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妊娠引起的噬血细胞性淋巴组织细胞增生症：病例报告与文献回顾
- Affiliations：
1. 1Department of Medical Oncology, State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021, China
2. 2Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China
- Author bio：
* E-mail: qzf301@sohu.com; Tel: 86-17801204737.
- Funds：
DOI：10.24920/003603
中图分类号：收稿日期：2019-05-08，
录用日期：2019-9-6，
网络出版日期：2020-12-31，
纸质出版日期：2020-12-31
- Accepted：
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赵杰, 杨翼萌, 明树红. 妊娠引起的噬血细胞性淋巴组织细胞增生症：病例报告与文献回顾[J]. 中国医学科学杂志（英文版）, 2020,35(4):371-376.
Zhao Jie, Yang Yimeng, Ming Shuhong. Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review[J]. Chinese medical sciences journal, 2020, 35(4): 371-376.
赵杰, 杨翼萌, 明树红. 妊娠引起的噬血细胞性淋巴组织细胞增生症：病例报告与文献回顾[J]. 中国医学科学杂志（英文版）, 2020,35(4):371-376. DOI： 10.24920/003603.
Zhao Jie, Yang Yimeng, Ming Shuhong. Pregnancy-Induced Hemophagocytic Lymphohistiocytosis: A Case Report and Literature Review[J]. Chinese medical sciences journal, 2020, 35(4): 371-376. DOI： 10.24920/003603.
摘要
噬血细胞性淋巴组织细胞增生症（hemophagocytic lymphohistiocytosis
HLH）是一种罕见但严重威胁健康的疾病
其典型特征为免疫反应失调和过度的炎症反应。目前关于妊娠引起的HLH鲜有报道。本文报道了一例自怀孕17周以来持续发烧21天的30岁孕妇
通过一系列详尽的检查排除感染、自身免疫性疾病和恶性肿瘤等可能病因
给予广谱抗生素和地塞米松等治疗后
病情仍在进展。患者被诊断为妊娠引起的HLH。终止妊娠并继续使用糖皮质激素控制过度炎症反应后
该患者疾病痊愈。妊娠引起的HLH若不及时给予有效的治疗
会严重威胁生命健康。进一步研究以提高HLH早期诊断和病因鉴定至关重要。
Abstract
Hemophagocytic lymphohistiocytosis (HLH) is a rare but devastating disease characterized by dysregulated immune response and hyperinflammation. To our knowledge
pregnancy-induced HLH has been rarely reported in the literature. A 30-year-old pregnant woman presented persistent fever for 21 days since 17 weeks of pregnancy. The possible etiologies such as infection
autoimmune disorder
and malignancy had been ruled out based on a series of exhaustive examinations. The disease progressed despite the use of broad-spectrum antibiotics and dexamethasone. The patient was diagnosed as pregnancy-induced HLH
and finally recovered completely after termination of pregnancy by caesarean and the continuous use of glucocorticoid which played a crucial part in controlling hyperinflammation. Pregnancy-induced HLH could be fatal if effective treatment was not initiated timely. Further studies are needed to improve early diagnosis and etiology identification of HLH.
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references
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