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探索应用延长至50分钟的钆赛酸二钠增强磁共振T1 Maps评价大鼠肝纤维化模型肝功能的价值：延长的肝胆期可能提供帮助
- Affiliations：
1Department of Radiology,Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
2Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
3Siemens Healthcare Ltd., Beijing 100102, China
- Author bio：
*Xuan Wang, Tel: 86-10-69157438, Fax: 86-10-69155509, E-mail: dr_wangxuan@163.com;
*Zhengyu Jin, Tel: 86-10-69155441, Fax: 86-10-69155442, E-mail: jinzy@pumch.cn
- Funds：National Science Foundation of China(81501446)
DOI：10.24920/003794
中图分类号：收稿日期：2020-09-15，
网络出版日期：2020-12-01，
纸质出版日期：2021-06-30
- Accepted：
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徐佳, 王萱, 金征宇, 等. 探索应用延长至50分钟的钆赛酸二钠增强磁共振T1 Maps评价大鼠肝纤维化模型肝功能的价值：延长的肝胆期可能提供帮助[J]. 中国医学科学杂志（英文版）, 2021,36(2):110-119.
Xu Jia, Wang Xuan, Jin Zhengyu, et al. Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help[J]. Chinese medical sciences journal, 2021, 36(2): 110-119.
徐佳, 王萱, 金征宇, 等. 探索应用延长至50分钟的钆赛酸二钠增强磁共振T1 Maps评价大鼠肝纤维化模型肝功能的价值：延长的肝胆期可能提供帮助[J]. 中国医学科学杂志（英文版）, 2021,36(2):110-119. DOI： 10.24920/003794.
Xu Jia, Wang Xuan, Jin Zhengyu, et al. Assessing Liver Function by T1 Maps on Gd-EOB-DTPA-Enhanced MRI for up to 50 Min in Rat Models of Liver Fibrosis: A Longer Hepatobiliary Time Period may Help[J]. Chinese medical sciences journal, 2021, 36(2): 110-119. DOI： 10.24920/003794.
摘要
目的
探索延长成像时间的钆赛酸二钠（Gd-EOB-DTPA）增强磁共振T1 mapping成像及快速动态增强扫描序列（DCE）、多期肝胆期磁共振成像对于大鼠肝纤维模型肝功能的评价是否存在潜在价值。
方法
40只雄性SD大鼠
分为采用四氯化碳溶液腹腔注射的肝功能损伤组[四氯化碳溶液分别注射4周（
n
=14）、8周（
n
=8）、12周（
n
=8）]以及对照组（
n
=10）。钆赛酸二钠磁共振增强扫描序列包括T1-mapping成像（延至注射对比剂后50分钟）、DCE、以及多期肝胆期成像。测量获得吲哚菁绿15分钟潴留率（ICG R15）。图像分析计算获得影像学参数如T1弛豫时间减低率（ΔT1）、ΔT1减半时间（T
ΔT1 1/2
）、相对强化率（RE）、RE达峰时间（T
max
）、灌注参数等。应用
Pearson
相关性分析比较影像学参数与ICG R15的关系。
结果
30、40、50分钟的ΔT1和ICG R15具有显著正相关性（
r
=0.784
0.653
0.757
P
=0.007
0.041
0.030）。T
ΔT1 1/2
与ICG R15具有显著正相关性（
r
=0.685
P
=0.029）。T
max
与ICG R15具有显著正相关性（
r
=0.532
P
=0.019）。
结论
晚期肝胆期的ΔT1及T
ΔT1 1/2
与肝功能具有中度相关性。延长成像时间的钆赛酸二钠增强磁共振T1 mapping成像及DCE、多期肝胆期磁共振成像对于大鼠肝纤维模型肝功能的评价具有一定价值。
Abstract
Objectives
To investigate whether a longer time period of gadolinium ethoxybenzyl diethylenetriaminepen-taacetic acid (Gd-EOB-DTPA)-enhanced T1 mapping scanning
as well as dynamic contrast-enhanced (DCE) and multiple hepatobiliary phase magnetic resonance imaging (MRI) have the potential to provide information about liver function in rats with liver fibrosis.
Methods
Forty rats were divided into the carbon tetrachloride-induced hepatic injury groups [carbon tetrachloride for four (
n
=14)
eight (
n
=8)
or twelve (
n
=8) weeks] and the control group (
n
=10). Gd-EOB-DTPA-enhanced MRI was performed including T1-mapping (delayed to 50 min)
DCE
and multiple hepatobiliary phases. Indocyanine green retention rate at 15 min (ICG-R15) was determined. Parameters such as T1 reduction rate (ΔT1)
elimination half-life of ΔT1 (T
ΔT1 1/2
)
relative enhancement (RE)
time to maximum RE (T
max
)
and perfusion parameters were calculated.
Pearson
correlation analysis was used for correlation analysis between ICG-R15 and each MRI indices.
Results
ΔT1 at 30
40
and 50 min showed significant positive correlations with ICG-R15 (
r
=0.784
0.653
0.757
P
=0.007
0.041
0.030). T
ΔT1 1/2
showed a significant positive correlation with ICG-R15 (
r
=0.685
P
=0.029). T
max
showed a significant positive correlation with ICG-R15 (
r
=0.532
P
=0.019).
Conclusions
ΔT1 in the late hepatobiliary phase and T
ΔT1 1/2
exhibited moderate correlations with liver function. The longer time period of Gd-EOB-DTPA-enhanced T1 mapping scanning
as well as DCE and multiple hepatobiliary phases
may be of some value for estimating liver function in rats with liver fibrosis.
关键词
Keywords
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