硒蛋白脱碘酶的生物学功能及其在骨性关节炎患者中的表达

任晓梅; 张立; 辛宝; 刘启玲; 钱文文; 张荣强

doi:10.24920/003991

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硒蛋白脱碘酶的生物学功能及其在骨性关节炎患者中的表达

中国医学科学杂志（英文版） 2022年37卷第2期页码：142-150

Original Article | Updated：2024-04-10

- 硒蛋白脱碘酶的生物学功能及其在骨性关节炎患者中的表达
- Affiliations：
  
  1. 1Department of Nutrition and Food Hygiene, School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
  2. 2Department of Clinical Nutrition, The Affiliated Yantai Yuhuangding Hospital of Qingdao University Medical College, Yantai, Shandong 264000, China
  3. 3Department of Epidemiology and Medical Statistics, School of Public Health, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, China
- Author bio：
  
  * E-mail: zhangrqxianyang@163.com
- Funds：
- DOI：10.24920/003991
  中图分类号：
- 收稿日期：2021-09-06，
  
  录用日期：2022-4-8，
  
  网络出版日期：2022-05-30，
  
  纸质出版日期：2022-06-30
- Accepted：
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任晓梅, 张立, 辛宝, 等. 硒蛋白脱碘酶的生物学功能及其在骨性关节炎患者中的表达[J]. 中国医学科学杂志（英文版）, 2022,37(2):142-150.

Xiaomei Ren, Li Zhang, Bao Xin, et al. Biological Functions of Selenoprotein Iodothyronine Deiodinase and its Expression in Osteoarthritis[J]. Chinese medical sciences journal, 2022, 37(2): 142-150.
任晓梅, 张立, 辛宝, 等. 硒蛋白脱碘酶的生物学功能及其在骨性关节炎患者中的表达[J]. 中国医学科学杂志（英文版）, 2022,37(2):142-150. DOI： 10.24920/003991.

Xiaomei Ren, Li Zhang, Bao Xin, et al. Biological Functions of Selenoprotein Iodothyronine Deiodinase and its Expression in Osteoarthritis[J]. Chinese medical sciences journal, 2022, 37(2): 142-150. DOI： 10.24920/003991.

摘要

目的

骨关节炎（osteoarthritis

OA）是一种常见的关节疾病

老年人尤其高发。碘甲状腺原氨酸脱碘酶（iodothyronine deiodinases

DIOs）作为一种重要的硒蛋白

在骨和关节疾病中发挥着关键作用。本研究旨在利用生物信息学方法探讨DIOs在OA发病机制中的作用。

方法

通过对NCBI的GEO数据库中与OA相关的芯片数据进行数据挖掘

利用GenCLip 3.0

DAVID

STRING

Cytoscape和Network Analyst等工具分析DIOs的生物学功能

并用Review Manager5.3对数据进行Meta分析

研究DIOs在正常人和骨性关节炎患者中的表达。

结果

聚类分析显示：DIOs的功能与甲状腺激素受体和碘甲状腺原氨酸有关。GO分析显示：DIOs主要参与乙醇代谢和含酚化合物代谢等生物过程

还与外源生物的细胞色素P450代谢和甲状腺激素信号传导有关。SULT1A1是PPI网络的核心节点。miRNAs和甲状腺激素与DIO1和DIO2存在交互作用。Meta分析显示：DIO3的表达在OA患者中显著上调（

0.05）。

结论

DIOs的主要生物学功能与甲状腺激素的调节密切相关

而DIO3的上调表达可能在OA的发生中发挥关键作用。

Abstract

Objective

Iodothyronine deiodinases (DIOs) are important selenoproteins that play a key role in the bone and joint diseases. Osteoarthritis (OA) is the most prevalent joint disease especially in elders. This bioinformatic analysis was performed to explore the role of DIOs in OA pathogenesis.

Methods

The biological functions of selenoprotein DIOs were analyzed by bioinformatic techniques

including GenCLip 3.0

Database for Annotation

Visualization and Integrated Discovery (DAVID)

STRING

Cytoscape

and Network Analyst. The expression of DIOs in the healthy individuals and OA patients was determined by mining OA-related microarray data in the gene expression omnibus (GEO) database of National Center for Biotechnology Information and performing a Meta-analysis of the data with Review Manager 5.3.

Results

Cluster analysis revealed that the function of the DIOs was associated with thyroid hormone receptor and iodothyronine; GO analysis showed that DIOs were mainly involved in biological processes

such as ethanol metabolism and phenol-containing compound metabolism and primarily involved in the cytochrome P450 metabolism of exogenous organisms and thyroid hormone signaling; SULT1A1 was the core node of the PPI network; miRNAs and thyroid hormones had some iterations with

DIO1

and

DIO2

; Meta-analysis showed that

DIO3

expression was significantly up-regulated in OA patients (

SMD

= 0.31

95%

: 0.03

0.59

= 0.03).

Conclusions

The main biological functions of DIOs were closely associated with the regulation of thyroid hormone. And the up-regulated expression of

DIO3

may have crucial impact on the occurrence of OA.

关键词

Keywords

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