人类免疫缺陷病毒-1感染急性期双侧面神经麻痹合并脑膜炎1例

吴焱; 宋歌; 魏春波; 伦文辉

doi:10.24920/003460

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人类免疫缺陷病毒-1感染急性期双侧面神经麻痹合并脑膜炎1例

中国医学科学杂志（英文版） 2019年34卷第1期页码：55-59

Case Reports | Updated：2024-04-10

- 人类免疫缺陷病毒-1感染急性期双侧面神经麻痹合并脑膜炎1例
- Affiliations：
  
  1. Department of Dermatology and Venereology, Beijing Ditan Hospital Affiliated to Capital Medical University, Beijing 100015, China
  2. Infectious Disease Center, Peking University Ditan Teaching Hospital, Beijing 100015, China
- Author bio：
  
  * Tel: 86-10-84323095, E-mail: lunwenhui@163.com lunwenhui@163.com
- Funds：
  
  Supported by the Beijing Health System High-level Health Technology Talents Training Program((2014-3-094))
- DOI：10.24920/003460
  中图分类号：
- 收稿日期：2018-02-02，
  
  修回日期：2019-02-22，
  
  网络出版日期：2019-03-30，
  
  纸质出版日期：2019-03-30
- Accepted：
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吴焱, 宋歌, 魏春波, 等. 人类免疫缺陷病毒-1感染急性期双侧面神经麻痹合并脑膜炎1例[J]. 中国医学科学杂志（英文版）, 2019,34(1):55-59.

Wu Yan, Song Ge, Wei Chunbo, et al. Bilateral Peripheral Facial Paralysis Combined with HIV Meningitis During Acute HIV-1 Infection: A Case Report[J]. Chinese medical sciences journal, 2019, 34(1): 55-59.
吴焱, 宋歌, 魏春波, 等. 人类免疫缺陷病毒-1感染急性期双侧面神经麻痹合并脑膜炎1例[J]. 中国医学科学杂志（英文版）, 2019,34(1):55-59. DOI： 10.24920/003460.

Wu Yan, Song Ge, Wei Chunbo, et al. Bilateral Peripheral Facial Paralysis Combined with HIV Meningitis During Acute HIV-1 Infection: A Case Report[J]. Chinese medical sciences journal, 2019, 34(1): 55-59. DOI： 10.24920/003460.

摘要

本研究报道了1例人类免疫缺陷病毒(HIV)感染出现双侧周围性面神经麻痹的病例。一名38岁的男性同性恋患者因双侧面瘫来我院就诊，入院前21天，患者出现高热(达39℃)、畏寒、头痛、疲劳、全身不适、恶心、呕吐等症状。神经系统检查显示:双侧周围性面神经麻痹，双唇和双侧脸颊下垂，双眼睑闭合不全。脑脊液检查结果显示：细胞数增多，微量总蛋白含量显著升高，脑脊液中鞘内IgG合成明显增多。ELISA初筛检测显示HIV-1血清学呈阳性，Western blot进一步确认了阳性结果。CD4

细胞计数为180/mm

。脑脊液病毒载量为血浆病毒载量的10倍。患者的健康状况不断改善，双侧面神经麻痹于2个月后完全缓解。

Abstract

Here we reported a Chinese case of bilateral peripheral facial paralysis (PFP) in human immunodeficiency virusc (HIV) infected population. A 38-year-old homosexual male patient was referred to our hospital for bilateral facial paralysis. 21 days prior to admission he had developed high fever

chills

headache

fatigue

general malaise

nausea and vomiting. Neurological examination revealed bilateral ptosis of lower lip and cheeks

as well as failure of bilateral eyes closure. Analysis of cerebrospinal fluid (CSF) revealed pleocytosis

a marked rise of micro total protein and a marked rise of intrathecal lgG synthesis. The result of HIV-1 serology was positive by ELISA and that was confirmed by western blot. His CD4

cell count was 180 cells/mm

. HIV-1 viral load in CSF was almost 10 times higher than that in plasma. The patient’s condition improved steadily and experienced complete resolution of bilateral PFP after 2 months.

关键词

Keywords

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