海德综合征与主动脉瓣置换术：已发表文献回顾

李慧利; 林陪双; 姚允泰

doi:10.24920/003881

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海德综合征与主动脉瓣置换术：已发表文献回顾

中国医学科学杂志（英文版） 2021年36卷第4期页码：307-315

Original Articles | Updated：2024-04-10

- 海德综合征与主动脉瓣置换术：已发表文献回顾
- Affiliations：
  
  1. 1Department of Anesthesiology, The First Hospital of Hebei Medical University, Shijiazhuang 050000, China
  2. 2Department of Anesthesiology, Fujian Medical University Affiliated First Quanzhou Hospital, Quanzhou 362000, China
  3. 3Department of Anesthesiology, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China
- Author bio：
  
  *E-mail: yuntaiyao@126.com
- Funds：
- DOI：10.24920/003881
  中图分类号：
- 收稿日期：2021-01-19，
  
  网络出版日期：2021-10-09，
  
  纸质出版日期：2021-12-31
- Accepted：
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李慧利, 林陪双, 姚允泰. 海德综合征与主动脉瓣置换术：已发表文献回顾[J]. 中国医学科学杂志（英文版）, 2021,36(4):307-315.

Li Huili, Lin Peishuang, Yao Yuntai. Aortic Valve Replacement for Patients with Heyde Syndrome: A Literature Review[J]. Chinese medical sciences journal, 2021, 36(4): 307-315.
李慧利, 林陪双, 姚允泰. 海德综合征与主动脉瓣置换术：已发表文献回顾[J]. 中国医学科学杂志（英文版）, 2021,36(4):307-315. DOI： 10.24920/003881.

Li Huili, Lin Peishuang, Yao Yuntai. Aortic Valve Replacement for Patients with Heyde Syndrome: A Literature Review[J]. Chinese medical sciences journal, 2021, 36(4): 307-315. DOI： 10.24920/003881.

摘要

目的

探讨采用主动脉瓣置换术治疗的海德综合征患者的临床特点及结局。

方法

使用检索词“Heyde syndrome”、“gastrointestinal bleeding”、“aortic stenosis”和“surgery”

检索 PubMed、Embase、Ovid、WANFANG、VIP和CNKI等数据库

提取纳入病例报道中的患者生物学特征、主动脉瓣狭窄程度、胃肠道出血部位、手术治疗和预后等临床资料。

结果

纳入的46篇病例报道共包括55例患者

年龄46~87岁。主动脉瓣轻度狭窄1例

中度狭窄1例

重度狭窄42例（余未提及）。胃肠道出血部位分别为结肠（

=8）、空肠（

=6）、回肠（

=4）、盲肠（

=3）、十二指肠（

=3）和多个部位（

=8）;未发现特定出血部位的患者为23例。术前血红蛋白水平为43~117 g/L。16例患者接受高分子量von Willebrand 因子检测

结果显示 1例正常

其余病例均下降。在55例患者中

43例接受经胸主动脉瓣置换术

12例接受经导管主动脉瓣置换术;14例完成机械瓣置换

33例完成生物瓣置换。5例患者出现并发症：1例术后出现瓣周漏和消化道出血

并行二次主动脉瓣置换术;2例患者反复出现胃肠道出血。2例分别因急性硬脑膜下血肿和多器官衰竭死亡。在随访期内

其余患者状况良好。

结论

海德综合征是一种以主动脉瓣狭窄和消化道出血为特征的综合征。主动脉瓣置换术是海德综合征的一种有效治疗方法。

Abstract

Objective

To explore the characteristics and clinical outcomes of patients with Heyde syndrome (HS) who undergo aortic valve replacement (AVR).

Methods

Electronic databases including PubMed

Embase

Ovid

WANFANG

VIP and CNKI were searched to identify all case reports of HS patients undergoing AVR surgery

using different combinations of search terms “Heyde syndrome”

“gastrointestinal bleeding”

“aortic stenosis”

and “surgery”. Three authors independently extracted the clinical data including the patients’ characteristics

aortic stenosis severity

gastrointestinal bleeding sites

surgical treatments and prognosis.

Results

Finally

46 case reports with 55 patients aging from 46 to 87 years

were determined eligible and included. Of them

1 patient had mild aortic stenosis

1 had moderate aortic stenosis

42 had severe aortic stenosis

and 11 were not mentioned. Gastrointestinal bleeding was detected in colon (

=8)

jejunum (

=6)

ileum (

=4)

cecum (

=3)

duodenal (

=3) and multiple sites (

=8). No specific bleeding site was identified in 23 patients. Preoperative hemoglobin level ranged from 43 to 117 g/L. All but one of 16 patients showed decreased level of high molecule weight von Willebrand factor. Of the 55 patients

43 underwent AVR

and 12 received transcatheter AVR. Aortic valves of 14 cases were replaced by mechanical valves

and 33 cases by biological valves. All patients recovered well during the follow-up

except 5 patients. One patient who had perivalvular leakage and gastrointestinal bleeding after AVR underwent the second AVR. Two patients had recurrent gastrointestinal bleeding. Two patients died of life-threatening acute subdural hematoma and multiple organ failure

respectively.

Conclusions

HS is a rare syndrome characterized by aortic stenosis and gastrointestinal bleeding. AVR is an effective treatment for HS.

关键词

Keywords

references

Heyde EC . Gastrointestinal bleeding in aortic stenosis (letter) . N Engl J Med 1958 ; 259 : 196 .

Supino PG , Borer JS , Preibisz J , et al . The epidemiology of valvular heart disease: a growing public health problem . Heart Fail Clin 2006 ; 2 ( 4 ): 379 - 93 . doi: 10.1016/j.hfc.2006.09.010 https://dx.doi.org/10.1016/j.hfc.2006.09.010 . DOI: 10.1016/j.hfc.2006.09.010 http://doi.org/10.1016/j.hfc.2006.09.010 https://linkinghub.elsevier.com/retrieve/pii/S155171360600078X https://linkinghub.elsevier.com/retrieve/pii/S155171360600078X

Vincentelli A , Susen S , Le Tourneau T , et al . Acquired von Willebrand syndrome in aortic stenosis . N Engl J Med 2003 ; 349 ( 4 ): 343 - 9 . doi: 10.1056/ NEJMoa022831 https://dx.doi.org/10.1056/ NEJMoa022831 . DOI: 10.1056/ NEJMoa022831 http://doi.org/10.1056/ NEJMoa022831 http://www.nejm.org/doi/abs/10.1056/NEJMoa022831 http://www.nejm.org/doi/abs/10.1056/NEJMoa022831

Pate GE , Mulligan A . An epidemiological study of Heyde’s syndrome: an association between aortic stenosis and gastrointestinal bleeding . J Heart Valve Dis 2004 ; 13 ( 5 ): 713 - 6 .

Tsuchiya S , Matsumoto Y , Doman T , et al . Disappearance of angiodysplasia following transcatheter aortic valve implantation in a patient with Heyde’s Syndrome: a case report and review of the literature . J Atheroscler Thromb 2020 ; 27 ( 3 ): 271 - 7 . doi: 10.5551/jat.49239 https://dx.doi.org/10.5551/jat.49239 . DOI: 10.5551/jat.49239 http://doi.org/10.5551/jat.49239

Garcia LR , Garzesi AM , Tripoli G , et al . Heyde Syndrome treated by conventional aortic valve replacement . Braz J Cardiovasc Surg 2019 ; 34 ( 5 ): 630 - 2 . doi: 10.21470/1678-9741-2019-0004 https://dx.doi.org/10.21470/1678-9741-2019-0004 . DOI: 10.21470/1678-9741-2019-0004 http://doi.org/10.21470/1678-9741-2019-0004

Mahboobi SK . Heyde’s syndrome and postoperative bleeding after aortic valve replacement—is there a role for prophylactic desmopressin? J Clin Anesth 2019 ; 56 : 142 . doi: 10.1016/j.jclinane.2019.02.002 https://dx.doi.org/10.1016/j.jclinane.2019.02.002 . DOI: S0952-8180(19)30069-8 http://doi.org/S0952-8180(19)30069-8

Mirna M , Lichtenauer M , Theurl T , et al . Transcatheter aortic valve implantation in a patient with suspected hereditary von Willebrand disease and severe gastrointestinal bleeding—a case report . Scott Med J 2019 ; 64 ( 4 ): 142 - 7 . doi: 10.1177/0036933019862155 https://dx.doi.org/10.1177/0036933019862155 . DOI: 10.1177/0036933019862155 http://doi.org/10.1177/0036933019862155 http://journals.sagepub.com/doi/10.1177/0036933019862155 http://journals.sagepub.com/doi/10.1177/0036933019862155

Alshuwaykh O , Krier MJ . A case of Heyde Syndrome with resolution of gastrointestinal bleeding two weeks after aortic valve replacement . Am J Case Rep 2018 ; 19 : 924 - 6 . doi: 10.12659/AJCR.911298 https://dx.doi.org/10.12659/AJCR.911298 . DOI: 10.12659/AJCR.911298 http://doi.org/10.12659/AJCR.911298 https://www.amjcaserep.com/abstract/index/idArt/911298 https://www.amjcaserep.com/abstract/index/idArt/911298

Iijima M , Itoh N , Murase R , et al . A surgical case of aortic stenosis with recurrent gastrointestinal bleeding: Heyde syndrome . Int J Surg Case Rep 2018 ; 53 : 281 - 4 . doi: 10.1016/j.ijscr.2018.10.078 https://dx.doi.org/10.1016/j.ijscr.2018.10.078 . DOI: 10.1016/j.ijscr.2018.10.078 http://doi.org/10.1016/j.ijscr.2018.10.078 https://linkinghub.elsevier.com/retrieve/pii/S2210261218305029 https://linkinghub.elsevier.com/retrieve/pii/S2210261218305029

Achamallah N , Hardwick A . Tavr and heyde: the role of trans-catheter aortic valve replacement in aortic stenosis associated gastrointestinal bleeding . J General Intern Med 2017 ; 32 : 2 .

Akutagawa T , Shindo T , Yamanouchi K , et al . Persistent gastrointestinal angiodysplasia in Heyde’s Syndrome after aortic valve replacement . Intern Med 2017 ; 56 ( 18 ): 2431 - 3 . doi: 10.2169/internalmedicine. 8603-16 https://dx.doi.org/10.2169/internalmedicine. 8603-16 . DOI: 10.2169/internalmedicine. 8603-16 http://doi.org/10.2169/internalmedicine. 8603-16 https://www.jstage.jst.go.jp/article/internalmedicine/56/18/56_8603-16/_article https://www.jstage.jst.go.jp/article/internalmedicine/56/18/56_8603-16/_article

Balbo CP , Seabra LP , Galoro VG , et al . Heyde’s Syndrome and transcatheter aortic valve implantation . Arq Bras Cardiol 2017 ; 108 ( 4 ): 378 - 80 . doi: 10.5935/abc.20160193 https://dx.doi.org/10.5935/abc.20160193 . DOI: 10.5935/abc.20160193 http://doi.org/10.5935/abc.20160193

Giovannini I , Chiarla C , Murazio M , et al . An extreme case of Heyde syndrome . Dig Surg 2006 ; 23 ( 5-6 ): 387 - 8 . doi: 10.1159/000098457 https://dx.doi.org/10.1159/000098457 . DOI: 10.1159/000098457 http://doi.org/10.1159/000098457 https://www.karger.com/Article/FullText/98457 https://www.karger.com/Article/FullText/98457

Iquille J , Nader J , Colpart E , et al . Unusual gastrointestinal bleeding after sutureless aortic valve replacement: a word of caution . Ann Thorac Surg 2017 ; 103 ( 3 ): e225 - e6 . doi: 10.1016/j.athoracsur. 2016.08.073 https://dx.doi.org/10.1016/j.athoracsur. 2016.08.073 . DOI: 10.1016/j.athoracsur. 2016.08.073 http://doi.org/10.1016/j.athoracsur. 2016.08.073 https://linkinghub.elsevier.com/retrieve/pii/S0003497516311419 https://linkinghub.elsevier.com/retrieve/pii/S0003497516311419

Shibamoto A , Kawaratani H , Kubo T , et al . Aortic valve replacement for the management of Heyde Syndrome: a case report . J Nippon Med Sch 2017 ; 84 ( 4 ): 193 - 7 . doi: 10.1272/jnms.84.193 https://dx.doi.org/10.1272/jnms.84.193 . DOI: 10.1272/jnms.84.193 http://doi.org/10.1272/jnms.84.193

Uchida T , Hamasaki A , Ohba E , et al . Life-threatening subdural hematoma after aortic valve replacement in a patient with Heyde syndrome: a case report . J Cardiothorac Surg 2017 ; 12 ( 1 ): 65 . doi: 10.1186/s13019-017-0629-x https://dx.doi.org/10.1186/s13019-017-0629-x . DOI: 10.1186/s13019-017-0629-x http://doi.org/10.1186/s13019-017-0629-x http://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-017-0629-x http://cardiothoracicsurgery.biomedcentral.com/articles/10.1186/s13019-017-0629-x

Huang DJ , Kong LJ , Wu Z . Transcatheter aortic valve implantation in the treatment of Hyde syndrome: a case report . Chin J Intern Med 2016 ; 55 ( 9 ): 721 - 2 . doi: 10.3760/cma.j.issn.0578-1426.2016.09.013 https://dx.doi.org/10.3760/cma.j.issn.0578-1426.2016.09.013 . DOI: 10.3760/cma.j.issn.0578-1426.2016.09.013 http://doi.org/10.3760/cma.j.issn.0578-1426.2016.09.013

Hudzik B , Wilczek K , Gasior M . Heyde syndrome: gastrointestinal bleeding and aortic stenosis . CMAJ 2016 ; 188 ( 2 ): 135 - 8 . doi: 10.1503/cmaj.150194 https://dx.doi.org/10.1503/cmaj.150194 . DOI: 10.1503/cmaj.150194 http://doi.org/10.1503/cmaj.150194 http://www.cmaj.ca/lookup/doi/10.1503/cmaj.150194 http://www.cmaj.ca/lookup/doi/10.1503/cmaj.150194

Wang B , Wang Y , Su ML . Case report of a patient with Heyde syndrome treated by transcatheter aortic valve implantation . Zhonghua Xin Xue Guan Bing Za Zhi 2016 ; 44 ( 3 ): 269 - 70 . doi: 10.3760/cma.j.issn.0253-3758.2016.03.016 https://dx.doi.org/10.3760/cma.j.issn.0253-3758.2016.03.016 . DOI: 10.3760/cma.j.issn.0253-3758.2016.03.016 http://doi.org/10.3760/cma.j.issn.0253-3758.2016.03.016

Perry PA , Atkins BZ , Amsterdam EA . Gastrointestinal bleeding, aortic stenosis, and the hiding culprit . Am J Med 2015 ; 128 ( 8 ): e5 - 6 . doi: 10.1016/j.amjmed. 2015.02.015 https://dx.doi.org/10.1016/j.amjmed. 2015.02.015 . DOI: 10.1016/j.amjmed. 2015.02.015 http://doi.org/10.1016/j.amjmed. 2015.02.015

Benton SM Jr , Kumar A , Crenshaw M , et al . Effect of transcutaneous aortic valve implantation on the Heyde’s syndrome . Am J Cardiol 2014 ; 114 ( 6 ): 953 - 4 . doi: 10.1016/j.amjcard.2014.06.025 https://dx.doi.org/10.1016/j.amjcard.2014.06.025 . DOI: 10.1016/j.amjcard.2014.06.025 http://doi.org/10.1016/j.amjcard.2014.06.025 https://linkinghub.elsevier.com/retrieve/pii/S0002914914013721 https://linkinghub.elsevier.com/retrieve/pii/S0002914914013721

İlkeli E , Albeyoğlu Ş , Çiloğlu U , et al . Heyde’s syndrome . Asian Cardiovasc Thorac Ann 2014 ; 22 ( 5 ): 592 - 4 . doi: 10.1177/0218492313478433 https://dx.doi.org/10.1177/0218492313478433 . DOI: 10.1177/0218492313478433 http://doi.org/10.1177/0218492313478433 http://journals.sagepub.com/doi/10.1177/0218492313478433 http://journals.sagepub.com/doi/10.1177/0218492313478433

Kapila A , Chhabra L , Khanna A . Valvular aortic stenosis causing angiodysplasia and acquired von Willebrand’s disease: Heyde’s syndrome . BMJ Case Rep 2014 ; 2014 : bcr2013201890. doi: 10.1136/bcr-2013-201890 https://dx.doi.org/10.1136/bcr-2013-201890 . DOI: 10.1136/bcr-2013-201890 http://doi.org/10.1136/bcr-2013-201890

Dos Santos VM , Dos Santos LA , Modesto AA , et al . Heyde syndrome in a 71-year-old man who underwent chest radiotherapy at young age . An Sist Sanit Navar 2013 ; 36 ( 2 ): 339 - 45 . doi: 10.4321/s1137-66272013000200020 https://dx.doi.org/10.4321/s1137-66272013000200020 . DOI: 10.4321/s1137-66272013000200020 http://doi.org/10.4321/s1137-66272013000200020

Maor NR . Heyde syndrome: resolution of anemia after aortic valve surgery . Isr Med Assoc J 2013 ; 15 ( 7 ): 387 - 9 .

Negi SI , Xu R , Anand A . Medical image. A murmur and a bleed: the Heyde syndrome . N Z Med J 2013 ; 126 ( 1371 ): 95 - 7 .

Saad RA , Lwaleed BA , Kazmi RS . Gastrointestinal bleeding and aortic stenosis (Heyde syndrome): the role of aortic valve replacement . J Card Surg 2013 ; 28 ( 4 ): 414 - 6 . doi: 10.1111/jocs.12131 https://dx.doi.org/10.1111/jocs.12131 . DOI: 10.1111/jocs.12131 http://doi.org/10.1111/jocs.12131 https://onlinelibrary.wiley.com/doi/10.1111/jocs.12131 https://onlinelibrary.wiley.com/doi/10.1111/jocs.12131

Godino C , Pavon AG , Mangieri A , et al . Aortic valvuloplasty as bridging for TAVI in high-risk patients with Heyde’s Syndrome: a case report . Case Rep Med 2012 ; 2012 : 946764 . doi: 10.1155/2012/946764 https://dx.doi.org/10.1155/2012/946764 . DOI: 10.1155/2012/946764 http://doi.org/10.1155/2012/946764

Gül M , Sürgit Ö , Özal E , et al . Treatment of aortic valve stenosis and gastrointestinal bleeding by transcatheter aortic valve implantation in Heyde syndrome . Anadolu Kardiyol Derg 2012 ; 12 ( 8 ): 691 - 3 . doi: 10.5152/akd.2012.224 https://dx.doi.org/10.5152/akd.2012.224 . DOI: 10.5152/akd.2012.224 http://doi.org/10.5152/akd.2012.224

Michot JM , Treton X , Brink C , et al . Severe gastro-intestinal angiodysplasia in context of Heyde’s syndrome durably cured after aortic valve replacement . Presse Med 2012 ; 41 ( 7-8 ): 763 - 6 . doi: 10.1016/j.lpm.2011.10.012 https://dx.doi.org/10.1016/j.lpm.2011.10.012 . DOI: 10.1016/j.lpm.2011.10.012 http://doi.org/10.1016/j.lpm.2011.10.012 https://linkinghub.elsevier.com/retrieve/pii/S0755498211005586 https://linkinghub.elsevier.com/retrieve/pii/S0755498211005586

van Hul IJ , Schwagten V , Vrelust I . Association of aortic valve stenosis and recurrent gastrointestinal bleeding . Eur J Emerg Med 2012 ; 19 ( 2 ): 122 - 4 . doi: 10.1097/MEJ.0b013e32834991a0 https://dx.doi.org/10.1097/MEJ.0b013e32834991a0 . DOI: 10.1097/MEJ.0b013e32834991a0 http://doi.org/10.1097/MEJ.0b013e32834991a0 http://journals.lww.com/00063110-201204000-00013 http://journals.lww.com/00063110-201204000-00013

Abi-Akar R , El-Rassi I , Karam N , et al . Treatment of Heyde’s Syndrome by aortic valve replacement . Curr Cardiol Rev 2011 ; 7 ( 1 ): 47 - 9 . doi: 10.2174/157340311795677699 https://dx.doi.org/10.2174/157340311795677699 . DOI: 10.2174/157340311795677699 http://doi.org/10.2174/157340311795677699

D’Souza PM , Blostein MD . Diagnosis of Heyde’s syndrome by abnormal closure times despite normal von Willebrand’s activity . Blood Coagul Fibrinolysis 2011 ; 22 ( 7 ): 622 - 3 . doi: 10.1097/MBC.0b013e32834a04d3 https://dx.doi.org/10.1097/MBC.0b013e32834a04d3 . DOI: 10.1097/MBC.0b013e32834a04d3 http://doi.org/10.1097/MBC.0b013e32834a04d3 http://journals.lww.com/00001721-201110000-00014 http://journals.lww.com/00001721-201110000-00014

Takahashi N , Tanabe K , Yoshitomi H , et al . Successful endoscopic clipping for bleeding from colonic angiodysplasia in a case of Heyde syndrome . Med Sci Monit 2010 ; 16 ( 9 ):CS107-9.

Undas A , Windyga J , Bykowska K , et al . Heyde’s syndrome without a decrease in large von Willebrand factor multimers: a case of intestinal bleedings reversed by valve replacement in a patient with aortic stenosis . Thromb Haemost 2009 ; 101 ( 4 ): 773 - 4 . DOI: 10.1160/TH08-07-0422 http://doi.org/10.1160/TH08-07-0422 http://www.thieme-connect.de/DOI/DOI?10.1160/TH08-07-0422 http://www.thieme-connect.de/DOI/DOI?10.1160/TH08-07-0422

Morishima A , Marui A , Shimamoto T , et al . Successful aortic valve replacement for Heyde syndrome with confirmed hematologic recovery . Ann Thorac Surg 2007 ; 83 ( 1 ): 287 - 8 . doi: 10.1016/j.athoracsur.2006.05.082 https://dx.doi.org/10.1016/j.athoracsur.2006.05.082 . DOI: 10.1016/j.athoracsur.2006.05.082 http://doi.org/10.1016/j.athoracsur.2006.05.082

Singh P , Scoyni R , Pooran N , et al . Aortic valve replacement: a last resort for aortic stenosis-associated refractory GI bleeding . Gastrointest Endosc 2002 ; 56 ( 1 ): 139 - 41 . doi: 10.1067/mge.2002.125108 https://dx.doi.org/10.1067/mge.2002.125108 . DOI: 10.1067/mge.2002.125108 http://doi.org/10.1067/mge.2002.125108 https://linkinghub.elsevier.com/retrieve/pii/S0016510702000275 https://linkinghub.elsevier.com/retrieve/pii/S0016510702000275

Soran H , Lewis M , Whorwell PJ . Bleeding angiodysplasia: should we concentrate more on the aortic valve than on the bowel? . Int J Clin Pract 2002 ; 56 ( 2 ): 155 - 6 .

Warkentin TE , Moore JC , Morgan DG . Gastrointestinal angiodysplasia and aortic stenosis . N Engl J Med 2002 ; 347 ( 11 ): 858 - 9 . doi: 10.1056/NEJM200209123471122 https://dx.doi.org/10.1056/NEJM200209123471122 . DOI: 10.1056/NEJM200209123471122 http://doi.org/10.1056/NEJM200209123471122 http://www.nejm.org/doi/abs/10.1056/NEJM200209123471122 http://www.nejm.org/doi/abs/10.1056/NEJM200209123471122

Anderson RP , McGrath K , Street A . Reversal of aortic stenosis, bleeding gastrointestinal angiodysplasia, and von Willebrand syndrome by aortic valve replacement . Lancet 1996 ; 347 ( 9002 ): 689 - 90 . doi: 10.1016/s0140-6736(96)91240-4 https://dx.doi.org/10.1016/s0140-6736(96)91240-4 . DOI: 10.1016/s0140-6736(96)91240-4 http://doi.org/10.1016/s0140-6736(96)91240-4

Olearchyk AS . Heyde’s syndrome . J Thorac Cardiovasc Surg 1992 ; 103 ( 4 ): 823 - 4 . DOI: 10.1016/S0022-5223(19)34973-6 http://doi.org/10.1016/S0022-5223(19)34973-6 https://linkinghub.elsevier.com/retrieve/pii/S0022522319349736 https://linkinghub.elsevier.com/retrieve/pii/S0022522319349736

Apostolakis E , Doering C , Kantartzis M , et al . Calcific aortic-valve stenosis and angiodysplasia of the colon: Heyde’s syndrome—report of two cases . Thorac Cardiovasc Surg 1990 ; 38 ( 6 ): 374 - 6 . doi: 10.1055/s-2007-1014055 https://dx.doi.org/10.1055/s-2007-1014055 . DOI: 10.1055/s-2007-1014055 http://doi.org/10.1055/s-2007-1014055 http://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-1014055 http://www.thieme-connect.de/DOI/DOI?10.1055/s-2007-1014055

Casson AG , McKenzie NN . Heyde’s syndrome . Chest 1988 ; 94 ( 4 ): 891 - 2 . doi: 10.1378/chest.94.4.891 https://dx.doi.org/10.1378/chest.94.4.891 . DOI: 10.1378/chest.94.4.891 http://doi.org/10.1378/chest.94.4.891

Baciewicz FA Jr , Davis JT . Heyde’s syndrome: failure of a mechanical prosthesis and the possibility of a coagulation defect . Ann Thorac Surg 1987 ; 44 ( 5 ): 554 - 5 . doi: 10.1016/s0003-4975(10)62126-1 https://dx.doi.org/10.1016/s0003-4975(10)62126-1 . DOI: 10.1016/s0003-4975(10)62126-1 http://doi.org/10.1016/s0003-4975(10)62126-1

Cappell MS , Lebwohl O . Cessation of recurrent bleeding from gastrointestinal angiodysplasias after aortic valve replacement . Ann Intern Med 1986 ; 105 ( 1 ): 54 - 7 . doi: 10.7326/0003-4819-105-1-54 https://dx.doi.org/10.7326/0003-4819-105-1-54 . DOI: 10.7326/0003-4819-105-1-54 http://doi.org/10.7326/0003-4819-105-1-54

Scheffer SM , Leatherman LL . Resolution of Heyde’s syndrome of aortic stenosis and gastrointestinal bleeding after aortic valve replacement . Ann Thorac Surg 1986 ; 42 ( 4 ): 477 - 80 . doi: 10.1016/s0003-4975(10)60563-2 https://dx.doi.org/10.1016/s0003-4975(10)60563-2 . DOI: 10.1016/s0003-4975(10)60563-2 http://doi.org/10.1016/s0003-4975(10)60563-2

Marcus RH , Kinsley RH . Aortic stenosis and unexplained gastro-intestinal haemorrhage. Case reports . S Afr Med J 1982 ; 61 ( 15 ): 559 - 61 .

Danilewitz M , McKibbin J , Derman D . Cessation of gastrointestinal bleeding after valve replacement of aortic stenosis . Am Heart J 1981 ; 101 ( 5 ): 686 . doi: 10.1016/0002-8703(81)90245-3 https://dx.doi.org/10.1016/0002-8703(81)90245-3 . DOI: 10.1016/0002-8703(81)90245-3 http://doi.org/10.1016/0002-8703(81)90245-3

Love JW , Jahnke EJ , Zacharias D , et al . Calcific aortic stenosis and gastrointestinal bleeding . N Engl J Med 1980 ; 302 ( 17 ): 968 . doi: 10.1056/NEJM198004243021716 https://dx.doi.org/10.1056/NEJM198004243021716 . DOI: 10.1056/NEJM198004243021716 http://doi.org/10.1056/NEJM198004243021716 http://www.nejm.org/doi/abs/10.1056/NEJM198004243021716 http://www.nejm.org/doi/abs/10.1056/NEJM198004243021716

Pate GE , Chandavimol M , Naiman SC , et al . Heyde’s syndrome: a review . J Heart Valve Dis 2004 ; 13 ( 5 ): 701 - 12 .

Massyn MW , Khan SA . Heyde syndrome: a common diagnosis in older patients with severe aortic stenosis . Age Ageing 2009 ; 38 ( 3 ): 267 - 70 ; discussion 251. doi: 10.1093/ageing/afp019 https://dx.doi.org/10.1093/ageing/afp019 . DOI: 10.1093/ageing/afp019 http://doi.org/10.1093/ageing/afp019

Gelfand ML , Cohen T , Ackert JJ , et al . Gastrointestinal bleeding in aortic stenosis . Am J Gastroenterol 1979 ; 71 ( 1 ): 30 - 8 .

Ogano M , Iwasaki YK , Takano H , et al . Successful colectomy for the treatment of repetitive bleeding from colonic angiodysplasia in a patient with Heyde syndrome . Intern Med 2006 ; 45 ( 6 ): 355 - 8 . doi: 10.2169/internalmedicine.45.1526 https://dx.doi.org/10.2169/internalmedicine.45.1526 . DOI: 10.2169/internalmedicine.45.1526 http://doi.org/10.2169/internalmedicine.45.1526 http://www.jstage.jst.go.jp/article/internalmedicine/45/6/45_6_355/_article http://www.jstage.jst.go.jp/article/internalmedicine/45/6/45_6_355/_article

Warkentin TE , Moore JC , Morgan DG . Aortic stenosis and bleeding gastrointestinal angiodysplasia: is acquired von Willebrand’s disease the link? Lancet 1992 ; 340 ( 8810 ): 35 - 7 . doi: 10.1016/0140-6736(92)92434-h https://dx.doi.org/10.1016/0140-6736(92)92434-h . DOI: 10.1016/0140-6736(92)92434-h http://doi.org/10.1016/0140-6736(92)92434-h

Desai R , Parekh T , Singh S , et al . Alarming increasing trends in hospitalizations and mortality with Heyde’s Syndrome: a nationwide inpatient perspective (2007 to 2014) . Am J Cardiol 2019 ; 123 ( 7 ): 1149 - 55 . doi: 10.1016/j.amjcard.2018.12.043 https://dx.doi.org/10.1016/j.amjcard.2018.12.043 . DOI: 10.1016/j.amjcard.2018.12.043 http://doi.org/10.1016/j.amjcard.2018.12.043 https://linkinghub.elsevier.com/retrieve/pii/S0002914919300463 https://linkinghub.elsevier.com/retrieve/pii/S0002914919300463

Mondal S , Hollander KN , Ibekwe SO , et al . Heyde Syndrome―pathophysiology and perioperative implications . J Cardiothorac Vasc Anesth 2020 ; S1053-0770 ( 20 ) 31098 - 3 . doi: 10.1053/j.jvca.2020.10.003 https://dx.doi.org/10.1053/j.jvca.2020.10.003 . DOI: 10.1053/j.jvca.2020.10.003 http://doi.org/10.1053/j.jvca.2020.10.003

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