缘昌,梁平,王琳芳,缪时英,Samuel S.Koide.INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES[J].Chinese Medical Sciences Journal,1990(01):9-12.

INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES[J]. Chinese medical sciences journal, 1990, (1): 9-12.
[1]严缘昌,梁平,王琳芳,缪时英,Samuel S.Koide.INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES[J].Chinese Medical Sciences Journal,1990(01):9-12. DOI：

INHIBITION OF ZYGOTE FORMATION AND EMBRYO DEVELOPMENT IN MICE IMMUNIZED WITH MONOCLONAL ANTISPERM ANTIBODIES[J]. Chinese medical sciences journal, 1990, (1): 9-12. DOI：

摘要

<正> Passive immunization of female mice by the intraperitoneal administration of ascitic fluidscontaining monoclonal antisperm antibodies blocked the development of mouse zygotes tomorulae and blastocysts when cultured in vitro.Radioiodinated YWK-I monoclonal anti-bodies were prepared and administered intraperitoneally to Jemale mice.Significant radioac-tivity was found in washes of the oviductal lumens.The results suggest that antispermantibodies block fertilization and may have a deleterious effect on early developing embryos.

Abstract

Passive immunization of female mice by the intraperitoneal administration of ascitic fluids containing monoclonal antisperm antibodies blocked the development of mouse zygotes to morulae and blastocysts when cultured in vitro.Radioiodinated YWK-I monoclonal anti- bodies were prepared and administered intraperitoneally to Jemale mice.Significant radioac- tivity was found in washes of the oviductal lumens.The results suggest that antisperm antibodies block fertilization and may have a deleterious effect on early developing embryos.

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