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Wnt5a在肿瘤进展中的作用具有争议性
- Affiliations：
1. 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
2. 2Department of Occupational Medicine, the Third Gansu Provincial Hospital, Lanzhou 730000, China
3. 3Pathological Institution of Basic Medical College, Lanzhou University, Lanzhou 730000, China
- Author bio：
* E-mail: zhaofh0931@163.com.
- Funds：Gansu Health and Family Planning Commission Funding;甘肃省卫生行业科研计划项目基金(GSWSKY2018-34)
DOI：10.24920/003659
中图分类号：收稿日期：2019-09-12，
录用日期：2020-2-4，
网络出版日期：2020-12-31，
纸质出版日期：2020-12-31
- Accepted：
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陈旭, 刘红玲, 赵凤辉, 等. Wnt5a在肿瘤进展中的作用具有争议性[J]. 中国医学科学杂志（英文版）, 2020,35(4):357-365.
Chen Xu, Liu Hongling, Zhao Fenghui, et al. Wnt5a Plays Controversial Roles in Cancer Progression[J]. Chinese medical sciences journal, 2020, 35(4): 357-365.
陈旭, 刘红玲, 赵凤辉, 等. Wnt5a在肿瘤进展中的作用具有争议性[J]. 中国医学科学杂志（英文版）, 2020,35(4):357-365. DOI： 10.24920/003659.
Chen Xu, Liu Hongling, Zhao Fenghui, et al. Wnt5a Plays Controversial Roles in Cancer Progression[J]. Chinese medical sciences journal, 2020, 35(4): 357-365. DOI： 10.24920/003659.
摘要
Wnt5a是Wnt家族中一种具有代表性的分子
它通过Wnt非经典途径调控多种细胞功能。虽然Wnt5a在多种病理状态中均有涉及
但其在肿瘤中的作用尚不明确。Wnt5a在肿瘤的作用机制中可能涉及甲基化修饰、不同的mRNA亚型以及调控不同的下游通路。因此
Wnt5a在肿瘤发展起重要作用（侵袭、迁移、增殖、以及上皮-间质转化）
是一个潜在的预后和治疗的生物标志物。
Abstract
Wnt5a is a representative Wnt ligand that regulates multiple cellular functions through the Wnt5a non-classical pathway. Although Wnt5a has been implicated in various pathological conditions
its role in cancer is ambiguous and might involve methyl modifications
distinct mRNA isoforms
as well as different downstream pathways. Therefore
it is an essential factor in cancers’ progression (invasion
migration
proliferation
and epithelial-mesenchymal transition)
and a potential biomarker for prognosis and treatment.
关键词
Keywords
references
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