Chinese Medical Sciences Journal ›› 2017, Vol. 32 ›› Issue (3): 193-197.doi: 10.24920/J1001-9294.2017.026

• 综述 • 上一篇    下一篇

餐厨油烟引起肺癌的毒性机制

王春燕1, 刘立芳2, 刘晓丽1, 陈文俊1, 何国平1,*()   

  1. 1 湘雅护理学院,中南大学,长沙 410013
    2 中南大学湘雅三医院器官移植科,长沙 410013
  • 收稿日期:2016-08-30 出版日期:2017-09-27 发布日期:2017-09-27
  • 通讯作者: 何国平 E-mail:Heguopping@csu.edu.cn

Mechanisms of Lung Cancer Caused By Cooking Fumes Exposure: A Minor Review

Wang Chun-yan1, Liu Li-fang2, Liu Xiao-li1, Chen Wen-jun1, He Guo-ping1,*()   

  1. 1 Xiangya Nursing School, Central South University, Changsha 410013, China
    2 Organ Transplant Department, Third Xiangya Hospital, Central South University, Changsha 410013, China
  • Received:2016-08-30 Published:2017-09-27 Online:2017-09-27
  • Contact: He Guo-ping E-mail:Heguopping@csu.edu.cn

摘要:

餐厨油烟是多种毒性物质的混合体,例如醛类、杂环胺、多环芳烃、脂肪气溶胶和颗粒物。研究表明:很多类疾病与餐厨油烟暴露有关,其中以餐厨油烟引起的肺癌报道最多。分子和生化研究表明:餐厨油烟引起肺癌的途径主要有基因损伤、形成活性氧、妨碍相关蛋白功能、甚至直接导致细胞死亡。然而,有关餐厨油烟引起肺癌机制研究的综述性文章较少。阐明餐厨油烟引起肺癌的机理能够给相关肺癌的防治提供新途径,并且能够为餐厨油烟的毒理学研究提供基础。因此本文主要对餐厨油烟引起肺癌的机制进行了总结及讨论。

关键词: 餐厨油烟, 肺癌, 毒性机制

Abstract:

Cooking fumes (CFs) are mixtures of many toxic components, such as aldehydes, heterocyclic amines, polycyclic aromatic hydrocarbons, fat aerosols and particulate matters. CFs exposure has been proven to be associated with many diseases. Lung cancer takes the leading place among the diseases being reported caused by CFs exposure. Molecular and biochemical studies have found that CFs exposure may lead to lung cancer by gene damage, formation of reactive oxygen species, blockage of related proteins’ function, and even cell death. However, reviews about the mechanisms of how CFs exposure leads to lung cancer are still lacking. Elucidation of the mechanisms of lung cancer caused by CFs exposure may provide a new insight into the prevention of lung cancer caused by CFs exposure, as well as laying the foundation for the toxicity study of CFs. In this minor review, the mechanisms of how CFs exposure leads to lung cancer were summarized and discussed.

Key words: cooking fumes exposure, lung cancer, toxic mechanisms

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