新中国抗生素研发与工业化生产的不二功勋——张为申

于滨; 黄付敏; 汤国星; 刘静

doi:10.24920/004084

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新中国抗生素研发与工业化生产的不二功勋——张为申

中国医学科学杂志（英文版） 2022年37卷第3期页码：282-286

Historical Traces of Medicine | Updated：2024-04-10

- 新中国抗生素研发与工业化生产的不二功勋——张为申
- Affiliations：
  
  Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  *刘静 ljmarry@sina.com
- Funds：
  
  北京市社会科学基金重点项目“北京医学博物馆的历史文化与传播创新研究”(21LSA001)
- DOI：10.24920/004084
  中图分类号：
- 收稿日期：2022-03-17，
  
  录用日期：2022-7-12，
  
  网络出版日期：2022-09-22，
  
  纸质出版日期：2022-09-30
- Accepted：
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于滨, 黄付敏, 汤国星, 等. 新中国抗生素研发与工业化生产的不二功勋——张为申[J]. 中国医学科学杂志（英文版）, 2022,37(3):282-286.

Bin Yu, Fumin Huang, Guoxing Tang, et al. Zhang Weishen: A Pioneer in the Development and Industrial Production of Penicillin in New China[J]. Chinese medical sciences journal, 2022, 37(3): 282-286.
于滨, 黄付敏, 汤国星, 等. 新中国抗生素研发与工业化生产的不二功勋——张为申[J]. 中国医学科学杂志（英文版）, 2022,37(3):282-286. DOI： 10.24920/004084.

Bin Yu, Fumin Huang, Guoxing Tang, et al. Zhang Weishen: A Pioneer in the Development and Industrial Production of Penicillin in New China[J]. Chinese medical sciences journal, 2022, 37(3): 282-286. DOI： 10.24920/004084.

摘要

青霉素的研发在旧中国艰难起步

并取得了一定的成果。1951年

张为申作为唯一一位在美国青霉素研发中心接受培训和工作多年的华裔科学家

克服重重困难回到中国。1953年

在他和同事们的努力下

中国实现了青霉素的工业化生产

缓解了广大群众的燃眉之急。抗生素也成为新中国成立后第一个取得重大科技成果的学科。20世纪50年代中期

乳糖替代品国产化的技术突破

标志着产青霉素培养基原料的国产化

为中国特色青霉素的产业化生产铺平了道路。抗生素成为中国数亿患者使用率最高、价格最实惠的药物之一

中国从此结束了“东亚病夫”的屈辱历史。

Abstract

The research and development of penicillin started with difficulty before 1949 and achieved certain results. In 1951

after the founding of the People’s Republic of China

Zhang Weishen

as the only Chinese scientist who had been trained and worked in a penicillin research and development center in the United States for many years

overcame many difficulties and returned to China. In 1953

with the efforts of Zhang Weishen and his colleagues

China realized the industrialized production of penicillin

alleviating the urgent needs of the masses. Antibiotics has also become the first discipline to achieve major scientific and technological achievements after the founding of the New China. In the mid-1950s

the technical breakthrough in the localization of lactose substitutes marked the localization of the raw materials of the penicillin-producing culture medium

which paved the way for the industrialized production of penicillin with Chinese characteristics. Antibiotics have become one of the most widely used and affordable drugs for hundreds of millions of patients in China

and China has since ended the humiliating history of the “Sick Man of East Asia”.

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Keywords

references

Niu Yahua . Research and development of penicillin in China in the 1940s . Chinese Journal of Medical History 2001 ; 31 ( 3 ): 184 - 8 .

Yin CP , Xie W . China’s first batch of penicillin developed in Kunming . Yunnan Daily , December 31, 2010 .

Zhang WS , Huang DB , et al. Study on the production of penicillin by colorless Penicillium chrysogenum strain W49-133: I. Shake flask culture experiment using domestic raw cottonseed cake instead of corn steep liquor; Ⅱ. Replacement of corn steep liquor in fermenter with domestic raw cottonseed cake and refining of penicillin . Acta Microbiologica Sinica 1953 ; 1 ( 1 ): 57 - 63 .

Zhang WS . Highlights in the International Antimicrobial Conference . In: A Collection in Memory of Zhang Weishen . Beijing : China Science and Technology Press ; 2018 .

Zhang WS , Huang DB , Xu XY , et al. Study on the production of penicillin by Penicillium chrysogenum W49-133 - Ⅲ. The effect of adding lactose in portions into the fermenter on the production of penicillin; Ⅳ. The improvement of the culture and refinement methods in fermenter by replacing the lactose with raw starch . Acta Microbiologica Sinica 1956 ; 4 ( 1 ): 127 - 36 . doi: 10.13343/j.cnki.wsxb.1956.01.010 https://dx.doi.org/10.13343/j.cnki.wsxb.1956.01.010 . DOI: 10.13343/j.cnki.wsxb.1956.01.010 http://doi.org/10.13343/j.cnki.wsxb.1956.01.010

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