EB病毒感染后瑞氏综合征伴多器官功能障碍的一例重症病例

刘秉楠; 齐莹

doi:10.24920/003536

Your Location：

Home >

Browse articles >

EB病毒感染后瑞氏综合征伴多器官功能障碍的一例重症病例

中国医学科学杂志（英文版） 2019年34卷第4期页码：297-299

Case Report | Updated：2024-04-10

- EB病毒感染后瑞氏综合征伴多器官功能障碍的一例重症病例
- Affiliations：
  
  Virology Lab, the Shengjing Hospital of China Medical University, Shenyang, 110004 China
- Author bio：
  
  *,E-mail: qiyingying163@163.com; Tel: 86-18940258925.
- Funds：
- DOI：10.24920/003536
  中图分类号：
- 收稿日期：2018-11-12，
  
  录用日期：2019-4-15，
  
  网络出版日期：2019-12-06，
  
  纸质出版日期：2019-12-06
- Accepted：
Scan QR Code
刘秉楠, 齐莹. EB病毒感染后瑞氏综合征伴多器官功能障碍的一例重症病例[J]. 中国医学科学杂志（英文版）, 2019,34(4):297-299.

Liu Bingnan, Qi Ying. A Severe Case of Reye’s Syndrome with Multiorgan Dysfunction after Epstein-Barr Virus Infection[J]. Chinese medical sciences journal, 2019, 34(4): 297-299.
刘秉楠, 齐莹. EB病毒感染后瑞氏综合征伴多器官功能障碍的一例重症病例[J]. 中国医学科学杂志（英文版）, 2019,34(4):297-299. DOI： 10.24920/003536.

Liu Bingnan, Qi Ying. A Severe Case of Reye’s Syndrome with Multiorgan Dysfunction after Epstein-Barr Virus Infection[J]. Chinese medical sciences journal, 2019, 34(4): 297-299. DOI： 10.24920/003536.

摘要

一名20个月大的男婴在爱泼斯坦-巴尔病毒（Epstein-Barr virus

EBV）感染后进展为瑞氏综合征并伴有多器官功能障碍。患儿同时罹患急性肝衰竭

危及生命的脑水肿

严重的弥散性血管内凝血以及心肌受累。EBV感染在本例加重了瑞氏综合征的疾病进展。患儿尽管接受了全面的支持和对症治疗

仍未免于死亡。本文报告的重症病例提示儿科医生应注意重度EBV感染的多器官受累。

Abstract

A 20-month-old male infant with multiorgan dysfunction after Epstein-Barr virus (EBV) infection developed Reye’s syndrome. He also suffered from acute liver failure

life-threatening cerebral edema

severe disseminated intravascular coagulation (DIC)

and myocardial involvement. EBV infection aggravated the progress of Reye’s syndrome

leading to death despite full supportive and symptomatic therapy. This critical case suggested that pediatricians should pay attention to multiorgan involvement of severe EBV infection.

关键词

Keywords

references

Gosalakkal JA , Kamoji V . Reye syndrome and reye-like syndrome . Pediatr Neurol 2008 ; 39 ( 6 ): 198 - 200 . doi: 10.1016/j.pediatrneurol.2008.06.003 1001-9294-34-4-297/j.pediatrneurol.2008.06.003 .

Center for Disease Control and Prevention. Reye syndrome . 1990 case definition. National Notifiable Diseases Surveillance System (NNDSS) . https://wwwn.cdc.gov/nndss/conditions/reye-syndrome/case-definition/1990/ https://wwwn.cdc.gov/nndss/conditions/reye-syndrome/case-definition/1990/ https://wwwn.cdc.gov/nndss/conditions/reye-syndrome/case-definition/1990/ . Accessed August 13 , 2018 .

Feng LF , Chen XH , Li DX , et al . Reye syndrome and sudden death symptoms after oral administration of nimesulide due to upper respiratory tract infection in a boy . Chin J Contemp Pediatr 2018 ; 20 ( 11 ): 944 -9. Chinese.

Belay ED , Bresee JS , Holman RC , et al . Reye’s syndrome in the United States from 1981 through 1997 . N Engl J Med 1999 ; 340 ( 19 ): 1377 - 82 . doi: 10.1056/NEJM199905063401801 1001-9294-34-4-297/NEJM199905063401801 .

Tsai MH , Hsu CY , Yen MH , et al . Epstein-Barr virus-associated infectious mononucleosis and risk factor analysis for complications in hospitalized children . J Microbiol Immunol Infect 2005 ; 38 ( 9 ): 255 - 61 .doi: 10.1016/S0011-2275(99)00084-3 1001-9294-34-4-297/S0011-2275(99)00084-3 .

Kofteridis DP , Koulentaki M , Valachis A , et al . Epstein Barr virus hepatitis . Eur J Intern Med 2011 ; 22 ( 6 ): 73 - 6 . doi: 10.1097/01.smj.0000216469.04854.2a 1001-9294-34-4-297/01.smj.0000216469.04854.2a .

Calistri E , Tiribelli M , Battista M , et al . Epstein-Barr virus reactivation in a patient treated with anti-thymocyte globulin for severe aplastic anemia . Am J Hematol 2006 ; 81 ( 5 ): 355 - 7 . doi: 10.1002/ajh.20560 1001-9294-34-4-297/ajh.20560 .

Berry PA , Bernal W , Pagliuca A , et al . Multiple organ failure and severe bone marrow dysfunction in two 18 year-old Caucasian patients: Epstein-Barr virus and the haemophagocytic syndrome . Anaesthesia 2008 ; 63 ( 16 ): 1249 - 54 . doi: 10.1111/j.1365-2044.2008.05584.x 1001-9294-34-4-297/j.1365-2044.2008.05584.x .

Rafailidis PI , Mavros MN , Kapaskelis A , et al . Antiviral treatment for severe EBV infections in apparently immunocompetent patients . J Clin Virol 2010 ; 49 ( 7 ): 151 - 7 . doi: 10.1016/j.jcv.2010.07.008 1001-9294-34-4-297/j.jcv.2010.07.008 .

Likic R , Kuzmanic D . Severe thrombocytopenia as a complication of acute Epstein-Barr virus infection . Wien Klin Wochenschr 2004 ; 116 ( 16 ): 47 - 50 . doi: 10.1007/bf03040424 1001-9294-34-4-297/bf03040424 .

M. George . Hemophagocytic lymphohistiocytosis: review of etiologies and management . J Blood Med 2014 ; 5 ( 5 ): 69 - 86 . doi: 10.2147/JBM.S46255 1001-9294-34-4-297/JBM.S46255 .

Klein S , Schmidt C , La Rosée P , et al . Fulminant gastrointestinal bleeding caused by EBV-triggered hemophagocytic lymphohistiocytosis: report of case . Zeitschrift fur Gastroenterologie 2014 ; 52 ( 4 ): 354 - 9 . doi: 10.1055/s-0034-1366154 1001-9294-34-4-297/s-0034-1366154 .

浏览量

577

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据