EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM

李箭; 汪钟

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EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM

中国医学科学杂志（英文版） 1990年第1期页码：47-50

Updated：2024-04-10

- EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM
- Affiliations：
  
  1. PUMC Student
  2. Institute of Basic Medical Sciences CAMS
  3. ,China
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版日期：1990
- Accepted：
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[1]李箭,汪钟.EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM[J].Chinese Medical Sciences Journal,1990(01):47-50.

EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM[J]. Chinese medical sciences journal, 1990, (1): 47-50.
[1]李箭,汪钟.EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM[J].Chinese Medical Sciences Journal,1990(01):47-50. DOI：

EFFECTS OF NIMODIPINE ON PLATELET AGGREGATION AND THE ACTIVITY OF ENZYMES IN ARACHIDONIC ACID METABOLISM[J]. Chinese medical sciences journal, 1990, (1): 47-50. DOI：

摘要

正

The effects of nimodipine on platelet aggregation and arachidonic acid（AA）metabolismwere studied in order to explore its effect on patients with thrombosis or cardiovas-cular disease.The results indicate that nimodipine（50-350μmol/L）significantly inhibitsplatelet aggregation induced by ADP

and ionophore A23187 in a dose dependentmanner.The inhibitory effects induced by ionophore A23187 could be partially antagonizedby calcium（1 mmol/L）.When the substrate was AA and the enzyme was supplied bypig lung microsomes

nimodipine（50-400μmol/L）significantly reduced the generation ofTXB

and 6-keto-PGF

in parallel.When the substrate was prostaglandin endoperoxide

however

the levels of TXB

and 6-keto-PGF

were not significantly altered in the sameconcentration range.The results suggest that nimodipine is a cyclooxygenase inhibitor

andits ability to inhibit platelet aggregation is related to its calcium blocking effect.

Abstract

The effects of nimodipine on platelet aggregation and arachidonic acid（AA）metabolism were studied in order to explore its effect on patients with thrombosis or cardiovas- cular disease.The results indicate that nimodipine（50-350μmol/L）significantly inhibits platelet aggregation induced by ADP

and ionophore A23187 in a dose dependent manner.The inhibitory effects induced by ionophore A23187 could be partially antagonized by calcium（1 mmol/L）.When the substrate was AA and the enzyme was supplied by pig lung microsomes

nimodipine（50-400μmol/L）significantly reduced the generation of TXB

and 6-keto-PGF

in parallel.When the substrate was prostaglandin endoperoxide

however

the levels of TXB

and 6-keto-PGF

were not significantly altered in the same concentration range.The results suggest that nimodipine is a cyclooxygenase inhibitor

and its ability to inhibit platelet aggregation is related to its calcium blocking effect.

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