原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告

张傲利; 陈晓娟; 李占奇; 竺晓凡

doi:10.24920/003653

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原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告

中国医学科学杂志（英文版） 2020年35卷第2期页码：186-190

病例报告 | Updated：2024-04-10

- 原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告
- Affiliations：
  
  1a. Department of Pediatric Hematology, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
  1b. Department of Pathology; State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin 300020, China
  2. Department of Hematology, the Second Hospital of Shanxi Medical University, Taiyuan 030001, China
- Author bio：
  
  **,E-mail: xfzhu1981@126.com; Tel: 86-022-23909001. The reported case was from the affiliated hospital of corresponding author.
- Funds：
- DOI：10.24920/003653
  中图分类号：
- 收稿日期：2019-08-15，
  
  录用日期：2019-8-30，
  
  网络出版日期：2020-06-14，
  
  纸质出版日期：2020-06-14
- Accepted：
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张傲利, 陈晓娟, 李占奇, 等. 原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告[J]. 中国医学科学杂志（英文版）, 2020,35(2):186-190.

Zhang Aoli, Chen Xiaojuan, Li Zhanqi, et al. Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report[J]. Chinese medical sciences journal, 2020, 35(2): 186-190.
张傲利, 陈晓娟, 李占奇, 等. 原始神经外胚层肿瘤作为长期存活的急性淋巴细胞白血病儿童的第二恶性肿瘤：病例报告[J]. 中国医学科学杂志（英文版）, 2020,35(2):186-190. DOI： 10.24920/003653.

Zhang Aoli, Chen Xiaojuan, Li Zhanqi, et al. Primitive Neuroectodermal Tumor as the Second Malignant Neoplasm in a Long-Term Survivor Child of Acute Lymphoblastic Leukemia: A Case Report[J]. Chinese medical sciences journal, 2020, 35(2): 186-190. DOI： 10.24920/003653.

摘要

急性淋巴细胞白血病是一种常见的儿童肿瘤。第二恶性肿瘤在长期存活的急性淋巴细胞白血病患儿中极少见

且预后差。我们报告一位初诊并接受无放射治疗急性淋巴细胞白血病的10岁女孩

5年后诊断为原始神经外胚层肿瘤（primitive neuroectodermal tumor

PNET)。在急性淋巴细胞白血病存活的儿童中

原始神经外胚层肿瘤是一种非常罕见的继发恶性肿瘤

且容易被误诊

发病机制尚不清楚

预后不良。因此

长期随访存活的急性淋巴细胞白血病儿童是非常必要的。

Abstract

Acute lymphoblastic leukemia (ALL) is a common pediatric cancer. The second malignant neoplasms (SMNs) in long-term survivors of pediatric ALL are relatively rare. Herein we report a 10-year-old girl who was diagnosed as primitive neuroectodermal tumor (PNET) 5 years after the initial diagnosis of ALL with radiotherapy-free treatment. PNET is an exceedingly rare neoplasm in SMNs of survivors of childhood ALL. It is predisposed to be misdiagnosed and the pathogenesis is unclear. The outcome is poor. Long-term follow-up is necessary for the survival children of ALL.

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references

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