Chinese Medical Sciences Journal ›› 2011, Vol. 26 ›› Issue (2): 85-90.doi: 10.1016/S1001-9294(11)60025-4

• Original Article • 上一篇    下一篇

Correlation between Acute Coronary Syndrome Classification and Multi-detector CT Characterization of Plaque

Zhi-guo Wang1, Lu-yue Gai1*, Jing-jing Gai1, Ping Li1, Xia Yang1, Qin-hua Jin1, Yun-dai Chen1, Zhi-jun Sun1, and Zhi-wei Guan2   

  1. 1Department of Cardiology, 2Department of Nuclear Medicine, The General Hospital of the People's Liberation Army, Beijing 100853, China
  • 收稿日期:2011-06-24 修回日期:2011-06-24 出版日期:2011-06-24 发布日期:2011-06-24

Correlation between Acute Coronary Syndrome Classification and Multi-detector CT Characterization of Plaque

Zhi-guo Wang1, Lu-yue Gai1*, Jing-jing Gai1, Ping Li1, Xia Yang1, Qin-hua Jin1, Yun-dai Chen1, Zhi-jun Sun1, and Zhi-wei Guan2   

  1. 1Department of Cardiology, 2Department of Nuclear Medicine, The General Hospital of the People's Liberation Army, Beijing 100853, China
  • Received:2011-06-24 Revised:2011-06-24 Online:2011-06-24 Published:2011-06-24

摘要: Objective To determine if multi-detector CT (MDCT) characterization of plaque is correlatedwith the classification of acute coronary syndrome (ACS). Methods Altogether 1900patients were examined by MDCT from December 2007 to May 2009, of whom 95patients fulfilled the criteria of ACS. Those patients were divided into thediscrete plaque group ( n=61) anddiffuse plaque group ( n=34) based onthe findings in MDCT. The clinical diagnosis of ACS and CT results wereanalyzed, including segment stenosis score, segment involvement score, 3-vesselplaque score, left main score, calcification score, and remodeling index. Theincidences of major adverse cardiac events in follow-up period were alsorecorded.ResultsThe patients of the diffuse plaque groupwere older than those of the discrete plaque group ( P<0.0001). The diffuse plaque grouppresented more cases of hypertension, peripheral artery disease, diabetes, and heart failure than discrete plaque group (all P<0.05). All the 5 patients with ST-segment elevation myocardialinfarction were found in discrete plaque group. The segment stenosis score ofthe discrete plaque group was lower than that of the diffuse plaque group(5.15±3.55 vs. 14.91±5.37, P<0.001). The other four scores demonstrated significant inter-group difference as well (all P<0.05). The remodeling index of thediscrete plaque group was higher (1.12±0.16 vs.0.97±0.20, P<0.05). Follow-up data showed that major adverse cardiac eventsoccurred more frequently in diffuse plaque group than in discrete group (29.41% vs. 11.48%, P=0.0288).Conclusions Characteristics of discrete and diffuseplaques may be significantly different among different classes of ACS. Thediffuse plaque may present higher risk, correlated to higher mortality. Thediagnosis of discrete and diffuse plaques by MDCT would provide a new insightinto the prognosis and treatment of ACS.

关键词: acute coronary syndrome, coronary plaque, multi-detector CT

Abstract: Objective To determine if multi-detector CT (MDCT) characterization of plaque is correlatedwith the classification of acute coronary syndrome (ACS). Methods Altogether 1900patients were examined by MDCT from December 2007 to May 2009, of whom 95patients fulfilled the criteria of ACS. Those patients were divided into thediscrete plaque group ( n=61) anddiffuse plaque group ( n=34) based onthe findings in MDCT. The clinical diagnosis of ACS and CT results wereanalyzed, including segment stenosis score, segment involvement score, 3-vesselplaque score, left main score, calcification score, and remodeling index. Theincidences of major adverse cardiac events in follow-up period were alsorecorded.ResultsThe patients of the diffuse plaque groupwere older than those of the discrete plaque group ( P<0.0001). The diffuse plaque grouppresented more cases of hypertension, peripheral artery disease, diabetes, and heart failure than discrete plaque group (all P<0.05). All the 5 patients with ST-segment elevation myocardialinfarction were found in discrete plaque group. The segment stenosis score ofthe discrete plaque group was lower than that of the diffuse plaque group(5.15±3.55 vs. 14.91±5.37, P<0.001). The other four scores demonstrated significant inter-group difference as well (all P<0.05). The remodeling index of thediscrete plaque group was higher (1.12±0.16 vs.0.97±0.20, P<0.05). Follow-up data showed that major adverse cardiac eventsoccurred more frequently in diffuse plaque group than in discrete group (29.41% vs. 11.48%, P=0.0288).Conclusions Characteristics of discrete and diffuseplaques may be significantly different among different classes of ACS. Thediffuse plaque may present higher risk, correlated to higher mortality. Thediagnosis of discrete and diffuse plaques by MDCT would provide a new insightinto the prognosis and treatment of ACS.

Key words: acute coronary syndrome, coronary plaque, multi-detector CT

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