去甲乌药碱：一种潜在的冠心病诊断心肌负荷药物

张娜娜; 李子健; 朱海波

doi:10.24920/003936

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去甲乌药碱：一种潜在的冠心病诊断心肌负荷药物

中国医学科学杂志（英文版） 2022年37卷第3期页码：275-281

Review | Updated：2024-04-10

- 去甲乌药碱：一种潜在的冠心病诊断心肌负荷药物
- Affiliations：
  
  1. 1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100050, China
  2. 2Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100050, China
  3. 3State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
- Author bio：
  
  *李子健 lizijian@bjmu.edu.cn;
  朱海波 zhuhaibo@imm.ac.cn
- Funds：
  
  中国医学科学院医学与健康科技创新工程(2021-1-I2M-028)
- DOI：10.24920/003936
  中图分类号：
- 收稿日期：2021-05-16，
  
  录用日期：2022-1-23，
  
  网络出版日期：2022-06-26，
  
  纸质出版日期：2022-09-30
- Accepted：
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张娜娜, 李子健, 朱海波. 去甲乌药碱：一种潜在的冠心病诊断心肌负荷药物[J]. 中国医学科学杂志（英文版）, 2022,37(3):275-281.

Nana Zhang, Zijian Li, Haibo Zhu. Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease[J]. Chinese medical sciences journal, 2022, 37(3): 275-281.
张娜娜, 李子健, 朱海波. 去甲乌药碱：一种潜在的冠心病诊断心肌负荷药物[J]. 中国医学科学杂志（英文版）, 2022,37(3):275-281. DOI： 10.24920/003936.

Nana Zhang, Zijian Li, Haibo Zhu. Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease[J]. Chinese medical sciences journal, 2022, 37(3): 275-281. DOI： 10.24920/003936.

摘要

心肌灌注显像在冠心病的诊断、预后和管理中具有重要价值。当前

血管扩张剂和肾上腺素剂是最常见的心肌负荷药物。然而

这些药物在部分病人中的应用有限制

并且有多种副反应。因而

有必要开发可以在更多病人中应用的心肌负荷药物。去甲乌药碱是一种β受体激动剂

被批准作为心肌负荷药物应用于心肌缺血的诊断。因其正性肌力作用

去甲乌药碱有望成为用于冠心病诊断的心肌灌注显像负荷药物。本综述总结了去甲乌药碱在心肌灌注显像中的应用

包括其作用机制、给药方式、有效性及安全性。

Abstract

Myocardial perfusion imaging (MPI) is valuable for the diagnosis

prognosis

and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However

these agents have contraindications and may cause adverse effects in some patients. Thus

other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI

including its mechanism of action

stress protocol

efficacy

and safety.

关键词

Keywords

references

Tsao CW , Aday AW , Almarzooq ZI , et al. Heart disease and stroke statistics-2022 update: A report from the American Heart Association . Circulation 2022 ; 145 ( 8 ): e153 - e639 . doi: 10.1161/CIR https://dx.doi.org/10.1161/CIR .0000000000001052. DOI: 10.1161/CIR http://doi.org/10.1161/CIR

Li DL , Kronenberg MW . Myocardial perfusion and viability imaging in coronary artery disease: clinical value in diagnosis, prognosis, and therapeutic guidance . Am J Med 2021 ; 134 ( 8 ): 968 - 75 . doi: 10.1016/j.amjmed.2021.03.011 https://dx.doi.org/10.1016/j.amjmed.2021.03.011 . DOI: 10.1016/j.amjmed.2021.03.011 http://doi.org/10.1016/j.amjmed.2021.03.011 https://linkinghub.elsevier.com/retrieve/pii/S0002934321002242 https://linkinghub.elsevier.com/retrieve/pii/S0002934321002242

Eldirani M , Chehab O , Hassan H , et al. Variations in the referral patterns to pharmacologic and exercise myocardial perfusion imaging . J Nucl Cardiol 2018 ; 25 ( 5 ): 1708 - 14 . doi: 10.1007/s12350-017-1071-0 https://dx.doi.org/10.1007/s12350-017-1071-0 . DOI: 10.1007/s12350-017-1071-0 http://doi.org/10.1007/s12350-017-1071-0

Nguyen TH , Horowitz JD , Unger SA , et al. pharmacologic stress myocardial perfusion imaging: differential implications in multi-vessel ischemia . Am J Cardiovasc Dis 2012 ; 2 ( 1 ): 34 - 42 . doi: 10.3917/rmm.021.0123 https://dx.doi.org/10.3917/rmm.021.0123 . DOI: 10.3917/rmm.021.0123 http://doi.org/10.3917/rmm.021.0123

Argulian E , Po JR , Uretsky S , et al. Comparison of the current reasons for undergoing pharmacologic stress during echocardiographic and radionuclide stress testing . J Nucl Cardiol 2017 ; 24 ( 2 ): 546 - 54 . doi: 10.1007/s12350-016-0398-2 https://dx.doi.org/10.1007/s12350-016-0398-2 . DOI: 10.1007/s12350-016-0398-2 http://doi.org/10.1007/s12350-016-0398-2

Haberkorn SM , Haberkorn SI , Bönner F , et al. Vasodilator myocardial perfusion cardiac magnetic resonance imaging is superior to dobutamine stress echocardiography in the detection of relevant coronary artery stenosis: a systematic review and meta-analysis on their diagnostic accuracy . Front Cardiovasc Med 2021 ; 8 : 630846 . doi: 10.3389/fcvm.2021.630846 https://dx.doi.org/10.3389/fcvm.2021.630846 . DOI: 10.3389/fcvm.2021.630846 http://doi.org/10.3389/fcvm.2021.630846 https://www.frontiersin.org/articles/10.3389/fcvm.2021.630846/full https://www.frontiersin.org/articles/10.3389/fcvm.2021.630846/full

Van Tosh A and Nichols KJ . Pharmacologic stress myocardial perfusion imaging in patients with pulmonary hypertension: What do we know, and what remains to be learned? J Nucl Cardiol 2018 ; 25 ( 3 ): 828 - 32 . doi: 10.1007/s12350-016-0771-1 https://dx.doi.org/10.1007/s12350-016-0771-1 . DOI: 10.1007/s12350-016-0771-1 http://doi.org/10.1007/s12350-016-0771-1

Tamarappoo BK , Lee FL , Cerqueira M , et al. Independent prognostic value of left ventricular contractile reserve and chronotropic response in patients with reduced left ventricular ejection fraction undergoing vasodilator stress myocardial perfusion imaging with Rb-82 positron emission tomography . Eur Heart J Cardiovasc Imaging 2018 ; 19 ( 4 ): 442 - 9 . doi: 10.1093/ehjci/jex157 https://dx.doi.org/10.1093/ehjci/jex157 . DOI: 10.1093/ehjci/jex157 http://doi.org/10.1093/ehjci/jex157

Geleijnse ML , Elhendy A , Fioretti PM , et al. Dobutamine stress myocardial perfusion imaging . J Am Coll Cardiol 2000 ; 36 ( 7 ): 2017 - 27 . doi: 10.1016/s0735-1097(00)01012-3 https://dx.doi.org/10.1016/s0735-1097(00)01012-3 . DOI: 10.1016/s0735-1097(00)01012-3 http://doi.org/10.1016/s0735-1097(00)01012-3

Pagnanelli RA , Camposano HL . Pharmacologic stress testing with myocardial perfusion Imaging . J Nucl Med Technol 2017 ; 45 ( 4 ): 249 - 52 . doi: 10.2967/jnmt.117.199208 https://dx.doi.org/10.2967/jnmt.117.199208 . DOI: 10.2967/jnmt.117.199208 http://doi.org/10.2967/jnmt.117.199208

Johnson SG , Peters S . Advances in pharmacologic stress agents: focus on regadenoson . J Nucl Med Technol 2010 ; 38 ( 3 ): 163 - 71 . doi: 10.2967/jnmt.109.065581 https://dx.doi.org/10.2967/jnmt.109.065581 . DOI: 10.2967/jnmt.109.065581 http://doi.org/10.2967/jnmt.109.065581

Kosuge T , Yokota M . Letter: Studies on cardiac principle of aconite root . Chem Pharm Bull (Tokyo) 1976 ; 24 ( 1 ): 176 - 8 . doi: 10.1248/cpb.24.176 https://dx.doi.org/10.1248/cpb.24.176 . DOI: 10.1248/cpb.24.176 http://doi.org/10.1248/cpb.24.176 http://www.jstage.jst.go.jp/article/cpb1958/24/1/24_1_176/_article http://www.jstage.jst.go.jp/article/cpb1958/24/1/24_1_176/_article

Zhang N , Lian Z , Peng X , et al . Applications of Higenamine in pharmacology and medicine . J Ethnopharmacol 2017 ; 196 : 242 - 52 . doi: 10.1016/j.jep.2016.12.033 https://dx.doi.org/10.1016/j.jep.2016.12.033 . DOI: S0378-8741(16)31083-2 http://doi.org/S0378-8741(16)31083-2

Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Meidcal College . Over six decades of inheritance, development, and innovation at the Institute of Materia Medica of the Chinese Academy of Medical Sciences - Past, present, and future for a big blueprint for a Healthy China . Chinese. Available from: https://www.imm.ac.cn//lbtp/417a4063fd154c7b890ce312417f809e.htm https://www.imm.ac.cn//lbtp/417a4063fd154c7b890ce312417f809e.htm https://www.imm.ac.cn//lbtp/417a4063fd154c7b890ce312417f809e.htm. Accessed: May 5, 2022 .

Wen J , Li M , Zhang W , et al. Role of higenamine in heart diseases: a mini-review . Front Pharmacol 2021 ; 12 : 798495 . doi: 10.3389/fphar.2021.798495 https://dx.doi.org/10.3389/fphar.2021.798495 . DOI: 10.3389/fphar.2021.798495 http://doi.org/10.3389/fphar.2021.798495 https://www.frontiersin.org/articles/10.3389/fphar.2021.798495/full https://www.frontiersin.org/articles/10.3389/fphar.2021.798495/full

Kosuge T , Yokota M , Nagasawa M . [Studies on cardiac principle in Aconite roots. I. Isolation and structural determination of higenamine] . Yakugaku Zasshi 1978 ; 98 ( 10 ): 1370 - 5 . doi: 10.1248/yakushi1947.98.10_1370 https://dx.doi.org/10.1248/yakushi1947.98.10_1370 . DOI: 10.1248/yakushi1947.98.10_1370 http://doi.org/10.1248/yakushi1947.98.10_1370

Chen Y , Guo B , Zhang H , et al. Higenamine, a dual agonist for beta 1- and beta 2-adrenergic receptors identified by screening a traditional Chinese medicine library . Planta Med 2019 ; 85 ( 9-10 ): 738 - 44 . doi: 10.1055/a-0942-4502 https://dx.doi.org/10.1055/a-0942-4502 . DOI: 10.1055/a-0942-4502 http://doi.org/10.1055/a-0942-4502 http://www.thieme-connect.de/DOI/DOI?10.1055/a-0942-4502 http://www.thieme-connect.de/DOI/DOI?10.1055/a-0942-4502

Yu F , Kong L , Wang S . Influence of racemic higenamine on the sinus node . Exp Ther Med 2013 ; 5 ( 2 ): 591 - 5 . doi: 10.3892/etm.2012.813 https://dx.doi.org/10.3892/etm.2012.813 . DOI: 10.3892/etm.2012.813 http://doi.org/10.3892/etm.2012.813

Zhang N , Zhu H , Li Z , et al. A novel beta2-AR agonist, Higenamine, induces beta-arrestin-biased signaling . Sci China Life Sci 2021 ; 65 ( 7 ): 1357 - 68 . doi: 10.1007/s11427-021-2008-1 https://dx.doi.org/10.1007/s11427-021-2008-1 . DOI: 10.1007/s11427-021-2008-1 http://doi.org/10.1007/s11427-021-2008-1

Wang W , Bian J , Li Z . Internalized activation of membrane receptors: from phenomenon to theory . Trends Cell Biol 2021 ; 31 ( 6 ): 428 - 31 . doi: 10.1016/j.tcb.2021.03.008 https://dx.doi.org/10.1016/j.tcb.2021.03.008 . DOI: 10.1016/j.tcb.2021.03.008 http://doi.org/10.1016/j.tcb.2021.03.008

Zhang N , Qu K , Wang M , et al. Identification of higenamine as a novel alpha 1 -adrenergic receptor antagonist . Phytother Res 2019 ; 33 ( 3 ): 708 - 17 . doi: 10.1002/ptr.6261 https://dx.doi.org/10.1002/ptr.6261 . DOI: 10.1002/ptr.6261 http://doi.org/10.1002/ptr.6261

Chen ZZ , Liu L , Zhou TJ , et al. Effect of Asarum heterotropoides on the left ventricular function of dogs . Yao Xue Xue Bao 1981 ; 16 ( 10 ): 721 - 7 . Chinese.

Liu XJ , Tao Z , Shi RF , et al. Experimental study of a new pharmacological stress test agent-igenamine . Chinese Circ J 1997 ; 12 ( 4 ): 304 - 7 .

Zhang Z , Liu XJ , Tao ZH , et al. Effects of higeramine on hemodynamics and its tolerability and safety, an experimental study . Natl Med J China 2002 ; 82 ( 5 ): 352 - 5 .

Zheng YL , Shen R , Yang MF , et al. Experimental study of pharmaceutic stress myocardial perfusion imaging with higenamine . Chin J Cardiol 2005 ; 33 ( 5 ): 473 - 5 . Chinese.

Huang NH , Zhou YP , Liu WH , et al. Comparison of cardiovascular effects of aconite root and higenamine in dogs . Acta Pharmacol Sin 1980 ; 1 ( 1 ): 34 - 9 . Chinese.

Lo CF , Chen CM . Acute toxicity of higenamine in mice . Planta Med 1997 ; 63 ( 1 ): 95 - 6 . doi: 10.1055/s-2006-957619 https://dx.doi.org/10.1055/s-2006-957619 . DOI: 10.1055/s-2006-957619 http://doi.org/10.1055/s-2006-957619

Mann A , Williams J . Considerations for stress testing performed in conjunction with myocardial perfusion imaging . J Nucl Med Technol 2020 ; 48 ( 2 ): 114 - 21 . doi: 10.2967/jnmt.120.245308 https://dx.doi.org/10.2967/jnmt.120.245308 . DOI: 10.2967/jnmt.120.245308 http://doi.org/10.2967/jnmt.120.245308

Feng S , Jiang J , Hu P , et al. A phase I study on pharmacokinetics and pharmacodynamics of higenamine in healthy Chinese subjects . Acta Pharmacol Sin 2012 ; 33 ( 11 ): 1353 - 8 . doi: 10.1038/aps.2012.114 https://dx.doi.org/10.1038/aps.2012.114 . DOI: 10.1038/aps.2012.114 http://doi.org/10.1038/aps.2012.114

Du YR , Li F , Xu RY , et al. Tolerability of higenamine hydrochloride in healthy volunteers . Chin J Clin Pharm 2007 ; 23 ( 4 ): 258 - 60 . Chinese. doi: 10.13699/j.cnki.1001-6821.2007.04.012 https://dx.doi.org/10.13699/j.cnki.1001-6821.2007.04.012 . DOI: 10.13699/j.cnki.1001-6821.2007.04.012 http://doi.org/10.13699/j.cnki.1001-6821.2007.04.012

Zhou W , Wang F , Zhang LL , et al. Myocardial perfusion imaging with higenamine hydrochloride stress studies in diagnosis of coronary artery disease . Chin J Necl Med Mol Imaging 2012 ; 32 ( 6 ): 408 - 12 . Chinese. doi: 10.3760/cma.j.issn.2095-2848.2012.06.002 https://dx.doi.org/10.3760/cma.j.issn.2095-2848.2012.06.002 . DOI: 10.3760/cma.j.issn.2095-2848.2012.06.002 http://doi.org/10.3760/cma.j.issn.2095-2848.2012.06.002

Tian R , Wang Q , Mi HZ , et al. Efficacy and safety of higena-mine hydrochlrodide injection used in pharmacological stress myocardial perfusion imaging . Chin J Clin Pharm 2012 ; 28 ( 2 ): 88 - 90 .

Cao Y , Wang ZZ , Wang F , et al. Dectection of coronary heart disease with 99Tcm-MIBI myocardial perfusion imaging stressed by intravenous infusion of higenamine hydrochloride . Chin J Nucl Med Mol Imaging 2012 ; 32 ( 3 ): 203 - 5 . Chinese. doi: 10.3760/cma.j.issn.2095-2848.2012.03.010 https://dx.doi.org/10.3760/cma.j.issn.2095-2848.2012.03.010 . DOI: 10.3760/cma.j.issn.2095-2848.2012.03.010 http://doi.org/10.3760/cma.j.issn.2095-2848.2012.03.010

Du YR , Wang Q , Li DF , et al. Efficacy and safety of a novel pharmacological stress test agent-higenamine in radionuclide myocardial perfusion imaging: phase II clinical trial . Chin J Nucl Med Mol Imaging 2014 ; 34 ( 1 ): 34 - 8 . Chinese. doi: 10.3760/cma.j.issn.2095-2848.2014.01.011 https://dx.doi.org/10.3760/cma.j.issn.2095-2848.2014.01.011 . DOI: 10.3760/cma.j.issn.2095-2848.2014.01.011 http://doi.org/10.3760/cma.j.issn.2095-2848.2014.01.011

Mi HZ , Wang Q , Tian R , et al. The clinical availability of hydrochloric acid higenamine as a stress medicine in radionuclide myocardial perfusion imaging to diagnose coronary artery disease . J Cardiovascular Pulmonary Dis 2015 ; 34 ( 6 ): 486 - 8 . Chinese. doi: 10.3969/j.issn.1007-5062.2015.06.014 https://dx.doi.org/10.3969/j.issn.1007-5062.2015.06.014 . DOI: 10.3969/j.issn.1007-5062.2015.06.014 http://doi.org/10.3969/j.issn.1007-5062.2015.06.014

Sun Y , Hou P . Hydrochloric acid higenamine load 99Tcm-MIBI myocardial perfusion imaging in the diagnosis of coronary artery disease . China Health Standard Management 2015 ; 34 ( 6 ): 486 - 8 . Chinese. doi: 10.3969/j.issn1674-9316.201502.057.Chinese https://dx.doi.org/10.3969/j.issn1674-9316.201502.057.Chinese . DOI: 10.3969/j.issn1674-9316.201502.057.Chinese http://doi.org/10.3969/j.issn1674-9316.201502.057.Chinese

Bai H , Fang LG , Xu RY , et al. Efficacy and safety of higenamine hydrochloride stress echocardiography for diagnosis of coronary artery disease . Chin J Ultrasonogr 2018 ; 27 ( 1 ): 104 - 7 . Chinese. doi: 10.3760/cma.j.issn.1004-4477.2018.01.003 https://dx.doi.org/10.3760/cma.j.issn.1004-4477.2018.01.003 . DOI: 10.3760/cma.j.issn.1004-4477.2018.01.003 http://doi.org/10.3760/cma.j.issn.1004-4477.2018.01.003

JV Monmeneu Menadas , García Gonzalez MP , MP Lopez-Lereu , et al. Safety and tolerability of regadenoson in comparison with adenosine stress cardiovascular magnetic resonance: Data from a multicentre prospective registry . Int J Cardiovasc Imaging 2022 ; 38 ( 1 ): 195 - 209 . doi: 10.1007/s10554-021-02363-4 https://dx.doi.org/10.1007/s10554-021-02363-4 . DOI: 10.1007/s10554-021-02363-4 http://doi.org/10.1007/s10554-021-02363-4 https://doi.org/10.1007/s10554-021-02363-4 https://doi.org/10.1007/s10554-021-02363-4

Rai M , Ahlberg AW , Marwell J , et al. Safety of vasodilator stress myocardial perfusion imaging in patients with elevated cardiac biomarkers . J Nucl Cardiol 2017 ; 24 ( 2 ): 724 - 34 . doi: 10.1007/s12350-016-0448-9 https://dx.doi.org/10.1007/s12350-016-0448-9 . DOI: 10.1007/s12350-016-0448-9 http://doi.org/10.1007/s12350-016-0448-9

Heringlake M , Alvarez J , Bettex D , et al. An update on levosimendan in acute cardiac care: applications and recommendations for optimal efficacy and safety . Expert Rev Cardiovasc Ther 2021 ; 19 ( 4 ): 325 - 35 . doi: 10.1080/14779072.2021.1905520 https://dx.doi.org/10.1080/14779072.2021.1905520 . DOI: 10.1080/14779072.2021.1905520 http://doi.org/10.1080/14779072.2021.1905520 https://www.tandfonline.com/doi/full/10.1080/14779072.2021.1905520 https://www.tandfonline.com/doi/full/10.1080/14779072.2021.1905520

Xing G , Yi C , Dou P , et al. Recent progress in the development of beta2 adrenergic receptor agonists: a patent review (2015-2020) . Expert Opin Ther Pat 2021 ; 31 ( 3 ): 239 - 46 . doi: 10.1080/13543776.2021.1865312 https://dx.doi.org/10.1080/13543776.2021.1865312 . DOI: 10.1080/13543776.2021.1865312 http://doi.org/10.1080/13543776.2021.1865312 https://www.tandfonline.com/doi/full/10.1080/13543776.2021.1865312 https://www.tandfonline.com/doi/full/10.1080/13543776.2021.1865312

Huang YN , Shi JS , Lu WQ , et al. The effect of higenamine on relieving asthma . Yao Xue Tong Bao 1985 ; 20 ( 8 ): 462 - 4 . (Chinese)

Tsukiyama M , Ueki T , Yasuda Y , et al. Beta2-adrenoceptor-mediated tracheal relaxation induced by higenamine from Nandina domestic . Planta Medica 2009 ; 75 ( 13 ): 1393 - 9 . doi: 10.1055/s-0029-1185743 https://dx.doi.org/10.1055/s-0029-1185743 . DOI: 10.1055/s-0029-1185743 http://doi.org/10.1055/s-0029-1185743

Bai G , Yang Y , Shi Q , et al. Identification of higenamine in Radix Aconiti Lateralis Preparata as a beta2-adrenergic receptor agonist1 . Acta Pharmacol Sin 2008 ; 29 ( 10 ): 1187 - 94 . doi: 10.1111/j.1745-7254.2008.00859.x https://dx.doi.org/10.1111/j.1745-7254.2008.00859.x . DOI: 10.1111/j.1745-7254.2008.00859.x http://doi.org/10.1111/j.1745-7254.2008.00859.x

Cho SG , Jabin Z , Bom HH . Safer stress tests for myocardial perfusion imaging . J Nucl Cardiol 2019 ; 26 ( 2 ): 629 - 32 . doi: 10.1007/s12350-017-1083-9 https://dx.doi.org/10.1007/s12350-017-1083-9 . DOI: 10.1007/s12350-017-1083-9 http://doi.org/10.1007/s12350-017-1083-9 https://doi.org/10.1007/s12350-017-1083-9 https://doi.org/10.1007/s12350-017-1083-9

Jiang WQ , Tao SQ , Li JM , et al. Clinical study of the effect of higenamine on ejection fraction and bradyrthmia . Chin J Integr Tradi West Med 1981 ; 1 ( 1 ): 6 - 8 . Chinese.

Chen FH , Jiang WP , Zeng GY . Clinical electrophysiological studies of higenamine in sick sinus syndrome . Chin J Integr Traditi West Med 1984 ; 4 ( 1 ): 30 - 31 . Chinese.

Fang XY , Jiang WP , Chen FH , et al. Preliminary report of the effect of Fu Zi Yi Hao on sinoatrial node and atrioventricular node in aging . J Geriatircs 1982 . 11 ( 1 ): 39 - 41 .

Guo SK , Chen KJ , Qian ZZ , et al. To observe the clinical efficacy of hignamine combined with Shengmai in the treatment of bradyarrhythmia . Beijing Medcine 1981 ; 3 ( 2 ): 46 - 7 . Chinese.

Wang BK , Chen LY , Shang M , et al. Effects of dl-demethylcoclaurine on electrophysiological properties of porcine myocardial cells . Zhongguo Yao Li Xue Bao 1982 ; 3 ( 2 ): 112 - 7 . Chinese.

Gao TL , Zhuang H . The Effect of Fuzi I Hao On the Bradyarrhythmia in the mice . J Tradit Chin Med 1980 ; 10 ( 2 ): 71 .

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