ANCA相关血管炎继发肾淀粉样变性：1例病例报告

何鑫; 宁建平; 许辉; 肖宫; 阳惠湘; 王维圆; 吴晓英; 尹红玲; 李晓照

doi:10.24920/003999

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ANCA相关血管炎继发肾淀粉样变性：1例病例报告

中国医学科学杂志（英文版） 2022年37卷第4期页码：359-362

Case Report | Updated：2024-04-10

- ANCA相关血管炎继发肾淀粉样变性：1例病例报告
- Affiliations：
  
  1. 1Department of Gastroenterology, Xiangya Hospital, Central South University, Changsha 410008, China
  2. 2Department of Nephrology, Xiangya Hospital, Central South University, Changsha 410008, China
  3. 3Department of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China
- Author bio：
  
  * E-mail: Hongling Yin: Yhl99@yahoo.com.cn;
  Xiaozhao Li: Tel: 86-731-89753773, E-mail: lixiaozhao@csu.edu.cn
- Funds：
- DOI：10.24920/003999
  中图分类号：
- 收稿日期：2021-09-13，
  
  录用日期：2022-4-1，
  
  网络出版日期：2022-06-28，
  
  纸质出版日期：2022-12-31
- Accepted：
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何鑫, 宁建平, 许辉, 等. ANCA相关血管炎继发肾淀粉样变性：1例病例报告[J]. 中国医学科学杂志（英文版）, 2022,37(4):359-362.

Xin He, Jianping Ning, Hui Xu, et al. Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report[J]. Chinese medical sciences journal, 2022, 37(4): 359-362.
何鑫, 宁建平, 许辉, 等. ANCA相关血管炎继发肾淀粉样变性：1例病例报告[J]. 中国医学科学杂志（英文版）, 2022,37(4):359-362. DOI： 10.24920/003999.

Xin He, Jianping Ning, Hui Xu, et al. Renal Amyloidosis Secondary to ANCA-Associated Vasculitis: A Case Report[J]. Chinese medical sciences journal, 2022, 37(4): 359-362. DOI： 10.24920/003999.

摘要

临床上继发于抗中性粒细胞胞浆抗体（anti-neutrophil cytoplasmic antibody，ANCA）相关血管炎的淀粉样蛋白A（amyloid A，AA）型淀粉样变性病例十分罕见。我们收治了1例77岁的ANCA相关血管炎女性患者。经活检取肾组织标本，Masson三色染色提示寡免疫复合物型新月体性肾小球炎；在电子显微镜下观察可见肾小球系膜区淀粉样物质沉积；免疫荧光染色显示λ轻链和κ轻链染色阴性。骨髓活组织检查未见浆细胞异常增生。最终，我们做出ANCA相关血管炎多血管炎继发AA型淀粉样变的诊断。

Abstract

Renal amyloidosis secondary to anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis is extremely rare. Here

we reported a 77-year-old woman with ANCA-associated vasculitis. Renal biopsy with Masson trichrome staining showed pauci-immune crescentic glomerulonephritis

and electron microscopy showed amyloid deposition in the mesangial area. Immunofluorescence revealed kappa light chain and lambda light chain negative. Bone marrow biopsy revealed no clonal plasma cell. Finally

she was diagnosed as ANCA-associated vasculitis with secondary renal amyloid A amyloidosis.

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references

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