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活性氧簇/钾离子通道/低氧诱导因子轴在低氧性肺动脉高压形成中的作用
- Affiliations：
1. 1Department of Ultrasound, General Hospital of the Army, Beijing 100007, China
2. 2.Medical Examination Center, General Hospital of the Army, Beijing 100007, China
3. 3Clinical Laboratory, the Xigaze Branch of Xinqiao Hospital, the Army Medical University, Xigaze, Tibet 857000, China
- Author bio：
Corresponding author Tel: 86-17710560131, E-mail:149011273@qq.com
- Funds：
DOI：10.24920/J1001-9294.2017.037
中图分类号：收稿日期：2016-10-24，
网络出版日期：2017-12-30，
纸质出版日期：2017-12
- Accepted：
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武文, 李燕, 徐敦全. 活性氧簇/钾离子通道/低氧诱导因子轴在低氧性肺动脉高压形成中的作用[J]. 中国医学科学杂志(英文版), 2017,32(4):253-259.
Wu Wen, Li Yan, Xu Dunquan. Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension[J]. Chinese medical sciences journal, 2017, 32(4): 253-259.
武文, 李燕, 徐敦全. 活性氧簇/钾离子通道/低氧诱导因子轴在低氧性肺动脉高压形成中的作用[J]. 中国医学科学杂志(英文版), 2017,32(4):253-259. DOI： 10.24920/J1001-9294.2017.037.
Wu Wen, Li Yan, Xu Dunquan. Role of ROS/Kv/HIF Axis in the Development of Hypoxia-Induced Pulmonary Hypertension[J]. Chinese medical sciences journal, 2017, 32(4): 253-259. DOI： 10.24920/J1001-9294.2017.037.
摘要
低氧性肺动脉高压是常见于慢性阻塞性病
睡眠呼吸障碍性疾病
或久居高海拔的居民所患的一种严重并发症。目前关于低氧性肺动脉高压确切的发病机制仍不完全明了。活性氧簇
低氧诱导因子和钾离子通道被认为在低氧性肺动脉高压的发生发展中起重要作用。在此我们认为“活性氧簇/钾离子通道/低氧诱导因子”轴在低氧性肺动脉高压的发生发展中可能起到触发作用。活性氧簇首先产生于低氧环境
其后影响低氧诱导因子和钾离子通道的表达
继而触发下游多条途径参与肺动脉血管收缩和血管重构的各种基因和信号因子的表达。因此
研究“活性氧簇/钾离子通道/低氧诱导因子”轴在低氧性肺动脉高压发生发展中的作用将会为揭示低氧性肺动脉高压的发生机制提供理论依据
并有助于为肺动脉高压提供潜在的治疗靶点。
Abstract
Hypoxic pulmonary hypertension (HPH) is a common complication in patients with chronic obstructive pulmonary disease (COPD)
sleep-disordered breathing
or dwellers in high altitude. The exact mechanisms underlying the development of HPH still remain unclear. Reactive oxygen species (ROS)
hypoxia inducible factors (HIF)
and potassium channels (K
V
) are believed as the main factors during the development of HPH. We propose that the “ROS/Kv/HIF axis” may play an important initiating role in the development of HPH. Being formed under a hypoxic condition
ROS affects the expression and function of HIFs or K
V
and consequently triggers multiple downstream signaling pathways and genes expression that participate in promoting pulmonary vasoconstriction and arterial remodeling. Thus
further study determining the initiating role of “ROS/Kv/HIF axis” in the development of HPH could provide theoretic evidences to better understand the underlying mechanisms of HPH
and help identify new potential targets in the treatment of HPH.
关键词
Keywords
references
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