FOLLOWUS
- Share with wechat friends or circle of friends
红参水提液对大鼠体内阿司匹林代谢物的药代动力学影响
- Affiliations：
北京中医药大学 中药学院中药制药系,北京 100029 中国
- Author bio：
* Tel: 86-10-84738615, E-mail: landocean28@163.com
- Funds：
DOI：10.24920/11806
中图分类号：收稿日期：2017-07-23，
网络出版日期：2018-06-20，
纸质出版日期：2018-06-20
- Accepted：
Scan QR Code
薛宇涛, 谭宁, 喻刚艳, 等. 红参水提液对大鼠体内阿司匹林代谢物的药代动力学影响[J]. Chinese Medical Sciences Journal, 2018,33(2):107-113.
Xue Yutao, Tan Ning, Yu Gangyan, et al. Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats[J]. Chinese medical sciences journal, 2018, 33(2): 107-113.
薛宇涛, 谭宁, 喻刚艳, 等. 红参水提液对大鼠体内阿司匹林代谢物的药代动力学影响[J]. Chinese Medical Sciences Journal, 2018,33(2):107-113. DOI： 10.24920/11806.
Xue Yutao, Tan Ning, Yu Gangyan, et al. Effect of Red Ginseng Extract on the Pharmacokinetics of Aspirin Metabolite in Sprague Dawley Rats[J]. Chinese medical sciences journal, 2018, 33(2): 107-113. DOI： 10.24920/11806.
摘要
目的
探讨红参与阿司匹林联用对大鼠体内阿司匹林代谢物的药代动力学影响。
方法
12只雄性SD大鼠随机均分为阿司匹林单用组（阿司匹林10.42 mg/kg）和红参、阿司匹林联用组（红参提取物0.5 mg/g + 阿司匹林10.42 mg/kg）。经灌胃给药。分别于灌胃前及灌胃后0.083
0.25
0.5
1
2
4
6
8
10及12 h经眼眶取血0.5 ml
采用HPLC-UV分析大鼠血浆中阿司匹林代谢物——水杨酸的血药浓度
采用DAS3.0软件的非房室模型计算水杨酸的药代动力学参数
并对两组的参数进行比较。
结果
与阿司匹林单用组相比
联用组的水杨酸最大血药浓度和药时曲线下面积显著增加（P
<
0.01）
清除率显著降低（P
<
0.05）。
结论
红参可能具有促进阿司匹林在大鼠体内吸收
延缓其代谢产物——水杨酸代谢的作用。
Abstract
Objective
To investigate whether red ginseng extract can affect the pharmacokinetics of aspirin in Sprague Dawley (SD) rats.
Methods
Totally
12 male SD rats were randomly and uniformly divided into the aspirin group (aspirin 10.42 mg·kg
-1
) and the combined group (red ginseng extraction 0.5 mg·g
-1
+ aspirin 10.42 mg·kg
-1
). After intragastric administration of drugs
blood samples (0.5 ml once) were drawn from orbit at 0.083
0.25
0.5
1
2
4
6
8
10 and 12 hours after dosing. Plasma concentration of salicylic acid (metabolite of aspirin) was detected with ultraviolet-visible high performance liquid chromatography (HPLC). The reliability of the procedure was verified with respect to specificity
linearity
accuracy
precision
extraction recovery and matrix effect
and stability. Pharmacokinetics of salicylic acid was evaluated by using non-compartmental model.
Results
The method was proved to be validated. Compared with the aspirin group
area under the curve (AUC
0-t
) and maximum concentration of salicylic acid in rats of the combined group increased obviously (
P
<
0.01)
while clearance rate (CL
z
/F) decreased clearly (
P
<
0.05).
Conclusion
The
in vivo
study showed that red ginseng extract can help the internal absorption of aspirin
and delay the
in vivo
metabolism of aspirin.
关键词
Keywords
references
Collaborators M C O D . Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013 . Lancet 2015 ; 385 ( 9963 ): 117 - 71 . doi: 10.1016/S0140-6736(14)61682-2 10.1016/S0140-6736(14)61682-2 . DOI: 10.1016/S0140-6736(14)61682-2 http://doi.org/10.1016/S0140-6736(14)61682-2 http://linkinghub.elsevier.com/retrieve/pii/S0140673614616822 http://linkinghub.elsevier.com/retrieve/pii/S0140673614616822
Baigent C , Kappelle LJ , Algra A , et al . Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients . BMJ 2002 ; 324 ( 7329 ): 71 - 86 . doi: 10.1136/bmj.324.7329.71 10.1136/bmj.324.7329.71 . DOI: 10.1136/bmj.324.7329.71 http://doi.org/10.1136/bmj.324.7329.71 http://www.bmj.com/cgi/doi/10.1136/bmj.324.7329.71 http://www.bmj.com/cgi/doi/10.1136/bmj.324.7329.71
Antithrombotic Trialists’ ( ATT) Collaboration. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomized trials . Lancet 2009 ; 373 ( 9678 ): 1849 - 60 . doi: 10.1016/S0140-6736(09)60503-1 10.1016/S0140-6736(09)60503-1 . DOI: 10.1016/S0140-6736(09)60503-1 http://doi.org/10.1016/S0140-6736(09)60503-1 http://linkinghub.elsevier.com/retrieve/pii/S0140673609605031 http://linkinghub.elsevier.com/retrieve/pii/S0140673609605031
Baigent C . For and against: aspirin for everyone older than 50? Against . BMJ 2005 ; 330 ( 7505 ): 1440 - 1 . doi: 10.1136/bmj.330.7505.1442 10.1136/bmj.330.7505.1442 . DOI: 10.1136/bmj.330.7505.1440 http://doi.org/10.1136/bmj.330.7505.1440 http://www.bmj.com/lookup/doi/10.1136/bmj.330.7505.1440 http://www.bmj.com/lookup/doi/10.1136/bmj.330.7505.1440
Bulugahapitiya U , Siyambalapitiya S , Sithole J , et al . Age threshold for vascular prophylaxis by aspirin in patients without diabetes . Heart 2008 ; 94 ( 11 ): 1429 - 32 . doi: 10.1136/hrt.2008.150698 10.1136/hrt.2008.150698 . DOI: 10.1136/hrt.2008.150698 http://doi.org/10.1136/hrt.2008.150698 http://heart.bmj.com/cgi/doi/10.1136/hrt.2008.150698 http://heart.bmj.com/cgi/doi/10.1136/hrt.2008.150698
Dehmer SP , Maciosek MV , Flottemesch TJ , et al . Aspirin for the primary prevention of cardiovascular disease and colorectal cancer: a decision analysis for the U.S. preventive services task force . Ann Intern Med 2016 ; 164 ( 12 ): 777 - 86 . doi: 10.7326/M15-2129 10.7326/M15-2129 . DOI: 10.7326/M15-2129 http://doi.org/10.7326/M15-2129 http://annals.org/article.aspx?doi=10.7326/M15-2129 http://annals.org/article.aspx?doi=10.7326/M15-2129
Tian ZH , Pang HH , Du SY , et al . Effect of panax notoginseng saponins on the pharmacokinetics of aspirin in rats . J Chromatogr B Analyt Technol Biomed Life Sci 2017 ; 1040 : 136 - 43 . doi: 10.1016/j.jchromb.2016.12.007 10.1016/j.jchromb.2016.12.007 . DOI: 10.1016/j.jchromb.2016.12.007 http://doi.org/10.1016/j.jchromb.2016.12.007 http://linkinghub.elsevier.com/retrieve/pii/S1570023216313757 http://linkinghub.elsevier.com/retrieve/pii/S1570023216313757
Chen WK , Ju WZ , . Effects of mailuoning injection in combination with aspirin on salicylic acid pharmacokinetics in rats . Pharm Clin Res 2009 ; 17 ( 4 ): 283 - 6 . Chinese. doi: 10.13664/j.cnki.pcr.2009.04.013 10.13664/j.cnki.pcr.2009.04.013 . http://en.cnki.com.cn/Article_en/CJFDTOTAL-YXLY200904005.htm http://en.cnki.com.cn/Article_en/CJFDTOTAL-YXLY200904005.htm
Cheng ZM . The study on public recognition of processed ginseng’s health-care effects [dissertation] . Beijing: China Academy of Chinese Medical Sciences , 2012 .
Jin L , Cho JY , Kim WK . Anti-inflammation effect of exercise and Korean red ginseng in aging model rats with diet-induced atherosclerosis . Nutr Res Pract 2014 ; 8 ( 3 ): 284 - 91 . doi: 10.4162/nrp.2014.8.3.284 10.4162/nrp.2014.8.3.284 . DOI: 10.4162/nrp.2014.8.3.284 http://doi.org/10.4162/nrp.2014.8.3.284 https://synapse.koreamed.org/DOIx.php?id=10.4162/nrp.2014.8.3.284 https://synapse.koreamed.org/DOIx.php?id=10.4162/nrp.2014.8.3.284
Kwak YS , Kyung JS , Kim JS , et al . Anti-hyperlipidemic effects of red ginseng acidic polysaccharide from Korean red ginseng . Biol Pharm Bull 2010 ; 33 ( 3 ): 468 - 72 . doi: 10.1248/bpb.33.468 10.1248/bpb.33.468 . DOI: 10.1074/jbc.M405786200 http://doi.org/10.1074/jbc.M405786200 http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/33.468?from=CrossRef http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/33.468?from=CrossRef
Jin YR , Yu JY , Lee JJ , et al . Antithrombotic and antiplatelet activities of Korean red ginseng extract . Basic Clin Pharmacol Toxicol 2007 ; 100 ( 3 ): 170 - 5 . doi: 10.1111/j.1742-7843.2006.00033.x 10.1111/j.1742-7843.2006.00033.x . DOI: 10.1111/j.1742-7843.2006.00033.x http://doi.org/10.1111/j.1742-7843.2006.00033.x http://www.blackwell-synergy.com/toc/pto/100/3 http://www.blackwell-synergy.com/toc/pto/100/3
Lee HS , Kim MR , Park Y , et al . Fermenting red ginseng enhances its safety and efficacy as a novel skin care anti-aging ingredient: in vitro and animal study . J Med Food 2012 ; 15 ( 11 ): 1015 - 23 . doi: 10.1089/jmf.2012.2187 10.1089/jmf.2012.2187 . DOI: 10.1089/jmf.2012.2187 http://doi.org/10.1089/jmf.2012.2187 http://online.liebertpub.com/doi/abs/10.1089/jmf.2012.2187 http://online.liebertpub.com/doi/abs/10.1089/jmf.2012.2187
Hong CE , Lyu SY . Anti-inflammatory and anti-oxidative effects of Korean red ginseng extract in human keratinocytes . Immune Netw 2011 ; 11 ( 1 ): 42 - 9 . doi: 10.4110/in.2011.11.1.42 10.4110/in.2011.11.1.42 . DOI: 10.4110/in.2011.11.1.42 http://doi.org/10.4110/in.2011.11.1.42 https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2011.11.1.42 https://synapse.koreamed.org/DOIx.php?id=10.4110/in.2011.11.1.42
Jinya LU , Chen J , . Clinical efficacy of shexiang baoxin pill combined with aspirin in treating elder patients with coronary heart disease . Jiangsu Med J 2015 ; 41 ( 1 ): 44 - 7 . Chinese. doi: 10.19460/j.cnki.0253-3685.2015.01.016 10.19460/j.cnki.0253-3685.2015.01.016 . http://www.en.cnki.com.cn/Article_en/CJFDTotal-YIYA201501017.htm http://www.en.cnki.com.cn/Article_en/CJFDTotal-YIYA201501017.htm
. The clinical effect of xuesaitong combined with aspirin in acute cerebral infarction . J Aerospace Med 2016 ; 27 ( 4 ): 428 - 9 . Chinese. doi: 10.3969/j.issn.2095-1434.2016.04.011 10.3969/j.issn.2095-1434.2016.04.011 . http://www.en.cnki.com.cn/Article_en/CJFDTotal-HKHT201604013.htm http://www.en.cnki.com.cn/Article_en/CJFDTotal-HKHT201604013.htm
. Pharmacokinetics of aspirin after single and multiple doses in healthy subjects . Chin J New Drugs 2006 ; 15 ( 16 ): 1393 - 6 . Chinese. doi: 10.3321/j.issn:1003-3734.2006.16.022 10.3321/j.issn:1003-3734.2006.16.022 . DOI: 10.1360/aps040120 http://doi.org/10.1360/aps040120 http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZXYZ200616026.htm http://en.cnki.com.cn/Article_en/CJFDTOTAL-ZXYZ200616026.htm
Ijaz A , Bhatti HN , Rasheed S , et al . Pharmacokinetic study of aspirin in healthy female volunteers . Pak J Bio Sci 2003 ; 6 ( 16 ): 1404 - 7 . doi: 10.3923/pjbs.2003.1404.1407 10.3923/pjbs.2003.1404.1407 . DOI: 10.3923/pjbs.2003.1404.1407 http://doi.org/10.3923/pjbs.2003.1404.1407 http://www.scialert.net/abstract/?doi=pjbs.2003.1404.1407 http://www.scialert.net/abstract/?doi=pjbs.2003.1404.1407
Jacob MC , Favre M , Bensa JC . Membrane cell permeabilization with saponin and multiparametric analysis by flow cytometry . Cytometry A 1991 ; 12 ( 6 ): 550 - 8 . doi: 10.1002/cyto.990120612 10.1002/cyto.990120612 . DOI: 10.1002/cyto.990120612 http://doi.org/10.1002/cyto.990120612 http://doi.wiley.com/10.1002/%28ISSN%291097-0320 http://doi.wiley.com/10.1002/%28ISSN%291097-0320
Sim JS , Zhao HL , Li DW , et al . Effects of saponins from the root bark of aralia elata on the transport of chondroitin sulfate in caco-2 cell monolayers and rats . Biol Pharm Bull 2005 ; 28 ( 6 ): 1043 - 8 . doi: 10.1248/bpb.28.1043 10.1248/bpb.28.1043 . DOI: 10.1248/bpb.28.1043 http://doi.org/10.1248/bpb.28.1043 http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/28.1043?from=CrossRef http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/28.1043?from=CrossRef
Wang B , Wang J , Huang SQ , et al . Genetic polymorphism of the human cytochrome p450 2c9 gene and its clinical significance . Curr Drug Metab 2009 ; 10 ( 7 ): 781 - 834 . doi: 10.2174/138920009789895480 10.2174/138920009789895480 . DOI: 10.2174/138920009789895480 http://doi.org/10.2174/138920009789895480 <![CDATA[http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2002&volume=10&issue=7&spage=781]]> <![CDATA[http://www.eurekaselect.com/openurl/content.php?genre=article&issn=1389-2002&volume=10&issue=7&spage=781]]>
Agúndez JA , Garcíamartín E , Martínez C . Genetically based impairment in cyp2c8- and cyp2c9-dependent nsaid metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine? Expert Opin Drug Metab Toxicol 2009 ; 5 ( 6 ): 607 - 20 . doi: 10.1517/17425250902970998 10.1517/17425250902970998 . DOI: 10.1517/17425250902970998 http://doi.org/10.1517/17425250902970998 http://www.tandfonline.com/doi/full/10.1517/17425250902970998 http://www.tandfonline.com/doi/full/10.1517/17425250902970998
He N , Edeki T . The inhibitory effects of herbal components on cyp2c9 and cyp3a4 catalytic activities in human liver microsomes . Am J Ther 2004 ; 11 ( 3 ): 206 - 12 . doi: 10.1097/00045391-200405000-00009 10.1097/00045391-200405000-00009 . DOI: 10.1097/00045391-200405000-00009 http://doi.org/10.1097/00045391-200405000-00009 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00045391-200405000-00009 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00045391-200405000-00009
Derry S , Loke YK . Risk of gastrointestinal haemorrhage with long term use of aspirin: meta-analysis . BMJ 2000 ; 321 ( 7270 ): 1183 - 7 . doi: 10.1136/bmj.321.7270.1183 10.1136/bmj.321.7270.1183 . DOI: 10.1136/bmj.321.7270.1183 http://doi.org/10.1136/bmj.321.7270.1183 http://www.bmj.com/cgi/doi/10.1136/bmj.321.7270.1183 http://www.bmj.com/cgi/doi/10.1136/bmj.321.7270.1183
Sørensen HT , Mellemkjær L , Blot WJ , et al . Risk of upper gastrointestinal bleeding associated with use of low-dose aspirin . Am J Gastroenterol 2000 ; 95 ( 9 ): 2218 - 24 . doi: 10.1016/S0002-9270(00)0104-06 10.1016/S0002-9270(00)0104-06 . DOI: 10.1111/ajg.2000.95.issue-9 http://doi.org/10.1111/ajg.2000.95.issue-9 http://www.blackwell-synergy.com/toc/ajg/95/9 http://www.blackwell-synergy.com/toc/ajg/95/9
Huang ES , Strate LL , Ho WW , et al . Long-term use of aspirin and the risk of gastrointestinal bleeding . Am J Med 2011 ; 124 ( 5 ): 426 - 33 . doi: 10.1016/j.amjmed.2010.12.022 10.1016/j.amjmed.2010.12.022 . DOI: 10.1016/j.amjmed.2010.12.022 http://doi.org/10.1016/j.amjmed.2010.12.022 http://linkinghub.elsevier.com/retrieve/pii/S0002934311000957 http://linkinghub.elsevier.com/retrieve/pii/S0002934311000957
关联资源
相关文章
相关作者
相关机构
- © 2024 中国医学科学院 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies