ORAL　TRANSMUCOSAL　BACK　PERMEATION　OF　ALFENTANIL　IN　DOGS──A　NOVEL　METHOD　TO　DETERMINE　BLOOD　ALFENTANIL　CONCENTRATION

牛苏毅; 张洁; 黄宇光

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ORAL　TRANSMUCOSAL　BACK　PERMEATION　OF　ALFENTANIL　IN　DOGS──A　NOVEL　METHOD　TO　DETERMINE　BLOOD　ALFENTANIL　CONCENTRATION

中国医学科学杂志（英文版） 1994年第4期

Updated：2024-04-10

- ORAL　TRANSMUCOSAL　BACK　PERMEATION　OF　ALFENTANIL　IN　DOGS──A　NOVEL　METHOD　TO　DETERMINE　BLOOD　ALFENTANIL　CONCENTRATION
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  中图分类号： R363
- 纸质出版日期：1994
- Accepted：
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[1]牛苏毅,张洁,黄宇光.ORAL　TRANSMUCOSAL　BACK　PERMEATION　OF　ALFENTANIL　IN　DOGS──A　NOVEL　METHOD　TO　DETERMINE　BLOOD　ALFENTANIL　CONCENTRATION[J].Chinese Medical Sciences Journal,1994(04):233-236.

Niu Suyi, Zhang Jie, Huang Yuguang and T.H.Stanley. ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION[J]. Chinese medical sciences journal, 1994, (4).
[1]牛苏毅,张洁,黄宇光.ORAL　TRANSMUCOSAL　BACK　PERMEATION　OF　ALFENTANIL　IN　DOGS──A　NOVEL　METHOD　TO　DETERMINE　BLOOD　ALFENTANIL　CONCENTRATION[J].Chinese Medical Sciences Journal,1994(04):233-236. DOI：

Niu Suyi, Zhang Jie, Huang Yuguang and T.H.Stanley. ORAL TRANSMUCOSAL BACK PERMEATION OF ALFENTANIL IN DOGS──A NOVEL METHOD TO DETERMINE BLOOD ALFENTANIL CONCENTRATION[J]. Chinese medical sciences journal, 1994, (4). DOI：

摘要

ＯＲＡＬＴＲＡＮＳＭＵＣＯＳＡＬＢＡＣＫＰＥＲＭＥＡＴＩＯＮＯＦＡＬＦＥＮＴＡＮＩＬＩＮＤＯＧＳＡ──ＡＮＯＶＥＬＭＥＴＨＯＤＴＯＤＥＴＥＲＭＩＮＥＢＬＯＯＤＡＬＦＥＮＴＡＮＩＬＣＯＮＣＥＮＴＲＡＴＩＯＮ￥ＮｉｕＳｕｙｉ（牛苏毅），ＺｈａｎｇＪｉｅ(...

Abstract

This study explores a novel noninvasive method for monitoring blood alfentanil concentrations using a dog model. Alfentanil which "back"

permeated across the oral mucosa from the systemic circulation was collected from the oral mucosal surface and quantitated. The levels of the "back" permeated alfentanil were found to closely reflect real time serum alfentanil concentrations. With further work

this finding may lead to a novel noninvasive method for monitoring real time serum alfentanil concentrations in its clinical applications.

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