短疗程睑缘清洁联合抗生素滴眼液的使用对白内障术前眼表菌群抑制作用的临床研究

陈晓勇; 蔡宏媛; 刘忆南; 洪晶

doi:10.24920/003901

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短疗程睑缘清洁联合抗生素滴眼液的使用对白内障术前眼表菌群抑制作用的临床研究

中国医学科学杂志（英文版） 2022年37卷第2期页码：118-126

Original Article | Updated：2024-04-10

- 短疗程睑缘清洁联合抗生素滴眼液的使用对白内障术前眼表菌群抑制作用的临床研究
- Affiliations：
  
  Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China
- Author bio：
  
  * Tel: 86-13910573646, Fax: 86-10-82089951, E-mail: hongjing196401@163.com
- Funds：
- DOI：10.24920/003901
  中图分类号：
- 收稿日期：2021-03-21，
  
  录用日期：2022-2-16，
  
  网络出版日期：2022-04-18，
  
  纸质出版日期：2022-06-30
- Accepted：
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陈晓勇, 蔡宏媛, 刘忆南, 等. 短疗程睑缘清洁联合抗生素滴眼液的使用对白内障术前眼表菌群抑制作用的临床研究[J]. 中国医学科学杂志（英文版）, 2022,37(2):118-126.

Xiaoyong Chen, Hongyuan Cai, Yinan Liu, et al. Inhibitory Effect of Short-Term Palpebral Margin Cleaning with Antibiotic Eye Drops on Ocular Surface Flora before Cataract Extraction: A New Preoperative Antibacterial Method[J]. Chinese medical sciences journal, 2022, 37(2): 118-126.
陈晓勇, 蔡宏媛, 刘忆南, 等. 短疗程睑缘清洁联合抗生素滴眼液的使用对白内障术前眼表菌群抑制作用的临床研究[J]. 中国医学科学杂志（英文版）, 2022,37(2):118-126. DOI： 10.24920/003901.

Xiaoyong Chen, Hongyuan Cai, Yinan Liu, et al. Inhibitory Effect of Short-Term Palpebral Margin Cleaning with Antibiotic Eye Drops on Ocular Surface Flora before Cataract Extraction: A New Preoperative Antibacterial Method[J]. Chinese medical sciences journal, 2022, 37(2): 118-126. DOI： 10.24920/003901.

摘要

目的

探讨睑缘清洁与抗生素滴眼液的联合使用对白内障患者术前睑缘和结膜囊细菌抑制作用的临床效果。

方法

收集于北京大学第三医院拟行超声乳化白内障吸除联合人工晶体植入术的年龄相关性白内障患者61例（97只眼）。试验组术前3 d滴用左氧氟沙星眼液并联合使用睑缘清洁棉片;对照组术前3 d滴用左氧氟沙星滴眼液。试验组和对照组均在采取抗菌措施前、采取抗菌措施3 d后2个时间点对术眼睑缘、结膜囊分别取材进行细菌培养及鉴定。

结果

试验组在使用抗菌措施前睑缘和结膜囊细菌培养阳性率分别为100%（50/50）和40%（20/50）;采用抗菌措施3d后分别为10%（5/50）和0%（0/50）。对照组在使用抗菌措施前睑缘和结膜囊细菌培养阳性率分别为97.9%（46/47）和29.8%（14/47）;采用抗菌措施3d后分别为40.4%（19/47）和10.6%（5/47）。采用抗菌措施前试验组和对照组睑缘和结膜囊细菌培养阳性率差异无统计学意义（P值分别为0.485和0.395）

采用抗菌措施后差异有统计学意义（P值分别为0.001和0.024）。

结论

白内障摘除术前

抗生素滴眼液联合睑缘清洁棉片对睑缘和结膜囊有良好的抑菌效果。此外

这种联合清洁棉片的术前抗菌方法可以在保留良好抗菌效果的同时有效减少术前抗生素药物的使用。

Abstract

Objective

To explore the clinical significance of the combined application of palpebral margin cleaning and antibiotic eye drops in inhibiting bacterial growth in the palpebral margin and conjunctival sacs before cataract extraction.

Methods

In this study

61 patients (97 eyes) with age-related cataract who underwent phacoemulsification and intraocular lens implantation were selected

and randomly grouped. In the experimental group

the combined application of palpebral margin cleaning with cotton pads and levofloxacin eye drops was given for three days before the surgery. In the control group

levofloxacin eye drops alone were applied for three consecutive days. Bacteria samples from the conjunctival sac and eyelid margins were cultivated and identified before and three days after taking antimicrobial measures

respectively.

Results

In the experimental group

the positive rates of the two bacteria samples were 100% (50/50) and 40% (20/50) before and 10% (5/50) and 0% (0/50) after the treatment. In the control group

the positive rates of the two bacteria samples were 97.9% (46/47) and 29.8% (14/47) before and 40.4% (19/47) and 10.6% (5/47) after the treatment. The positive rates between the two groups were not significantly different before taking antimicrobial measures (

= 0.485 and 0.395)

while they were significantly different after taking antimicrobial measures (

= 0.001 and 0.024).

Conclusion

Combined application of eyelid and palpebral margin cleaning with cotton pads and antibiotic eye drops before cataract extraction imparted excellent antibacterial effects.

关键词

Keywords

references

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