餐厨油烟引起肺癌的毒性机制

王春燕; 刘立芳; 刘晓丽; 陈文俊; 何国平

doi:10.24920/J1001-9294.2017.026

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餐厨油烟引起肺癌的毒性机制

中国医学科学杂志（英文版） 2017年32卷第3期页码：193-197

Review | Updated：2024-04-10

- 餐厨油烟引起肺癌的毒性机制
- Affiliations：
  
  1. 1Xiangya Nursing School, Central South University, Changsha 410013, China
  2. 2Organ Transplant Department, Third Xiangya Hospital, Central South University, Changsha 410013, China
- Author bio：
  
  * Corresponding author E-mail: Heguopping@csu.edu.cn
- Funds：
  
  △Supported by the Development Project of Community Health Nursing Innovative Practice Model of China (CMB08883).
- DOI：10.24920/J1001-9294.2017.026
  中图分类号：
- 收稿日期：2016-08-30，
  
  纸质出版日期：2017-09
- Accepted：
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王春燕, 刘立芳, 刘晓丽, 等. 餐厨油烟引起肺癌的毒性机制[J]. 中国医学科学杂志（英文版）, 2017,32(3):193-197.

Wang Chun-yan, Liu Li-fang, Liu Xiao-li, et al. Mechanisms of Lung Cancer Caused By Cooking Fumes Exposure: A Minor Review^△[J]. Chinese medical sciences journal, 2017, 32(3): 193-197.
王春燕, 刘立芳, 刘晓丽, 等. 餐厨油烟引起肺癌的毒性机制[J]. 中国医学科学杂志（英文版）, 2017,32(3):193-197. DOI： 10.24920/J1001-9294.2017.026.

Wang Chun-yan, Liu Li-fang, Liu Xiao-li, et al. Mechanisms of Lung Cancer Caused By Cooking Fumes Exposure: A Minor Review^△[J]. Chinese medical sciences journal, 2017, 32(3): 193-197. DOI： 10.24920/J1001-9294.2017.026.

摘要

餐厨油烟是多种毒性物质的混合体，例如醛类、杂环胺、多环芳烃、脂肪气溶胶和颗粒物。研究表明：很多类疾病与餐厨油烟暴露有关，其中以餐厨油烟引起的肺癌报道最多。分子和生化研究表明：餐厨油烟引起肺癌的途径主要有基因损伤、形成活性氧、妨碍相关蛋白功能、甚至直接导致细胞死亡。然而，有关餐厨油烟引起肺癌机制研究的综述性文章较少。阐明餐厨油烟引起肺癌的机理能够给相关肺癌的防治提供新途径，并且能够为餐厨油烟的毒理学研究提供基础。因此本文主要对餐厨油烟引起肺癌的机制进行了总结及讨论。

Abstract

Cooking fumes (CFs) are mixtures of many toxic components

such as aldehydes

heterocyclic amines

polycyclic aromatic hydrocarbons

fat aerosols and particulate matters. CFs exposure has been proven to be associated with many diseases. Lung cancer takes the leading place among the diseases being reported caused by CFs exposure. Molecular and biochemical studies have found that CFs exposure may lead to lung cancer by gene damage

formation of reactive oxygen species

blockage of related proteins’ function

and even cell death. However

reviews about the mechanisms of how CFs exposure leads to lung cancer are still lacking. Elucidation of the mechanisms of lung cancer caused by CFs exposure may provide a new insight into the prevention of lung cancer caused by CFs exposure

as well as laying the foundation for the toxicity study of CFs. In this minor review

the mechanisms of how CFs exposure leads to lung cancer were summarized and discussed.

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references

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