度普利尤单抗治疗食物依赖运动诱发严重过敏反应

朱丽萍; 汤蕊; 王青; 李宏

doi:10.24920/004208

Your Location：

Home >

Browse articles >

度普利尤单抗治疗食物依赖运动诱发严重过敏反应

中国医学科学杂志（英文） 2023年38卷第2期页码：159-162

Case Report | Updated：2024-06-12

- 度普利尤单抗治疗食物依赖运动诱发严重过敏反应
- Affiliations：
  
  Allergy Department, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China
- Author bio：
  
  *Hong Li, E-mail: lihong@pumch.cn.
- Funds：
- DOI：10.24920/004208
  中图分类号：
- 收稿日期：2023-01-28，
  
  录用日期：2023-04-24，
  
  网络出版日期：2023-05-18，
  
  纸质出版日期：2023-06-30
- Accepted：
Scan QR Code
朱丽萍, 汤蕊, 王青, 等. 度普利尤单抗治疗食物依赖运动诱发严重过敏反应[J]. 中国医学科学杂志（英文）, 2023,38(2):159-162.

Li-Ping Zhu, Rui Tang, Qing Wang, et al. Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case[J]. Chinese medical sciences journal, 2023, 38(2): 159-162.
朱丽萍, 汤蕊, 王青, 等. 度普利尤单抗治疗食物依赖运动诱发严重过敏反应[J]. 中国医学科学杂志（英文）, 2023,38(2):159-162. DOI： 10.24920/004208.

Li-Ping Zhu, Rui Tang, Qing Wang, et al. Dupilumab for Treatment of Food-Dependent, Exercise-Induced Anaphylaxis: Report of One Case[J]. Chinese medical sciences journal, 2023, 38(2): 159-162. DOI： 10.24920/004208.

摘要

食物依赖运动诱发严重过敏反应（food-dependent

exercise-induced anaphylaxis，FDEIA）是一种潜在可威胁患者生命的过敏性疾病，常在进食可疑致敏食物数小时内运动时发作。该病极罕见，患病率约为0.02%，目前尚无预防方法。现报告一例度普利尤单抗治疗11岁FDEIA患儿。该患儿在就诊前2年内发生了10余次不明原因的严重过敏反应，常规治疗后症状未获控制。后在我科行7次度普利尤单抗皮下注射治疗，为期33周。在第7次治疗时被诊断为菌菇引发的FDEIA。度普利尤单抗治疗期间，患儿每月至少有2次在进食蘑菇数小时内进行运动，但未再发严重过敏反应。目前尚未见报告阐明度普利尤单抗治疗食物诱导的IgE型严重过敏反应的临床意义，尤其是对于FDEIA这种罕见疾病。因此，本病例或可为儿童严重过敏反应症状的控制和改善提供新的治疗思路。

Abstract

Food-dependent

exercise-induced anaphylaxis (FDEIA) is a potentially life-threatening disorder that often occurs with exercise

and patients typically have eaten a specific food within hours before disease onset. This disease is exceedingly rare

with a prevalence of 0.02%. No well-recognized prevention or treatment strategy has been available for FDEIA except avoiding triggers strictly. Here we report an 11-year-old boy with a history of recurrent anaphylaxis of unknown etiology more than 10 times within two years. As the anaphylactic symptoms had not been controlled after traditional treatments

the patient was given subcutaneous injection of dupilumab seven times within 33 weeks. During dupilumab treatments

the patient was exposed to culprit mushrooms plus exercises at least twice a month but without notable anaphylaxis. Thus

Dupilumab may improve the allergic reactions in FDEIA patients.

关键词

Keywords

references

Schwartz LB , Delgado L , Craig T , et al . Exercise-induced hypersensitivity syndromes in recreational and competitive athletes: a PRACTALL consensus report (what the general practitioner should know about sports and allergy) . Allergy 2008 ; 63 ( 8 ): 953 - 61 . doi: 10.1111/j.1398-9995.2008.01802.x https://dx.doi.org/10.1111/j.1398-9995.2008.01802.x . DOI: 10.1111/j.1398-9995.2008.01802.x http://doi.org/10.1111/j.1398-9995.2008.01802.x

Manabe T , Oku N , Aihara Y . Food-dependent exercise-induced anaphylaxis among junior high school students: a 14-year epidemiological comparison . Allergol Int 2015 ; 64 ( 3 ): 285 - 6 . doi: 10.1016/j.alit.2015.01.007 https://dx.doi.org/10.1016/j.alit.2015.01.007 . DOI: 10.1016/j.alit.2015.01.007 http://doi.org/10.1016/j.alit.2015.01.007

Muñoz-Bellido FJ , Moreno E , Dávila I . Dupilumab: A review of present indications and off-label uses . J Investig Allergol Clin Immunol 2022 ; 32 ( 2 ): 97 - 115 . doi: 10.18176/jiaci.0682 https://dx.doi.org/10.18176/jiaci.0682 . DOI: 10.18176/jiaci.0682 http://doi.org/10.18176/jiaci.0682 http://www.jiaci.org/ http://www.jiaci.org/

Otani T , Iwamoto H , Horimasu Y , et al . Effect of dupilumab in a patient with severe asthma complicated with recurrent anaphylaxis: a case report . J Investig Allergol Clin Immunol 2023 ; 33 ( 3 ). doi: 10.18176/jiaci.0840 https://dx.doi.org/10.18176/jiaci.0840 . DOI: 10.18176/jiaci.0840 http://doi.org/10.18176/jiaci.0840

Cardona V , Ansotegui IJ , Ebisawa M , et al . World allergy organization anaphylaxis guidance 2020 . World Allergy Organ J 2020 ; 13 ( 10 ): 100472 . doi: 10.1016/j.waojou.2020.100472 https://dx.doi.org/10.1016/j.waojou.2020.100472 . DOI: 10.1016/j.waojou.2020.100472 http://doi.org/10.1016/j.waojou.2020.100472

Brockow K , Kneissl D , Valentini L , et al . Using a gluten oral food challenge protocol to improve diagnosis of wheat-dependent exercise-induced anaphylaxis . J Allergy Clin Immunol 2015 ; 135 ( 4 ): 977 - 84 . e4 . doi: 10.1016/j.jaci.2014.08.024 https://dx.doi.org/10.1016/j.jaci.2014.08.024 . DOI: 10.1016/j.jaci.2014.08.024 http://doi.org/10.1016/j.jaci.2014.08.024

Hanakawa Y , Tohyama M , Shirakata Y , et al . Food-dependent exercise-induced anaphylaxis: a case related to the amount of food allergen ingested . Br J Dermatol 1998 ; 138 ( 5 ): 898 - 900 . doi: 10.1046/j.1365-2133.1998.02254.x https://dx.doi.org/10.1046/j.1365-2133.1998.02254.x . DOI: 10.1046/j.1365-2133.1998.02254.x http://doi.org/10.1046/j.1365-2133.1998.02254.x

Jiang NN , Wen LP , Li H , et al . A New Diagnostic Criteria of Wheat-Dependent, Exercise-Induced Anaphylaxis in China . Chin Med J (Engl) 2018 ; 131 ( 17 ): 2049 - 54 . doi: 10.4103/0366-6999.239304 https://dx.doi.org/10.4103/0366-6999.239304 . DOI: 10.4103/0366-6999.239304 http://doi.org/10.4103/0366-6999.239304

Jiang N , Yin J , Wen L , et al . Characteristics of anaphylaxis in 907 chinese patients referred to a tertiary allergy center: a retrospective study of 1,952 episodes . Allergy Asthma Immunol Res 2016 ; 8 ( 4 ): 353 - 61 . doi: 10.4168/aair.2016.8.4.353 https://dx.doi.org/10.4168/aair.2016.8.4.353 . DOI: 10.4168/aair.2016.8.4.353 http://doi.org/10.4168/aair.2016.8.4.353 https://e-aair.org/DOIx.php?id=10.4168/aair.2016.8.4.353 https://e-aair.org/DOIx.php?id=10.4168/aair.2016.8.4.353

Bian S , Zhang P , Li L , et al . Anaphylaxis associated with allergen specific immunotherapy, omalizumab, and dupilumab: a real world study based on the US Food and Drug Administration Adverse Event Reporting System . Front Pharmacol 2021 ; 12 : 767999 . doi: 10.3389/fphar.2021.767999 https://dx.doi.org/10.3389/fphar.2021.767999 . DOI: 10.3389/fphar.2021.767999 http://doi.org/10.3389/fphar.2021.767999 https://www.frontiersin.org/articles/10.3389/fphar.2021.767999/full https://www.frontiersin.org/articles/10.3389/fphar.2021.767999/full

Li L , Wang Z , Cui L , et al . Anaphylactic risk related to omalizumab, benralizumab, reslizumab, mepolizumab, and dupilumab . Clin Transl Allergy 2021 ; 11 ( 4 ): e12038 . doi: 10.1002/clt2.12038 https://dx.doi.org/10.1002/clt2.12038 . DOI: 10.1002/clt2.12038 http://doi.org/10.1002/clt2.12038

Niggemann B , Beyer K . Factors augmenting allergic reactions . Allergy 2014 ; 69 ( 12 ): 1582 - 7 . doi: 10.1111/all.12532 https://dx.doi.org/10.1111/all.12532 . DOI: 10.1111/all.12532 http://doi.org/10.1111/all.12532

Yamauchi T , Sasaki S , Lee ES , et al . Dupilumab treatment ameliorates clinical and hematological symptoms, including blood eosinophilia, in patients with atopic dermatitis . Int J Dermatol 2021 ; 60 ( 2 ): 190 - 5 . doi: 10.1111/ijd.15183 https://dx.doi.org/10.1111/ijd.15183 . DOI: 10.1111/ijd.15183 http://doi.org/10.1111/ijd.15183

Burton OT , Darling AR , Zhou JS , et al . Direct effects of IL-4 on mast cells drive their intestinal expansion and increase susceptibility to anaphylaxis in a murine model of food allergy . Mucosal Immunol 2013 ; 6 ( 4 ): 740 - 50 . doi: 10.1038/mi.2012.112 https://dx.doi.org/10.1038/mi.2012.112 . DOI: 10.1038/mi.2012.112 http://doi.org/10.1038/mi.2012.112

Dispenza MC , Krier-Burris RA , Chhiba KD , et al . Bruton's tyrosine kinase inhibition effectively protects against human IgE-mediated anaphylaxis . J Clin Invest 2020 ; 130 ( 9 ): 4759 - 70 . doi: 10.1172/JCI138448 https://dx.doi.org/10.1172/JCI138448 . DOI: 10.1172/JCI138448 http://doi.org/10.1172/JCI138448

Tanno LK , Simons FER , Sanchez-Borges M , et al . Applying prevention concepts to anaphylaxis: A call for worldwide availability of adrenaline auto-injectors . Clin Exp Allergy 2017 ; 47 ( 9 ): 1108 - 14 . doi: 10.1111/cea.12973 https://dx.doi.org/10.1111/cea.12973 . DOI: 10.1111/cea.12973 http://doi.org/10.1111/cea.12973

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据