Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (3): 275-281.doi: 10.24920/003936

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  1. 1中国农业科学院农产品加工研究所,北京100091,中国
  • 收稿日期:2021-05-16 接受日期:2022-01-23 出版日期:2022-09-30 发布日期:2022-06-26
  • 通讯作者: 李子健,朱海波;

Higenamine as a Potential Pharmacologic Stress Agent in the Detection of Coronary Artery Disease

Nana Zhang1,Zijian Li2,*(),Haibo Zhu3,*()   

  1. 1Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100050, China
    2Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health, Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education, and Beijing Key Laboratory of Cardiovascular Receptors Research, Beijing 100050, China
    3State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China
  • Received:2021-05-16 Accepted:2022-01-23 Published:2022-09-30 Online:2022-06-26
  • Contact: Zijian Li,Haibo Zhu;



关键词: 去甲乌药碱, 心肌灌注显像, 负荷药物, 冠状动脉疾病


Myocardial perfusion imaging (MPI) is valuable for the diagnosis, prognosis, and management of coronary artery disease (CAD). The most commonly used pharmacologic stress agents at present are vasodilators and adrenergic agents. However, these agents have contraindications and may cause adverse effects in some patients. Thus, other stress agents feasible for more patients are required. Higenamine (HG) is a β-adrenergic receptor agonist currently approved for clinical trials as a stress agent for myocardial infarction. It also has a promising value in MPI for the detection of CAD in preclinical and clinical studies. This review summarizes the application of HG on MPI, including its mechanism of action, stress protocol, efficacy, and safety.

Key words: coronary artery disease, higenamine, myocardial perfusion imaging, stress agent

基金资助: 中国医学科学院医学与健康科技创新工程(2021-1-I2M-028)

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