Chinese Medical Sciences Journal ›› 2022, Vol. 37 ›› Issue (2): 118-126.doi: 10.24920/003901

• 论著 • 上一篇    下一篇

短疗程睑缘清洁联合抗生素滴眼液的使用对白内障术前眼表菌群抑制作用的临床研究

陈晓勇,蔡宏媛,刘忆南,洪晶*()   

  1. 北京大学第三医院眼科中心,北京 100191
  • 收稿日期:2021-03-21 接受日期:2022-02-16 出版日期:2022-06-30 发布日期:2022-07-07
  • 通讯作者: 洪晶 E-mail:hongjing196401@163.com

Inhibitory Effect of Short-Term Palpebral Margin Cleaning with Antibiotic Eye Drops on Ocular Surface Flora before Cataract Extraction: A New Preoperative Antibacterial Method

Xiaoyong Chen,Hongyuan Cai,Yinan Liu,Jing Hong*()   

  1. Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China
  • Received:2021-03-21 Accepted:2022-02-16 Published:2022-06-30 Online:2022-07-07
  • Contact: Jing Hong E-mail:hongjing196401@163.com

摘要:

目的 探讨睑缘清洁与抗生素滴眼液的联合使用对白内障患者术前睑缘和结膜囊细菌抑制作用的临床效果。
方法 收集于北京大学第三医院拟行超声乳化白内障吸除联合人工晶体植入术的年龄相关性白内障患者61例(97只眼)。试验组术前3 d滴用左氧氟沙星眼液并联合使用睑缘清洁棉片;对照组术前3 d滴用左氧氟沙星滴眼液。试验组和对照组均在采取抗菌措施前、采取抗菌措施3 d后2个时间点对术眼睑缘、结膜囊分别取材进行细菌培养及鉴定。
结果 试验组在使用抗菌措施前睑缘和结膜囊细菌培养阳性率分别为100%(50/50)和40%(20/50);采用抗菌措施3d后分别为10%(5/50)和0%(0/50)。对照组在使用抗菌措施前睑缘和结膜囊细菌培养阳性率分别为97.9%(46/47)和29.8%(14/47);采用抗菌措施3d后分别为40.4%(19/47)和10.6%(5/47)。采用抗菌措施前试验组和对照组睑缘和结膜囊细菌培养阳性率差异无统计学意义(P值分别为0.485和0.395),采用抗菌措施后差异有统计学意义(P值分别为0.001和0.024)。
结论 白内障摘除术前,抗生素滴眼液联合睑缘清洁棉片对睑缘和结膜囊有良好的抑菌效果。此外,这种联合清洁棉片的术前抗菌方法可以在保留良好抗菌效果的同时有效减少术前抗生素药物的使用。

关键词: 抗生素预防, 白内障摘除术, 眼睑清洁, 微生物群

Abstract:

Objective To explore the clinical significance of the combined application of palpebral margin cleaning and antibiotic eye drops in inhibiting bacterial growth in the palpebral margin and conjunctival sacs before cataract extraction.
Methods In this study, 61 patients (97 eyes) with age-related cataract who underwent phacoemulsification and intraocular lens implantation were selected, and randomly grouped. In the experimental group, the combined application of palpebral margin cleaning with cotton pads and levofloxacin eye drops was given for three days before the surgery. In the control group, levofloxacin eye drops alone were applied for three consecutive days. Bacteria samples from the conjunctival sac and eyelid margins were cultivated and identified before and three days after taking antimicrobial measures, respectively.
Results In the experimental group, the positive rates of the two bacteria samples were 100% (50/50) and 40% (20/50) before and 10% (5/50) and 0% (0/50) after the treatment. In the control group, the positive rates of the two bacteria samples were 97.9% (46/47) and 29.8% (14/47) before and 40.4% (19/47) and 10.6% (5/47) after the treatment. The positive rates between the two groups were not significantly different before taking antimicrobial measures (P= 0.485 and 0.395), while they were significantly different after taking antimicrobial measures (P = 0.001 and 0.024).
Conclusion Combined application of eyelid and palpebral margin cleaning with cotton pads and antibiotic eye drops before cataract extraction imparted excellent antibacterial effects.

Key words: antibiotic prophylaxis, cataract extraction, eyelid cleaning, microbiota

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