杓型与非杓型高血压患者的血浆干细胞因子及其受体表达水平研究

钟海兰; 徐崇利; 陈广胜; 陈秀梅

doi:10.24920/J1001-9294.2017.035

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杓型与非杓型高血压患者的血浆干细胞因子及其受体表达水平研究

中国医学科学杂志(英文版) 2017年32卷第4期页码：232-238

ORIGINAL ARTICLE | Updated：2024-04-10

- 杓型与非杓型高血压患者的血浆干细胞因子及其受体表达水平研究
- Affiliations：
  
  1. 1Department of Cardiology, Jiangning Hospital of Nanjing, Nanjing 211100, China
  2. 2Department of Cardiology, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China
- Author bio：
  
  * Corresponding author Tel: 86-25-52281148, E-mail: hlzhong750105@126.com
- Funds：
- DOI：10.24920/J1001-9294.2017.035
  中图分类号：
- 收稿日期：2017-02-26，
  
  网络出版日期：2017-12-30，
  
  纸质出版日期：2017-12
- Accepted：
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钟海兰, 徐崇利, 陈广胜, 等. 杓型与非杓型高血压患者的血浆干细胞因子及其受体表达水平研究[J]. 中国医学科学杂志(英文版), 2017,32(4):232-238.

Zhong Hailan, Xu Chongli, Chen Guangsheng, et al. Plasma SCF/c-kit Levels in Patients with Dipper and Non-Dipper Hypertension[J]. Chinese medical sciences journal, 2017, 32(4): 232-238.
钟海兰, 徐崇利, 陈广胜, 等. 杓型与非杓型高血压患者的血浆干细胞因子及其受体表达水平研究[J]. 中国医学科学杂志(英文版), 2017,32(4):232-238. DOI： 10.24920/J1001-9294.2017.035.

Zhong Hailan, Xu Chongli, Chen Guangsheng, et al. Plasma SCF/c-kit Levels in Patients with Dipper and Non-Dipper Hypertension[J]. Chinese medical sciences journal, 2017, 32(4): 232-238. DOI： 10.24920/J1001-9294.2017.035.

摘要

目的

探讨杓型与非杓型高血压类型与患者外周血浆中干细胞因子（SCF）及其受体(c-kit)表达水平的关系。

方法

2009-2012年

收集247例江宁地区的新确诊高血压患者作为此次横断面研究的对象。所有患者进行动态血压监测

并且按照动态血压模式被分为两组

非杓型高血压组和杓型高血压组。通过酶联免疫吸附方法检测每位患者外周血浆中的SCF/c-kit

肿瘤坏死因子(TNF-α)及白细胞介素6(IL-6)的表达水平

并测得每位患者血脂、血糖指标。比较杓形和非杓形高血压患者的SCF/c-kit水平差异

并分析其与24小时平均收缩压、24小时平均舒张压、TNF-α和IL-6的相关性。

结果

非杓型高血压患者外周血浆中SCF表达水平明显高于杓型高血压患者(907.1 ± 52. vs. 778.7 ± 44.6

; P

0.01)

非杓型高血压患者外周血浆中c-kit表达水平也明显高于杓型高血压患者(13.2 ± 1.7 vs. 9.57 ± 1.4;

0.01)。线性回归分析表明

SCF及其受体c-kit表达与24小时平均收缩压、24小时平均舒张压、TNF-α及IL-6水平正相关(均P

0.01)。

结论

非杓型高血压患者的外周血浆中干细胞因子及其受体表达水平明显高于杓型高血压患者

并且干细胞因子及其受体表达水平与24小时平均收缩压、24小时平均舒张压、TNF-α及IL-6正相关。

Abstract

Objective

The aim of this study was to investigate the relationship between peripheral plasma stem cell factor (SCF)/c-kit levels and the types of dipper and non-dipper hypertension in hypertensive patients.

Methods

This cross-sectional study included newly diagnosed hypertensive patients who underwent 24-hour ambulatory blood pressure monitor (ABPM) between January 2009 and 2012 in Jiangning city. Patients were divided into the dipper group and the non-dipper group according to ABPM measurements. The levels of SCF and its receptor c-kit

tumor necrosis factor-α (TNF-α) and interleukin 6 (IL-6) in peripheral blood were measured

via

enzyme-linked immunosorbent assays. The serum levels of glucose and lipid were examined as well. The levels of SCF/c-kit were compared between the dippers and the non-dippers; and their correlation with 24-hour mean systolic blood pressure (MSBP)

24-hour mean diastolic blood pressure (MDBP)

TNF-α and IL-6 were investigated using linear regression analyses statistically.

Results

A total of 247 patients with newly diagnosed hypertension were recruited into the study

including 116 non-dippers and 131 dippers. The levels of peripheral plasma SCF were higher in non-dipper group (907.1±52.7 ng/L

. 778.7±44.6 ng/L;

=2.837

0.01)

and the levels of c-kit were higher in non-dipper group too (13.2±1.7 μg/L

9.57±1.4 μg/L;

=2.831

0.01). Linear regression analysis revealed that SCF/c-kit levels were significantly positively correlated with MSBP

MDBP

plasma TNF-α

and IL-6 levels (all

0.01).

Conclusions

Peripheral plasma SCF/c-kit levels are higher in patients with non-dipper hypertension than those with dipper one

and significantly correlate with 24-hour MSBP

24-hour MDBP

serum TNF-α and IL-6 levels.

关键词

Keywords

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