Chinese Medical Sciences Journal ›› 2013, Vol. 28 ›› Issue (3): 147-151.doi: 10.1016/S1001-9294(13)60040-1
Yan-yan Chen1, Liu-bo Wang2, Hui-li Zhu1, Xiang-yang Li1, Yan-ping Zhu1, Yu-lei Yin2, Fan-zhen Lü3, Zi-li Wang1, Jie-ming Qu1, *
Yan-yan Chen1, Liu-bo Wang2, Hui-li Zhu1, Xiang-yang Li1, Yan-ping Zhu1, Yu-lei Yin2, Fan-zhen Lü3, Zi-li Wang1, Jie-ming Qu1, *
摘要:
Methods From 2008 to 2010, 208 non-small cell lung cancer patients who underwent surgery or CT-guided biopsy were recruited from Huadong Hospital, Fudan University. Immunohistochemistry staining was performed to evaluate the PD-L1 expression in both primary lung cancer cells and CD68 positive TAM. The relationship between PD-L1 expression and the clinical pathology was evaluated using χ2 test. Spearman′s rank correlations were used to determine the correlation between PD-L1 expression in tumor cells and macrophages.Results Positive PD-L1 expression in primary cancer cells was found in 136 (65.3%) patients, which were negatively correlated with lymph node metastasis (P=0.009) and smoking history (P=0.036). Besides, TAM with PD-L1 expression (found in 116 patients) was positively associated with smoking history (P=0.034), well-differentiation (P=0.029) and negative lymph node metastasis (P=0.0096). A correlation between PD-L1 expression in primary tumor cells and non-small cell lung cancer associated macrophages was found (r=0.228, P=0.021).ConclusionPD-L1, secreted from TAM, might induce cancer cells apoptosis, and decrease lymph node metastasis.