合并冠心病的静脉血栓栓塞症患者的抗栓治疗

周梦馨; 孙蕊; 陈跃鑫

doi:10.24920/21805

Your Location：

Home >

Browse articles >

合并冠心病的静脉血栓栓塞症患者的抗栓治疗

Chinese Medical Sciences Journal 2018年33卷第2期页码：120-126

Review | Updated：2024-04-10

- 合并冠心病的静脉血栓栓塞症患者的抗栓治疗
- Affiliations：
  
  中国医学科学院北京协和医学院,北京协和医院血管外科, 北京 100730 中国
- Author bio：
  
  * E-mail: cyuexin@163.com; Fax: 86-10-69152506.
- Funds：
- DOI：10.24920/21805
  中图分类号：
- 收稿日期：2017-08-08，
  
  网络出版日期：2018-06-20，
  
  纸质出版日期：2018-06-20
- Accepted：
Scan QR Code
周梦馨, 孙蕊, 陈跃鑫. 合并冠心病的静脉血栓栓塞症患者的抗栓治疗[J]. Chinese Medical Sciences Journal, 2018,33(2):120-126.

Zhou Mengxin, Sun Rui, Chen Yuexin. A Literature Review of Antithrombotic Therapy for Patients of Venous Thromboembolic Events with Comorbidity of Coronary Heart Disease[J]. Chinese medical sciences journal, 2018, 33(2): 120-126.
周梦馨, 孙蕊, 陈跃鑫. 合并冠心病的静脉血栓栓塞症患者的抗栓治疗[J]. Chinese Medical Sciences Journal, 2018,33(2):120-126. DOI： 10.24920/21805.

Zhou Mengxin, Sun Rui, Chen Yuexin. A Literature Review of Antithrombotic Therapy for Patients of Venous Thromboembolic Events with Comorbidity of Coronary Heart Disease[J]. Chinese medical sciences journal, 2018, 33(2): 120-126. DOI： 10.24920/21805.

摘要

合并静脉血栓栓塞症(VTE)和冠心病(CHD)的患者在临床上并不少见。治疗这类患者的主要挑战是针对VTE和CHD的抗栓治疗原则不尽相同

如果联合用药则增加出血风险。因此应根据患者疾病情况评估疗效和出血风险

以选用最佳抗栓治疗方案。本文讨论了同时合并VTE和CHD的患者在不同情况下

如何根据病情和出血风险

选择相应的抗栓治疗

包括联合抗凝药物治疗、双联抗血小板治疗、三联抗栓治疗、溶栓治疗及后续长期治疗

以期为这类患者制定规范的、安全而有效的治疗方案提供参考。同时

本文还就新型口服抗凝药的应用及出血风险的评估方法进行了展望。

Abstract

Patients with venous thromboembolism (VTE) and concurrent coronary heart disease (CHD) are not rare in clinic. The main challenge in the treatment for these patients is that the antithrombotic therapies for VTE and CHD are different from each other

but the combination of the two therapeutic strategies would increase the risk of bleeding. There is a need to optimize the antithrombotic therapeutic scheme on the basis of individual conditional

in order to balance the therapeutic effects and the bleeding risk. This article discussed the appropriate antithrombotic therapy when balancing the effectiveness and the risk in different circumstance of concurrence of VTE and CHD

such as combining anticoagulation therapy

dual antiplatelet therapy (DAPT)

triple antithrombotic therapy (TAT)

thrombolytic therapy and extending therapy

in order to provide safe

standard and effective therapeutic schemes for the clinical management of these patients. In the meantime

this article also provides perspectives regarding the application of novel non-vitamin K anticoagulants (NOACs) and the assessment tools of bleeding risk.

关键词

Keywords

references

Cheuk BL , Cheung GC , Cheng SW . Epidemiology of venous thromboembolism in a Chinese population . Br J Surg 2004 ; 91 ( 4 ): 424 - 8 . doi: 10.1002/bjs.4454 10.1002/bjs.4454 . DOI: 10.1002/(ISSN)1365-2168 http://doi.org/10.1002/(ISSN)1365-2168 http://doi.wiley.com/10.1002/%28ISSN%291365-2168 http://doi.wiley.com/10.1002/%28ISSN%291365-2168

Heit JA , Spencer FA , White RH . The epidemiology of venous thromboembolism . J Thromb Thrombolysis 2016 ; 41 ( 1 ): 3 - 14 . doi: 10.1007/s11239-015-1311-6 10.1007/s11239-015-1311-6 . DOI: 10.1007/s11239-015-1311-6 http://doi.org/10.1007/s11239-015-1311-6 http://link.springer.com/10.1007/s11239-015-1311-6 http://link.springer.com/10.1007/s11239-015-1311-6

Liao S , Woulfe T , Hyder S , et al . Incidence of venous thromboembolism in different ethnic groups: a regional direct comparison study . J Thromb Haemost 2014 ; 12 ( 2 ): 214 - 9 . doi: 10.1111/jth.12464 10.1111/jth.12464 . DOI: 10.1111/jth.12464 http://doi.org/10.1111/jth.12464 http://doi.wiley.com/10.1111/jth.12464 http://doi.wiley.com/10.1111/jth.12464

Sanchis-Gomar F , Perez-Quilis C , Leischik R , et al . Epidemiology of coronary heart disease and acute coronary syndrome . Ann Transl Med 2016 ; 4 ( 13 ): 256 . doi: 10.21037/atm.2016.06.33 10.21037/atm.2016.06.33 . DOI: 10.21037/atm.2016.06.33 http://doi.org/10.21037/atm.2016.06.33 http://atm.amegroups.com/index http://atm.amegroups.com/index

Sui H , Chen WW , . Interpretation of report on cardiovascular diseases in China ( 2015) . Chin J Cardiovasc Med 2016 ; 21 ( 4 ): 259 - 61 . Chinese. doi: 10.3969/j.issn.1007-5410.2016.04.001 10.3969/j.issn.1007-5410.2016.04.001 .

. Emphasizing the diagnosis and treatment of pulmonary thromboembolism concurrent with coronary heart disease . Chin J Cardiovasc Med 2008 ; 18 ( 3 ): 167 - 70 . Chinese. doi: 10.3969/j.issn.1007-5410.2008.03.003 10.3969/j.issn.1007-5410.2008.03.003 .

Zhang XF , Zhu GF , Liu S . Clinical characteristics and intervention of pulmonary thromboembolism patients with coronary atherosclerotic heart disease . Chin General Practice 2011 ; 14 ( 31 ): 3577 - 9 . Chinese. doi: 10.3969/j.issn.1007-9572.2011.31.013 10.3969/j.issn.1007-9572.2011.31.013 . DOI: 10.1007/s10570-010-9464-0 http://doi.org/10.1007/s10570-010-9464-0 http://en.cnki.com.cn/Article_en/CJFDTOTAL-QKYX201131016.htm http://en.cnki.com.cn/Article_en/CJFDTOTAL-QKYX201131016.htm

Braekkan SK , Mathiesen EB , Njølstad I , et al . Family history of myocardial infarction is an independent risk factor for venous thromboembolism: the Tromsø study . J Thromb Haemost 2008 ; 6 ( 11 ): 1851 - 7 . doi: 10.1111/j.1538-7836.2008.03102.x 10.1111/j.1538-7836.2008.03102.x . DOI: 10.1111/j.1538-7836.2008.03102.x http://doi.org/10.1111/j.1538-7836.2008.03102.x http://blackwell-synergy.com/doi/abs/10.1111/jth.2008.6.issue-11 http://blackwell-synergy.com/doi/abs/10.1111/jth.2008.6.issue-11

Bruzelius M , Strawbridge RJ , Trégouët DA , et al . Influence of coronary artery disease-associated genetic variants on risk of venous thromboembolism . Thromb Res 2014 ; 134 ( 2 ): 426 - 32 . doi: 10.1016/j.thromres.2014.03.054 10.1016/j.thromres.2014.03.054 . DOI: 10.1016/j.thromres.2014.03.054 http://doi.org/10.1016/j.thromres.2014.03.054 http://linkinghub.elsevier.com/retrieve/pii/S0049384814001844 http://linkinghub.elsevier.com/retrieve/pii/S0049384814001844

Franchini M , Mannucci PM . Venous and arterial thrombosis: different sides of the same coin? Eur J Intern Med 2008 ; 19 ( 7 ): 476 - 81 . doi: 10.1016/j.ejim.2007.10.019 10.1016/j.ejim.2007.10.019 . DOI: 10.1016/j.ejim.2007.10.019 http://doi.org/10.1016/j.ejim.2007.10.019 http://linkinghub.elsevier.com/retrieve/pii/S0953620508000496 http://linkinghub.elsevier.com/retrieve/pii/S0953620508000496

Mi Y , Yan S , Lu Y , et al . Venous thromboembolism has the same risk factors as atherosclerosis: A Prisma compliant systemic review and meta-analysis . Medicine (Baltimore) 2016 ; 95 ( 32 ): e4495 . doi: 10.1097/MD.0000000000004495 10.1097/MD.0000000000004495 . DOI: 10.1097/MD.0000000000004495 http://doi.org/10.1097/MD.0000000000004495 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00005792-201608090-00032 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00005792-201608090-00032

Lijfering WM , Flinterman LE , Vandenbroucke JP , et al . Relationship between venous and arterial thrombosis: a review of the literature from a causal perspective . Semin Thromb Hemost 2011 ; 37 ( 8 ): 885 - 96 . doi: 10.1055/s-0031-1297367 10.1055/s-0031-1297367 . DOI: 10.1055/s-0031-1297367 http://doi.org/10.1055/s-0031-1297367 http://www.thieme-connect.de/DOI/DOI?10.1055/s-0031-1297367 http://www.thieme-connect.de/DOI/DOI?10.1055/s-0031-1297367

Sørensen HT , Horvath-Puho E , Søgaard KK , et al . Arterial cardiovascular events, statins, low-dose aspirin and subsequent risk of venous thromboembolism: a population-based case-control study . J Thromb Haemost 2009 ; 7 ( 4 ): 521 - 8 . doi: 10.1111/j.1538-7836.2009.03279.x 10.1111/j.1538-7836.2009.03279.x . DOI: 10.1111/j.1538-7836.2009.03279.x http://doi.org/10.1111/j.1538-7836.2009.03279.x http://blackwell-synergy.com/doi/abs/10.1111/jth.2009.7.issue-4 http://blackwell-synergy.com/doi/abs/10.1111/jth.2009.7.issue-4

Sørensen HT , Horvath-Puho E , Pedersen L , et al . Venous thromboembolism and subsequent hospitalisation due to acute arterial cardiovascular events: a 20-year cohort study . Lancet 2007 ; 370 ( 9601 ): 1773 - 9 . doi: 10.1016/S0140-6736(07)61745-0 10.1016/S0140-6736(07)61745-0 . DOI: 10.1016/S0140-6736(07)61745-0 http://doi.org/10.1016/S0140-6736(07)61745-0 http://linkinghub.elsevier.com/retrieve/pii/S0140673607617450 http://linkinghub.elsevier.com/retrieve/pii/S0140673607617450

Committee of Experts on Rational Drug Use of the National Health and Family Planning Commission of the PRC , Chinese Pharmacists Association. Guideline of rational drug therapy for the Coronary heart disease . Chin J Fronti Med Sci 2016 ( 06 ): 19 - 108 . Chinese. doi: 10.3969/j.issn.1674-7372.2016.06.007 10.3969/j.issn.1674-7372.2016.06.007 .

Xiong CM , . Strategy of diagnosis and treatment in the coronary heart disease that concurrent with pulmonary thromboembolism . Chin J Clinicians 2013 ; 7 ( 15 ): 6788 - 91 . Chinese. doi: 10.3969/cma.j.issn.1674-0785.2013.15.002 10.3969/cma.j.issn.1674-0785.2013.15.002 .

Konstantinides SV , Torbicki A , Agnelli G , et al . Task force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC). 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism . Eur Heart J 2014 ; 35 ( 43 ): 3033 - 69 , 3069a - 3069k . doi: 10.1093/eurheartj/ehu283 10.1093/eurheartj/ehu283 . DOI: 10.1093/eurheartj/ehu283 http://doi.org/10.1093/eurheartj/ehu283 https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehu283 https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehu283

Castellucci LA , Cameron C , Le Gal G , et al . Clinical and safety outcomes associated with treatment of acute venous thromboembolism: a systematic review and meta-analysis . JAMA 2014 ; 312 ( 11 ): 1122 - 35 . doi: 10.1001/jama.2014.10538 10.1001/jama.2014.10538 . DOI: 10.1001/jama.2014.10538 http://doi.org/10.1001/jama.2014.10538 http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.10538 http://jama.jamanetwork.com/article.aspx?doi=10.1001/jama.2014.10538

van der Hulle T , Kooiman J , den Exter PL , et al . Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: a systematic review and meta-analysis . J Thromb Haemost 2014 ; 12 ( 3 ): 320 - 8 . doi: 10.1111/jth.12485 10.1111/jth.12485 . DOI: 10.1111/jth.2014.12.issue-3 http://doi.org/10.1111/jth.2014.12.issue-3 http://doi.wiley.com/10.1111/jth.2014.12.issue-3 http://doi.wiley.com/10.1111/jth.2014.12.issue-3

Ageno W , Gallus AS , Wittkowsky A , et al . Oral anticoagulant therapy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines . Chest 2012 ; 141 ( 2 Suppl ): e44S - e88S . doi: 10.1378/chest.11-2292 10.1378/chest.11-2292 . DOI: 10.1378/chest.11-2292 http://doi.org/10.1378/chest.11-2292 http://linkinghub.elsevier.com/retrieve/pii/S0012369212601196 http://linkinghub.elsevier.com/retrieve/pii/S0012369212601196

Verdecchia P , Angeli F , Aita A , et al . Why switch from warfarin to NOACs? Intern Emerg Med 2016 ; 11 ( 3 ): 289 - 93 . doi: 10.1007/s11739-016-1411-0 10.1007/s11739-016-1411-0 . DOI: 10.1007/s11739-016-1411-0 http://doi.org/10.1007/s11739-016-1411-0 http://link.springer.com/10.1007/s11739-016-1411-0 http://link.springer.com/10.1007/s11739-016-1411-0

Prandoni P , Milan M , Barbar S , et al . Incidence of arterial embolism in patients on treatment with old and new anticoagulants for venous thromboembolism . Semin Thromb Hemost 2015 ; 41 ( 2 ): 154 - 9 . doi: 10.1055/s-0035-1544162 10.1055/s-0035-1544162 . DOI: 10.1055/s-0035-1544162 http://doi.org/10.1055/s-0035-1544162 http://www.thieme-connect.de/products/ejournals/journal/10.1055/s-00000077 http://www.thieme-connect.de/products/ejournals/journal/10.1055/s-00000077

Rohla M , Weiss TW , Wojta J , et al . Double or triple antithrombotic combination therapy in patients who need anticoagulation and antiplatelet therapy in parallel . Eur Heart J Cardiovasc Pharmacother 2015 ; 1 ( 3 ): 191 - 7 . doi: 10.1093/ehjcvp/pvv014 10.1093/ehjcvp/pvv014 . DOI: 10.1093/ehjcvp/pvv014 http://doi.org/10.1093/ehjcvp/pvv014 https://academic.oup.com/ehjcvp/article-lookup/doi/10.1093/ehjcvp/pvv014 https://academic.oup.com/ehjcvp/article-lookup/doi/10.1093/ehjcvp/pvv014

Asencio LA , Huang JJ , Alpert JS . Combining antiplatelet and antithrombotic therapy (triple therapy): what are the risks and benefits? Am J Med 2014 ; 127 ( 7 ): 579 - 85 . doi: 10.1016/j.amjmed.2014.02.030 10.1016/j.amjmed.2014.02.030 . DOI: 10.1016/j.amjmed.2014.02.030 http://doi.org/10.1016/j.amjmed.2014.02.030 http://linkinghub.elsevier.com/retrieve/pii/S0002934314001958 http://linkinghub.elsevier.com/retrieve/pii/S0002934314001958

Paikin JS , Wright DS , Eikelboom JW . Effectiveness and safety of combined antiplatelet and anticoagulant therapy: a critical review of the evidence from randomized controlled trials . Blood Rev 2011 ; 25 ( 3 ): 123 - 9 . doi: 10.1016/j.blre.2011.01.007 10.1016/j.blre.2011.01.007 . DOI: 10.1016/j.blre.2011.01.007 http://doi.org/10.1016/j.blre.2011.01.007 http://linkinghub.elsevier.com/retrieve/pii/S0268960X11000087 http://linkinghub.elsevier.com/retrieve/pii/S0268960X11000087

Sanchez O , Planquette B , Meyer G . Management of massive and submassive pulmonary embolism: focus on recent randomized trials . Curr Opin Pulm Med 2014 ; 20 ( 5 ): 393 - 9 . doi: 10.1097/MCP.0000000000000089 10.1097/MCP.0000000000000089 . DOI: 10.5114/aoms.2012.32402 http://doi.org/10.5114/aoms.2012.32402 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00063198-201409000-00002 http://content.wkhealth.com/linkback/openurl?sid=WKPTLP:landingpage&an=00063198-201409000-00002

Wang C , Zhai Z , Yang Y , et al . Efficacy and safety of low dose recombinant tissue-type plasminogen activator for the treatment of acute pulmonary thromboembolism: a randomized, multicenter, controlled trial . Chest 2010 ; 137 ( 2 ): 254 - 62 . doi: 10.1378/chest.09-0765 10.1378/chest.09-0765 . DOI: 10.1378/chest.09-0765 http://doi.org/10.1378/chest.09-0765 http://linkinghub.elsevier.com/retrieve/pii/S0012369210600669 http://linkinghub.elsevier.com/retrieve/pii/S0012369210600669

Sharifi M , Bay C , Skrocki L , et al . Moderate pulmonary embolism treated with thrombolysis (from the “MOPETT” Trial) . Am J Cardiol 2013 ; 111 ( 2 ): 273 - 7 . doi: 10.1016/j.amjcard.2012.09.027 10.1016/j.amjcard.2012.09.027 . DOI: 10.1016/j.amjcard.2012.09.027 http://doi.org/10.1016/j.amjcard.2012.09.027 http://linkinghub.elsevier.com/retrieve/pii/S0002914912022059 http://linkinghub.elsevier.com/retrieve/pii/S0002914912022059

DeEugenio D , Kolman L , DeCaro M , et al . Risk of major bleeding with concomitant dual antiplatelet therapy after percutaneous coronary intervention in patients receiving long-term warfarin therapy . Pharmacotherapy 2007 ; 27 ( 5 ): 691 - 6 . doi: 10.1592/phco.27.5.691 10.1592/phco.27.5.691 . DOI: 10.1592/phco.27.5.691 http://doi.org/10.1592/phco.27.5.691 http://doi.wiley.com/10.1592/phco.27.5.691 http://doi.wiley.com/10.1592/phco.27.5.691

Saheb KJ , Deng BQ , Hu QS , et al . Triple antithrombotic therapy versus double antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients requiring chronic oral anticoagulation: a meta-analysis . Chin Med J 2013 ; 126 ( 13 ): 2536 - 42 .

Khurram Z , Chou E , Minutello R , et al . Combination therapy with aspirin, clopidogrel and warfarin following coronary stenting is associated with a significant risk of bleeding . J Invasive Cardiol 2006 ; 18 ( 4 ): 162 - 4 .

Rubboli A , Milandri M , Castelvetri C , et al . Meta-analysis of trials comparing oral anticoagulation and aspirin versus dual antiplatelet therapy after coronary stenting. Clues for the management of patients with an indication for long-term anticoagulation undergoing coronary stenting . Cardiology 2005 ; 104 ( 2 ): 101 - 6 . doi: 10.1159/000086918 10.1159/000086918 . DOI: 10.1159/000086918 http://doi.org/10.1159/000086918 https://www.karger.com/Article/FullText/86918 https://www.karger.com/Article/FullText/86918

Gibson CM , Mehran R , Bode C , et al . Prevention of bleeding in patients with atrial fibrillation undergoing PCI . N Engl J Med 2016 ; 375 ( 25 ): 2423 - 34 . doi: 10.1056/NEJMoa1611594 10.1056/NEJMoa1611594 . DOI: 10.1056/NEJMoa1611594 http://doi.org/10.1056/NEJMoa1611594 http://www.nejm.org/doi/10.1056/NEJMoa1611594 http://www.nejm.org/doi/10.1056/NEJMoa1611594

Mekaj YH , Daci FT , Mekaj AY . New insights into the mechanisms of action of aspirin and its use in the prevention and treatment of arterial and venous thromboembolism . Ther Clin Risk Manag 2015 ; 11 : 1449 - 56 . doi: 10.2147/TCRM.S92222 10.2147/TCRM.S92222 . DOI: 10.2147/TCRM.S92222 http://doi.org/10.2147/TCRM.S92222 http://europepmc.org/abstract/MED/26445544 http://europepmc.org/abstract/MED/26445544

Becattini C , Agnelli G , Schenone A , et al . Aspirin for preventing the recurrence of venous thromboembolism . N Engl J Med 2012 ; 366 ( 21 ): 1959 - 67 . doi: 10.1056/NEJMoa1114238 10.1056/NEJMoa1114238 . DOI: 10.1056/NEJMoa1114238 http://doi.org/10.1056/NEJMoa1114238 http://www.nejm.org/doi/abs/10.1056/NEJMoa1114238 http://www.nejm.org/doi/abs/10.1056/NEJMoa1114238

Brighton TA , Eikelboom JW , Mann K , et al . Low-dose aspirin for preventing recurrent venous thromboembolism . N Engl J Med 2012 ; 367 ( 21 ): 1979 - 87 . doi: 10.1056/NEJMoa1210384 10.1056/NEJMoa1210384 . DOI: 10.1056/NEJMoa1210384 http://doi.org/10.1056/NEJMoa1210384 http://www.nejm.org/doi/abs/10.1056/NEJMoa1210384 http://www.nejm.org/doi/abs/10.1056/NEJMoa1210384

Kuijer PM , Hutten BA , Prins MH , et al . Prediction of the risk of bleeding during anticoagulant treatment for venous thromboembolism . Arch Intern Med 1999 ; 159 ( 5 ): 457 - 60 . doi: 10.1001/archinte.159.5.457 10.1001/archinte.159.5.457 . DOI: 10.1001/archinte.159.5.457 http://doi.org/10.1001/archinte.159.5.457 http://archinte.jamanetwork.com/article.aspx?doi=10.1001/archinte.159.5.457 http://archinte.jamanetwork.com/article.aspx?doi=10.1001/archinte.159.5.457

Ruíz-Giménez N , Suárez C , González R , et al . Predictive variables for major bleeding events in patients presenting with documented acute venous thromboembolism. Findings from the RIETE Registry . Thromb Haemost 2008 ; 100 ( 1 ): 26 - 31 . doi: 10.1160/TH08-03-0193 10.1160/TH08-03-0193 . DOI: 10.1160/TH08-03-0193 http://doi.org/10.1160/TH08-03-0193 http://www.thieme-connect.de/DOI/DOI?10.1160/TH08-03-0193 http://www.thieme-connect.de/DOI/DOI?10.1160/TH08-03-0193

Pisters R , Lane DA , Nieuwlaat R , et al . A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: the Euro Heart Survey . Chest 2010 ; 138 ( 5 ): 1093 - 100 . doi: 10.1378/chest.10-0134 10.1378/chest.10-0134 . DOI: 10.1378/chest.10-0134 http://doi.org/10.1378/chest.10-0134 http://linkinghub.elsevier.com/retrieve/pii/S0012369210605855 http://linkinghub.elsevier.com/retrieve/pii/S0012369210605855

Fang MC , Go AS , Chang Y , et al . A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA (Anticoagulation and Risk Factors in Atrial Fibrillation) Study . J Am Coll Cardiol 2011 ; 58 ( 4 ): 395 - 401 . doi: 10.1016/j.jacc.2011.03.031 10.1016/j.jacc.2011.03.031 . DOI: 10.1016/j.jacc.2011.03.031 http://doi.org/10.1016/j.jacc.2011.03.031 http://linkinghub.elsevier.com/retrieve/pii/S0735109711015713 http://linkinghub.elsevier.com/retrieve/pii/S0735109711015713

Gage BF , Yan Y , Milligan PE , et al . Clinical classification schemes for predicting hemorrhage: results from the National Registry of Atrial Fibrillation (NRAF) . Am Heart J 2006 ; 151 ( 3 ): 713 - 9 . doi: 10.1016/j.ahj.2005.04.017 10.1016/j.ahj.2005.04.017 . DOI: 10.1016/j.ahj.2005.04.017 http://doi.org/10.1016/j.ahj.2005.04.017 http://linkinghub.elsevier.com/retrieve/pii/S0002870305004369 http://linkinghub.elsevier.com/retrieve/pii/S0002870305004369

Kearon C , Akl EA , Ornelas J , et al . Antithrombotic therapy for VTE disease: CHEST guideline and expert panel report . Chest 2016 ; 149 ( 2 ): 315 - 52 . doi: 10.1016/j.chest.2015.11.026 10.1016/j.chest.2015.11.026 . DOI: 10.1016/j.chest.2015.11.026 http://doi.org/10.1016/j.chest.2015.11.026 http://linkinghub.elsevier.com/retrieve/pii/S0012369215003359 http://linkinghub.elsevier.com/retrieve/pii/S0012369215003359

Di Nisio M , Ageno W , Rutjes AW , et al . Risk of major bleeding in patients with venous thromboembolism treated with rivaroxaban or with heparin and vitamin K antagonists . Thromb Haemost 2016 ; 115 ( 2 ): 424 - 32 . doi: 10.1160/TH15-06-0474 10.1160/TH15-06-0474 . DOI: 10.1160/th15-06-0474 http://doi.org/10.1160/th15-06-0474 http://www.thieme-connect.de/DOI/DOI?10.1160/th15-06-0474 http://www.thieme-connect.de/DOI/DOI?10.1160/th15-06-0474

Riva N , Bellesini M , Di Minno MN , et al . Poor predictive value of contemporary bleeding risk scores during long-term treatment of venous thromboembolism. A multicentre retrospective cohort study . Thromb Haemost 2014 ; 112 ( 3 ): 511 - 21 . doi: 10.1160/TH14-01-0081 10.1160/TH14-01-0081 . DOI: 10.1160/TH14-01-0081 http://doi.org/10.1160/TH14-01-0081 http://www.thieme-connect.de/DOI/DOI?10.1160/TH14-01-0081 http://www.thieme-connect.de/DOI/DOI?10.1160/TH14-01-0081

Klok FA , Hosel V , Clemens A , et al . Prediction of bleeding events in patients with venous thromboembolism on stable anticoagulation treatment . Eur Respir J 2016 ; 48 ( 5 ): 1369 - 76 . doi: 10.1183/13993003. 00280-2016 10.1183/13993003. 00280-2016 . DOI: 10.1183/13993003.00280-2016 http://doi.org/10.1183/13993003.00280-2016 http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00280-2016 http://erj.ersjournals.com/lookup/doi/10.1183/13993003.00280-2016

Loewen P , Dahri K . Risk of bleeding with oral anticoagulants: an updated systematic review and performance analysis of clinical prediction rules . Ann Hematol 2011 ; 90 ( 10 ): 1191 - 200 . doi: 10.1007/s00277-011-1267-3 10.1007/s00277-011-1267-3 . DOI: 10.1007/s00277-011-1267-3 http://doi.org/10.1007/s00277-011-1267-3 http://link.springer.com/10.1007/s00277-011-1267-3 http://link.springer.com/10.1007/s00277-011-1267-3

Apostolakis S , Lane DA , Guo Y , et al . Performance of the HEMORR(2)HAGES, ATRIA, and HAS-BLED bleeding risk-prediction scores in patients with atrial fibrillation undergoing anticoagulation: the AMADEUS (evaluating the use of SR34006 compared to warfarin or acenocoumarol in patients with atrial fibrillation) study . J Am Coll Cardiol 2012 ; 60 ( 9 ): 861 - 7 . doi: 10.1016/j.jacc.2012.06.019 10.1016/j.jacc.2012.06.019 . DOI: 10.1016/j.jacc.2012.06.019 http://doi.org/10.1016/j.jacc.2012.06.019 http://linkinghub.elsevier.com/retrieve/pii/S0735109712023686 http://linkinghub.elsevier.com/retrieve/pii/S0735109712023686

Zhu W , He W , Guo L , et al . The HAS-BLED Score for predicting major bleeding risk in anticoagulated patients with atrial fibrillation: a systematic review and meta-analysis . Clin Cardiol 2015 ; 38 ( 9 ): 555 - 61 . doi: 10.1002/clc.22435 10.1002/clc.22435 . DOI: 10.1002/clc.22435 http://doi.org/10.1002/clc.22435 http://doi.wiley.com/10.1002/clc.22435 http://doi.wiley.com/10.1002/clc.22435

Esteve-Pastor MA , Garcia-Fernandez A , Macias M , et al . Is the ORBIT bleeding risk score superior to the HAS-BLED score in anticoagulated atrial fibrillation patients? Circ J 2016 ; 80 ( 10 ): 2102 - 8 . doi: 10.1253/circj.CJ-16-0471 10.1253/circj.CJ-16-0471 . DOI: 10.1253/circj.CJ-16-0471 http://doi.org/10.1253/circj.CJ-16-0471 https://www.jstage.jst.go.jp/article/circj/80/10/80_CJ-16-0471/_article https://www.jstage.jst.go.jp/article/circj/80/10/80_CJ-16-0471/_article

Senoo K , Proietti M , Lane DA , et al . Evaluation of the HAS-BLED, ATRIA, and ORBIT bleeding risk scores in patients with atrial fibrillation taking warfarin . Am J Med 2016 ; 129 ( 6 ): 600 - 7 . doi: 10.1016/j.amjmed.2015.10.001 10.1016/j.amjmed.2015.10.001 . DOI: 10.1016/j.amjmed.2015.10.001 http://doi.org/10.1016/j.amjmed.2015.10.001 http://linkinghub.elsevier.com/retrieve/pii/S0002934315009262 http://linkinghub.elsevier.com/retrieve/pii/S0002934315009262

Costa F , Tijssen JG , Ariotti S , et al . Incremental value of the CRUSADE, ACUITY, HAS-BLED risk scores for the prediction of hemorrhagic events after coronary stent implantation in patients undergoing long or short duration of dual antiplatelet therapy . J Am Heart Assoc 2015 ; 4 ( 12 ): pii: e002524 . doi: 10.1161/JAHA.115.002524 10.1161/JAHA.115.002524 .

浏览量

3139

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

关联资源

暂无数据