大麻素CB<sub>1</sub>受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

Kaveh Shahveisi; Seyedeh Marziyeh Hadi; Hamed Ghazvini; Mehdi Khodamoradi

doi:10.24920/004087

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大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

中国医学科学杂志（英文） 2023年38卷第1期页码：29-37

Original Article | Updated：2024-03-30

- 大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用
- Affiliations：
  
  1. 1Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851451, Iran
  2. 2Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran
  3. 3Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari 48175866, Iran
  4. 4Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari 48175866, Iran
  5. 5Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851451, Iran
- Author bio：
  
  *Mehdi Khodamoradi，E-mail：mehdi0khodamoradi@gmail.com
- Funds：
- DOI：10.24920/004087
  中图分类号：
- 收稿日期：2022-03-21，
  
  录用日期：2022-9-6，
  
  网络出版日期：2023-03-01，
  
  纸质出版日期：2023-03-31
- Accepted：
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Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, 等. 大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用[J]. 中国医学科学杂志（英文）, 2023,38(1):29-37.

Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, et al. Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats[J]. Chinese medical sciences journal, 2023, 38(1): 29-37.
Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, 等. 大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用[J]. 中国医学科学杂志（英文）, 2023,38(1):29-37. DOI： 10.24920/004087.

Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, et al. Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats[J]. Chinese medical sciences journal, 2023, 38(1): 29-37. DOI： 10.24920/004087.

摘要

目的

探讨大麻素CB1受体（cannabinoid CB1 receptor，CB1R）的拮抗作用是否会影响慢性快速眼动（chronically rapid eye movement，CRM）睡眠剥夺（CRM sleep-deprived，RSD）大鼠的新物体识别（novel object recognition，NOR）记忆。

方法

采用多平台技术对动物进行为期7天的慢性部分RSD范式的识别记忆检查。CB

R拮抗剂利莫那班（1mg/kg或3mg/kg，腹腔内注射）在记忆获取采样前一小时、在记忆巩固采样后即时或在NOR记忆提取测试阶段前至少一小时进行注射。为实现记忆再巩固，在第二个采样阶段完成后即时注射利莫那班。

结果

RSD损害了NOR记忆的获取、巩固和提取，但不影响NOR记忆的再巩固。注射利莫那班不影响记忆的获取、巩固和再巩固；然而，它减轻了慢性RSD对NOR记忆提取造成的损害。

结论

这些发现以及我们之前的报告似乎表明，RSD可能因其持续时间不同而影响识别记忆的不同阶段。重要的是，CB1R似乎至少部分参与了慢性RSD对NOR记忆的提取，但与NOR记忆的获取、巩固和再巩固无关。

Abstract

Objective

We aimed to investigate whether antagonism of the cannabinoid CB

receptor (CB

R) could affect novel object recognition (NOR) memory in chronically rapid eye movement sleep-deprived (RSD) rats.

Methods

The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform technique. The CB

R antagonist rimonaba

nt (1 or 3 mg/kg

i.p.) was administered either at one hour prior to the sample phase for acquisition

or immediately after the sample phase for consolidation

or at one hour before the test phase for retrieval of NOR memory. For the reconsolidation task

rimonabant was administered immediately after the second sample phase.

Results

The RSD episode impaired acquisition

consolidation

and retrieval

but it did not affect the reconsolidation of NOR memory. Rimonabant administration did not affect acquisition

consolidation

and reconsolidation; however

it attenuated impairment of the retrieval of NOR memory induced by chronic RSD.

Conclusions

These findings

along with our previous report

would seem to suggest that RSD may affect different phases of recognition memory based on its duration. Importantly

it seems that the CB

R may

at least in part

be involved in the adverse effects of chronic RSD on the retrieval

but not in the acquisition

consolidation

and reconsolidation

of NOR memory.

关键词

Keywords

references

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大麻素CB1受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

DOI：10.24920/004087

摘要

Abstract

关键词

Keywords

references

大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用