肺型原发性卵巢小细胞癌：6例病例分析及31例文献回顾

陈旭; 刘红玲; 王金穗; 赵凤辉

doi:10.24920/004183

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肺型原发性卵巢小细胞癌：6例病例分析及31例文献回顾

中国医学科学杂志（英文） 2023年38卷第2期页码：130-137

Original article | Updated：2024-06-12

- 肺型原发性卵巢小细胞癌：6例病例分析及31例文献回顾
- Affiliations：
  
  1. 1Department of Pathology, Gansu Provincial Hospital, Lanzhou 730000, China
  2. 2Department of Occupational Medicine, Third Gansu Provincial Hospital, Lanzhou 730000, China
- Author bio：
  
  *zhaofh0931@163.com
- Funds：
- DOI：10.24920/004183
  中图分类号：
- 收稿日期：2022-10-18，
  
  录用日期：2023-04-28，
  
  网络出版日期：2023-06-06，
  
  纸质出版日期：2023-06-30
- Accepted：
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陈旭, 刘红玲, 王金穗, 等. 肺型原发性卵巢小细胞癌：6例病例分析及31例文献回顾[J]. 中国医学科学杂志（英文）, 2023,38(2):130-137.

Xu Chen, Hong-Ling Liu, Jin-Sui Wang, et al. Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures[J]. Chinese medical sciences journal, 2023, 38(2): 130-137.
陈旭, 刘红玲, 王金穗, 等. 肺型原发性卵巢小细胞癌：6例病例分析及31例文献回顾[J]. 中国医学科学杂志（英文）, 2023,38(2):130-137. DOI： 10.24920/004183.

Xu Chen, Hong-Ling Liu, Jin-Sui Wang, et al. Primary Ovarian Small Cell Carcinoma of Pulmonary Type: Analysis of 6 Cases and Review of 31 Cases in the Literatures[J]. Chinese medical sciences journal, 2023, 38(2): 130-137. DOI： 10.24920/004183.

摘要

目的

肺型原发性卵巢小细胞癌（primary small cell ovarian cancer of pulmonary type，SCCOPT）是一种预后不良的罕见卵巢肿瘤。目前，以铂类为基础的方案是其化疗的标准方案。由于发病率低，有关SCCOPT的临床特点以及其他治疗方法的潜在益处的研究较少。本研究总结了SCCOPT的临床病理特征和治疗。

方法

我们对2008年至2022年在甘肃省人民医院诊断的6例SCCOPT患者以及17篇英文文献和3篇中文文献报道的31例患者的临床、影像学、实验室和病理学特征进行了回顾性分析。

结果

患者的中位年龄为56.00岁。大约80%的患者处于Ⅲ或Ⅳ期。在手术和术后化疗后，患者的预后不良，中位总生存期为12个月。瘤体为囊实性，显微镜下可见小圆形肿瘤细胞和坏死。免疫组织化学检测显示：SCCOPT均表达上皮标志物—CD56和Y染色体相关性高迁移群盒2（sex-determining region of Y chromosom

e-related high-mobility-group box 2，SOX-2），不表达雌激素受体、孕激素受体、波形蛋白、Leu-7和生长抑素受体2。超过80%的肿瘤表达突触素。只有少数肿瘤表达神经元特异性烯醇酶、嗜铬粒蛋白A和甲状腺转录因子-1。

结论

SCCOPT预后不良。SOX-2有可能成为诊断SCCOPT的生物标记物。

Abstract

Objective

Primary ovarian small cell carcinoma of pulmonary type (SCCOPT) is a rare ovarian tumor with a poor prognosis. The platinum-based chemotherapy is the standard treatment. However

there is little research on the clinical characteristics of SCCOPT and the potential benefits of other treatments due to its low incidence. The study aims to investigate clinicopathological characteristics and treatment of SCCOPT.

Methods

We summarized the clinical

imaging

laboratorical and pathological characteristics of 37 SCCOPT cases

in which 6 cases were admitted to the Gansu Provincial Hospital from the year of 2008 to 2022 and 31 cases reported in 17 English and 3 Chinese literatures.

Results

The median age of the studied SCCOPT cases (

=37) was 56.00 (range

22-80) years. Almost 80% of them had a stage Ⅲ or Ⅳ tumor. All patients underwent an operation and postoperative chemotherapy. Nevertheless

all cases had a poor prognosis

with a median overall survival time of 12 months. Immunohistochemically

the SCCOPT of all patients showed positive expressions of epithelial markers

such as CD56 and sex-determining region of Y chromosome-related high-mobility-group box 2 (SOX-2)

and negative expressions of estrogen receptor

progesterone receptor

vimentin

Leu-7

and somatostatin receptor 2. The tumor of above 80% cases expressed synaptophysin. Only a few cases expressed neuron-specific enolase

chromogranin A

and thyroid transcription factor-1.

Conclusions

SCCOPT had a poor prognosis. SOX-2 could be a biomarker to be used to diagnose SCCOPT.

关键词

Keywords

references

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