“Reporting on the advancements in China's modern palliative care, this study introduces its research progress in the field of clinical medicine terminology. Expert consensus established the definitions of "palliative care" and "hospice care" tailored to the Chinese context, which provides a foundation for discipline development, clinical practice, and public communication.”
“In the field of attention assessment, researchers have developed the Multi-dimensional Attention Rating Scale (MARS), a self-report tool that evaluates six-dimension attention levels. The MARS, based on Classical Test Theory, demonstrated high reliability and validity, offering a new tool for assessing multi-dimensional attention impairments in various mental disorders.”
“Reporting on the latest medical advancements, a study at Peking Union Medical College Hospital reveals that postoperative pneumonia is the sole predictor of prolonged hospital stays in elderly patients after hip fracture surgery. The research, which analyzed data from 155 patients aged 90 and above, found no link between anesthesia type or airway management methods and extended postoperative length of stay or pneumonia occurrence. This insight underscores the importance of preoperative respiratory conditions and systemic inflammation in postoperative recovery.”
“In the field of medical technology management, a bibliometric analysis reveals a steady increase in research output and a shift in focus from basic medical needs to emergency response and medical information security. The United States, Italy, and the United Kingdom are the main contributors, with the United States leading in both publication volume and academic impact. Future research should emphasize interdisciplinary and international cooperation.”
王流芳, 黄玉妮, 王思惟, 秦小平, 胡致远, 王炳龙, 胡志民
2025, 40(2): 120-131. DOI: 10.24920/004456
Abstract:目的采用文献计量方法分析医疗科技管理(medical technology management,MTM)研究领域相关文献,探讨此领域潜在关键词、研究集群、合作情况及研究趋势,为研究者、政策制定者和医院管理者提供有价值的信息。方法在Web of Science核心数据库中,通过检索文献标题、摘要及关键词,结合系统推荐术语,筛选MTM相关文献。最终纳入发表于1974年至2022年的181篇文献。采用VOSviewer软件分析研究产出,总被引次数、平均被引次数和H指数等质量指标,文献耦合、共同作者以及关键词共现。结果MTM领域的文献数量总体上呈逐年稳步增长。研究重点已从满足基本医疗需求转向优先关注应急响应和医疗信息安全。美国、意大利和英国是主要的研究贡献国家,其中美国在发文量(60篇)和学术影响力(H指数 = 21)均居首位。来自英国和美国的作者在跨国合作方面处于领先地位。按跨机构作者之间的总链接强度排名,前五名的机构主要来自加拿大和西班牙。结论在过去30年(1993~2022年)中,MTM领域发文数量呈稳定增多。研究重点的转移促使人们更加重视保护患者隐私和确保医疗数据的安全。未来的研究应着重加强跨学科和专业间的协作,以及推动国际合作和知识的开放共享。
“Reporting on the latest research, a two-sample Mendelian randomization study has shed light on the causal link between cytoplasmic unactivated mineralocorticoid receptor (MR) levels and the development of tubulointerstitial nephritis (TIN), as well as its impact on dyslipidemia in diabetic kidney disease patients. Expert-led research established a significant causal association between MR levels and decreased TIN risk, and a potential link with lower LDL-C levels, providing a new direction for research into MR-antagonists to mitigate renal damage and lipid metabolism-related complications.”
何敏, 杨晓萍
2025, 40(2): 132-143. DOI: 10.24920/004447
Abstract:目的探究胞质盐皮质激素受体(mineralocorticoid receptor,MR)水平与肾小管间质性肾炎(tubulointerstitial nephritis,TIN)发展之间的因果关系,并评估MR对糖尿病肾病患者血脂异常,特别是继发性高脂血症的影响。方法我们利用全基因组关联研究(genome-wide association study,GWAS)汇总数据,采用双样本孟德尔随机化分析方法,以MR水平相关的遗传变异为工具变量,探讨MR对TIN及血脂等结局变量的因果效应。血脂指标包括低密度脂蛋白胆固醇(low-density lipoprotein cholesterol,LDL-C)、甘油三酯和高密度脂蛋白胆固醇。采用两步孟德尔随机化分析评估TIN在MR和血脂代谢之间的中介效应。孟德尔随机化分析主要采用逆方差加权法,以敏感性分析、孟德尔随机化-Egger分析和加权中位数法作为补充。结果胞质非活化MR水平与TIN风险降低呈显著因果关联(OR = 0.8598,95% CI [0.7775~0.9508],P <0.001)。尽管我们未发现MR水平与继发性高脂血症呈显著因果关系,但胞质非活化MR水平可能与LDL-C水平降低存在潜在关联(OR = 0.9901,95% CI [0.9821~0.9983],P = 0.018)。此外,TIN与继发性高脂血症(OR = 1.0016,95% CI [1.0002~1.0029],P = 0.020)以及LDL-C水平升高(OR = 1.0111,95% CI [1.0024~1.0199],P = 0.012)均存在因果关联,TIN与LDL-C的关联在欧洲男性人群中更为明显(OR = 1.0230,95% CI [1.0103~1.0358],P < 0.001)。反向孟德尔随机化分析显示:TIN与甘油三酯(OR = 0.7027,95% CI [0.6189~0.7978],P < 0.001)、高密度脂蛋白胆固醇(OR = 1.1247,95% CI [1.0019~1.2626],P = 0.046)以及LDL-C(OR = 0.8423,95% CI [0.7220~0.9827],P = 0.029)均存在显著因果关系。TIN在MR与LDL-C水平之间的因果链中起中介作用,中介效应占比达16.7%。结论MR在TIN及脂质代谢紊乱的进展中发挥重要作用。这一结果提示以非奈利酮为代表的MR拮抗剂可望缓解肾脏损伤和预防脂质代谢相关并发症。
“Reporting on the latest research in the medical device procurement and sales sector, the article introduces its research progress in the field of anti-commercial bribery. Expert xx established the preventive regulatory framework, which provides solutions to effectively reduce commercial bribery risks and prevent illegal and non-compliant conduct.”