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1990 Year 2 Issue
- Abstract：<正> Recently a novel diterpene triepoxide-16-hydroxytriptolide-was discovered by researchers in theInstitute of Dematology of CAMS.This discovery followed a report of the active anti-inflammatory,im-munosuppressive and antifertility effects of another 5 monomers (T2,T3,T4,T6T28)isolated fromTripterygium wilfordii.5|15|0Updated：2024-04-10
- Abstract：<正> A least.squares refinement procedure has been proposed for resolving enantiomorphous am-biguity of noncentrosymmetric structures containing heavy atoms in a centrosymmetric ar-rangement.During the least-squares refinement of a pseudo-centrosymmetric image containingboth enantiomorphs,the temperature factors of atoms in one enantiomorph shift in the samedirection,while those of the other shift in the opposite direction.Accordingly the truestructure can be distinguished easily from its enantiomorph.Tests on four unknown struc-tures have shown that the method is very powerful.5|5|0Updated：2024-04-10
- Abstract：<正> Human sperm membrane antigens extracted by deoxycholate （DOC） were used to immunizeBALB/c mice.Hybrid cell lines secreting sperm-specific monoclonal antibodies were generatedby cell fusion in a semi-solid medium and screened by indirect immunofluorescent assay usinglive and methanol-fixed sperm.Out of 850 hybrid clones from cell fusion,28 were shownto secrete sperm-specific antibodies which reacted with the acrosome,equatorial segment,whole surface plasma membrane or tail of spermatozoa.Finally,seven hybrid cell lineswere established and shown to secrete monoclonal antibodies which had no cross-reactivitywith arty human tissues other than testis and sperm.The majority were also shown toinhibit fertilization of mouse oocytes in vitro and human sperm penetration of zona-freehamster ova.Western blot analysis revealed that some of these antibodies reacted withsperm membrane antigens of distinct molecular size.6|10|0Updated：2024-04-10
- Abstract：<正> A human B cell line （3D5） that responds specifically to B cell growth factor （BCGF） hasbeen developed by a sequence of Staphylococcus aureus Cowen I activation,EB virus im-mortalization,and cloning.Proliferative response to PHA-stimulated T cell supernatant（PHA-T-Sup） and nonresponsiveness to rIL-2 stimulation were factors used to screen positivecells.Phenotype analysis with a flow cytometer indicated that:1) 3D5 is a B cell line:100% of the cells were positive for B1 marker and 59% were positive for sIg,while T3and Mo 1 were negative:2) 3D5 is an activated B cell line:both Tac and 4F2 markersof activated （but not of resting） B cells were 100% positive:3) 3D5 expresses high molecularweight BCGF （HMW-BCGF） receptor-associated epitope BA5.3D5 cells proliferated inresponse to cpBCGF stimulation in a dose-dependent manner.HMW-BCGF also induced3D5 cells to proliferate.Interestingly.no proliferation could be detected in the presenceof rIL-2,rIL-4,or rIFN-r.The data show that 3D5 cells are specifically BCGF-responsiveB cells.Using 3D5 cells as target,BCGF activity was detected in crude BCGF preparationsedimented by 85% （NH4）2SO4 and chromatographed in a DEAE-Sephadex A-25 column fromPHA-T-Sup.T24 cell supernatant with B cell differentiation factor （BCDF） activity couldnot induce 3D5 cells to differentiate into immunoglobulin-secreting cells.4|7|0Updated：2024-04-10
- Abstract：<正> In recent years.diagnostic imaging techniques,especially ultrasonography （US） and CTscanning,have been widely adopted in clinical practice,making early accurate diagnosisof renal tumors possible.A total of 452 cases of renal tumors have been admitted to theinstitute since 1951,of which 220 were seen from 1951 to 1979 and 232 in the past 9years （1980-1988）.The frequency of renal parenchymal tumors was obviously higher in thelatter group,including asymptomatic renal carcinoma in 20.2% and hamartoma in 38.1%.All these were discovered on routine physical check-up by ultrasonography and/or CTscanning and would otherwise have gone undiagnosed on conventional urography.Ultra-sonography and CT can also reveal the nature and the extent of the tumor.The idea that“a renal tumor should be considered malignant unless pathologically proven otherwise”isno longer valid.However,general manifestations of renal carcinoma,such as elevatederythrocyte sedimentation rate （ESR）,hypertension,malaise,anemia,fever and hypercalcemia,still deserve proper attention.We suggest that ultrasonography of both kidneys should bemandatory in routine physical check-up,as far as the urinary system is concerned,in orderto discover asymptomatic renal tumors.4|3|0Updated：2024-04-10
- Abstract：<正> Thirty-one multiple myeloma patients were classified chiefly by heavy and light chain detec-tion of myeloma protein （M protein）.The results were as follows:19 out of the 31 casesbelonged to the IgG class,including the following subclasses—IgG1-λ.7;IgG1-k.5;IgG3-λ,1;IgG3-k,2;double M myeoma,2 （IgG3-λ+IgG2-k,IgG1-λ+IgG4-λ）;IgG-λ,1;andIgG1-k 1.Seven cases were light chain diseases,of which 4 belonged to λ type.2 were k.and one was a double light chain disease.Five cases belonged to the IgA class （IgA-λ,3;IgA-k,2）.We found no correlation between electrophoretic mobility and the antigenicity ofM protein even within subclasses,and the highly concentrated BJP in urine had a tendencyto form light chain polymers,possibly along different polymerization pathways.4|7|1Updated：2024-04-10
- Abstract：<正> Sixty-six patients with advanced adenocarcinoma of the cardia underwent total gastrectomybetween 1978 and 1986.The operative morbidity rate was 7.5% and the hospital mortalityrate （1 month） was 1.5%.The postoperative 1,3,4,and 5 year survival rates were 69%.50.7%,20% and 13.8% respectively.The quality of life after surgery was improved.Patho-logical type,lymph node metastasis,completeness of resectionand postoperative chemotherapywere the main factors influencing postoperative survival time.Indications for total gastrec-tomy and the advantages of transthoracic total gastrectomy are discussed.4|6|0Updated：2024-04-10
- Abstract：<正> Fifteen cases,27 hips,of idiopathic necrosis of the femoral head （INFH） were included iour series.The role of radiography,isotopic bone scanning,intraosseous pressure measure-ment and intraosseous venography in the diagnosis of INFH were evaluated.Radiologicalexamination could not reveal early cases,while isotopic bone scanning was more sensitive.There was an increase of intraosseous pressure in most of the diseased hips.and intraos-seous venography showed abnormalities in all examined hips.The latter two tests couldtherefore detect early INFH.Core decompression was performed in 23 hips,21 of whichwere followed for 7 to 27 months.Functional evaluation was good or excellent in 18 hips.Radiological re-examination remained unchanged in 19 hips.Postoperative intraosseouspressure measurement and intraosseous venography revealed a decrease of intraosseous pres-sure and improvement of venous drainage.Core decompression is therefore an ideal methodof treatment for early INFH.4|17|0Updated：2024-04-10
- Abstract：<正> Quantitative analysis of dendritic cells （DC’s） was carried out in tissue specimens of normalgastric mucosa （n=15）,gastric ulcer （n=19）,chronic atrophic gastritis （n=28）,and gastriccarcinoma （n=65） by ABC immunostaining with S100 protein antibody.Significant increasein DC number were observed in chronic atrophic gastritis with type Ⅲ intestinal metaplasiaand/or grade Ⅱ,Ⅲ dysplasia.The result suggests that DC’s are potentially capable opresenting neoantigens associated with malignant transformation at the precancerous stagewhen malignant morphological changes have not yet taken place.Combined with routinediagnostic methods,the serial monitoring of DC density in gastric mucosa may be usefulin the follow-up of premalignant lesions in the stomach and the diagnosis of early gastriccarcinoma.4|8|2Updated：2024-04-10
- Abstract：<正> The N-glycine constant infusion method was used to study protein turnover in normal adultsand perioperative patients.The protein turnover rate （Q）,synthetic rate （S） and catabolicrate （C） were derived according to Picou’s two-pool system model,and the“end-productaveraging technique”showed the 15N-glycine constant iufusion method to be reliable,witha reproducibility of ±5.1%.This measurement can be repeated after a short period,so itshould be useful for surgical nutrition study.Our results show the following:Q was significantly increased after operation （3.4±0.6 to 5.0±0.5 g protein/kg/d,P<0.01）,and S （2.6±0.5 to 3.7±0.6 g protein/kg/d,P<0.05）and C （2.3±0.5 to 3.9±0.5 g protein/kg/d,P<0.01） were increased as well.This suggeststhat the protein degradation rate outstripped the synthesis rate on post-operative day three（POD+3） when traditional （glutamine-free） total parenteral nutrition support was used.4|7|0Updated：2024-04-10
- Abstract：<正> Myasthenia gravis is an autoimmune disease involving the acetylcholine receptors atneuromuscular junctions.Perioperative management of patients with myasthenia gravis iscomplicated by their enhanced sensitivity to nondepolarizing neuromuscular blocking agentsand their resistance to depolarizing drugs （1）.Prolonged respiratory depression commonlyoccurs when these agents are used.Atracurium dibesilate is one of a new series of nonde-polarizing agents and is promising by virtue of its rapid degradation by‘Hoffmann elimina-tion’.leaving products with little or no muscle blocking activity.After encouraging resultswere obtained with atracurium （2-6）,we investigated the neuromuscular blocking effect ofdifferent doses of the drug （0.2 mg/kg,0.5 mg/kg） in sixteen myasthenic patients undergoingthymectomy.with continuous monitoring of neuromuscular function.4|8|0Updated：2024-04-10
- Abstract：<正> Hyperthermia （42-44℃） and photosensitizing therapy can destroy S180 tumor cells,reducemalignant ascites and prolong the survival times of mice with carcinomas.The highestcurative effect was observed when using a combination of the two treatments.Heating to44℃ has a greater destructive effect on tumor cells than has heating to 42℃.The resultsshow that this is due to a synergistic interaction between these two treatments.The fluores-cence spectrum of S180 cells was determined before and alter treatment,and the indicationwas that the synergistic effect is probably related to a new fluorescence product;the greaterthe intensity of the new fluorescence、the more marked the synergy of hyperthermia andphotosensitizing therapy.The maximum emission wavelength was 460nm （excitation wave-length 370nm）.5|6|0Updated：2024-04-10
- Abstract：<正> The differences of serum lipid and lipoprotein (LP,profiles of animals susceptible （rabbit）and nonsusceptible （Beijing duck） to atherosclerosis as well as the distribution of apolipo-protein （apo） A-I and its catabolism in vivo were studied.Eight items,i.e.total cholesterol（TC）,high density lipoprotein （HDL） cholesterol,triglyceride,percentage of a-LP and β-LP,β-LP concentration,lecithin cholesterol acyl transferase （LCAT）,and agarose and polyacryla-mide gel electrophoresis of both species were assayed before and after feeding a high fat,high cholesterol diet.Results indicate that the exogenous cholesterol consumed by Beijingducks was carried and transported by HDL,while that in rabbits was transported by lowdensity lipoprotein （LDL）.The biological half lives of apo A-I in serum and in HDL were41.11±2.4 and 42.8±1.7 h respectively.and its distribution in different organs was in theorder of liver>kidney>spleen>lung>heart>intestine>muscles>aorta.These resultsshow that the liver is the major organ for metabolizing HDL apo A-I.and the kidneyis also important.The results also imply that in Beijing ducks the cholesterol carried byHDL may be catabolized through apo A-I receptors in the liver and kidney.The differencesin cholesterol binding and in lipoprotein and apolipoprotein metabolism of the two speciesprovide important clues for the elucidation of the pathogenesis of atherosclerosis.5|17|0Updated：2024-04-10
- Abstract：<正> The West China University of MedicalSciences （WCUMS）,founded in 1910 and form-erly named West China Union University,wasdesignated as a branch of CAMS in a ceremonyheld on the 29th of November,1989.WCUMS.one of the key medical universities directed bythe Ministry of Public Health （MPH）,incor-porates eight schools,namely:Schools of BasicMedical Sciences,Medicine,Stomatology,PublicHealth,Pharmacy,Forensic Medicine,ForeignLanguages,and Social Sciences.The Universityoffers 12 special programs on medicine,medical4|7|0Updated：2024-04-10
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