大麻素CB1受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

doi:10.24920/004087

Chinese Medical Sciences Journal ›› 2023, Vol. 38 ›› Issue (1): 29-37.doi: 10.24920/004087

大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

Kaveh Shahveisi¹,Seyedeh Marziyeh Hadi²,Hamed Ghazvini^3,⁴,Mehdi Khodamoradi^5,^*()

¹克尔曼沙阿医科大学睡眠障碍研究中心，克尔曼沙阿，伊朗
²克尔曼沙阿医科大学医学院，克尔曼沙阿，伊朗
³马赞达兰医科大学成瘾研究所精神病学和行为科学研究中心，萨里，伊朗
⁴马赞达兰医科大学医学先进技术学院神经科学系，萨里，伊朗
⁵克尔曼沙阿医科大学卫生研究所药物滥用预防研究中心，克尔曼沙阿，伊朗

收稿日期:2022-03-21 接受日期:2022-09-06 出版日期:2023-03-31 发布日期:2023-02-28
通讯作者: Mehdi Khodamoradi E-mail:mehdi0khodamoradi@gmail.com

Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats

Kaveh Shahveisi¹,Seyedeh Marziyeh Hadi²,Hamed Ghazvini^3,⁴,Mehdi Khodamoradi^5,^*()

¹Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah 6719851451, Iran
²Faculty of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6714869914, Iran
³Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari 48175866, Iran
⁴Department of Neuroscience, School of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari 48175866, Iran
⁵Substance Abuse Prevention Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah 6719851451, Iran

Received:2022-03-21 Accepted:2022-09-06 Published:2023-03-31 Online:2023-02-28
Contact: Mehdi Khodamoradi E-mail:mehdi0khodamoradi@gmail.com

摘要/Abstract

摘要：

目的探讨大麻素CB1受体（cannabinoid CB1 receptor，CB1R）的拮抗作用是否会影响慢性快速眼动（chronically rapid eye movement，CRM）睡眠剥夺（CRM sleep-deprived，RSD）大鼠的新物体识别（novel object recognition，NOR）记忆。

方法采用多平台技术对动物进行为期7天的慢性部分RSD范式的识别记忆检查。CB₁R拮抗剂利莫那班（1mg/kg或3mg/kg，腹腔内注射）在记忆获取采样前一小时、在记忆巩固采样后即时或在NOR记忆提取测试阶段前至少一小时进行注射。为实现记忆再巩固，在第二个采样阶段完成后即时注射利莫那班。

结果 RSD损害了NOR记忆的获取、巩固和提取，但不影响NOR记忆的再巩固。注射利莫那班不影响记忆的获取、巩固和再巩固；然而，它减轻了慢性RSD对NOR记忆提取造成的损害。

结论这些发现以及我们之前的报告似乎表明，RSD可能因其持续时间不同而影响识别记忆的不同阶段。重要的是，CB1R似乎至少部分参与了慢性RSD对NOR记忆的提取，但与NOR记忆的获取、巩固和再巩固无关。

关键词: 快速眼动睡眠剥夺, 新物体识别记忆, 大麻素CB¹受体, 利莫那班

Abstract:

Objective We aimed to investigate whether antagonism of the cannabinoid CB₁ receptor (CB₁R) could affect novel object recognition (NOR) memory in chronically rapid eye movement sleep-deprived (RSD) rats.

Methods The animals were examined for recognition memory following a 7-day chronic partial RSD paradigm using the multiple platform technique. The CB₁R antagonist rimonabant (1 or 3 mg/kg, i.p.) was administered either at one hour prior to the sample phase for acquisition, or immediately after the sample phase for consolidation, or at one hour before the test phase for retrieval of NOR memory. For the reconsolidation task, rimonabant was administered immediately after the second sample phase.

Results The RSD episode impaired acquisition, consolidation, and retrieval, but it did not affect the reconsolidation of NOR memory. Rimonabant administration did not affect acquisition, consolidation, and reconsolidation; however, it attenuated impairment of the retrieval of NOR memory induced by chronic RSD.

Conclusions These findings, along with our previous report, would seem to suggest that RSD may affect different phases of recognition memory based on its duration. Importantly, it seems that the CB₁R may, at least in part, be involved in the adverse effects of chronic RSD on the retrieval, but not in the acquisition, consolidation, and reconsolidation, of NOR memory.

Key words: REM sleep deprivation, novel object recognition memory, cannabinoid CB₁ receptor, rimonabant

Kaveh Shahveisi, Seyedeh Marziyeh Hadi, Hamed Ghazvini, Mehdi Khodamoradi. Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats[J].Chinese Medical Sciences Journal, 2023, 38(1): 29-37.

图/表 6

参考文献 43

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Groups	Time spent exploring objects during the sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	27.54 ± 2.64	21.52 ± 3.03	10.64 ± 1.33	32.40 ± 3.38***
RSD	24.80 ± 2.50	19.41 ± 2.16	18.19 ± 3.07	20.63 ± 2.99
RSD-Veh	23.45 ± 2.52	17.96 ± 2.21	17.08 ± 3.53	18.85 ± 2.62
RSD-R 1 mg/kg	24.27 ± 2.49	19.18 ± 2.14	18.69 ± 2.99	19.67 ± 3.06
RSD-R 3 mg/kg	23.18 ± 2.56	20.23 ± 2.21	17.60 ± 1.88	22.85 ± 3.83

Groups	Time spent exploring objects during the sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	26.98 ± 2.36	21.34 ± 3.05	10.27 ± 1.85	32.40 ± 3.07***
RSD	23.26 ± 2.38	20.32 ± 2.02	16.78 ± 1.74	23.86 ± 3.25
RSD-Veh	25.21 ± 2.72	18.49 ± 2.26	15.96 ± 2.50	21.02 ± 3.58
RSD-R 1 mg/kg	24.01 ± 2.22	20.61 ± 2.02	16.94 ± 1.80	24.27 ± 3.23
RSD-R 3 mg/kg	24.61 ± 2.43	19.40 ± 1.87	16.25 ± 1.69	22.54 ± 3.04*

Groups	Time spent exploring objects during the sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	28.37 ± 2.58	22.77 ± 3.58	10.97 ± 1.77	34.56 ± 3.67**
RSD	24.12 ± 2.91	18.58 ± 2.01	15.98 ± 1.72	21.17 ± 3.42
RSD-Veh	24.41 ± 2.52	19.33 ± 1.92	17.10 ± 2.00	21.57 ± 3.12
RSD-R 1 mg/kg	23.05 ± 2.70	20.28 ± 2.17	15.96 ± 1.90	24.61 ± 3.39*
RSD-R 3 mg/kg	22.91 ± 2.32	20.57 ± 2.20	16.07 ± 2.07	25.07 ± 3.32**

Groups	Time spent exploring objects during the 1^st sample phase (s)	Time spent exploring objects during the 2^nd sample phase (s)	Time spent exploring both objects during the test phase (s)	Time spent exploring familiar object during the test phase (s)	Time spent exploring novel object during the test phase (s)
WP	26.61 ± 2.72	22.94 ± 2.41	24.34 ± 3.24	12.23 ± 1.93	36.45 ± 2.99
RSD	24.99 ± 2.23	23.38 ± 2.31	22.36 ± 2.78	15.61 ± 2.60	29.11 ± 3.75
RSD-Veh	24.86 ± 2.69	23.22 ± 2.18	22.18 ± 2.47	16.91 ± 2.68	27.44 ± 3.33
RSD-R 1 mg/kg	25.05 ± 2.37	23.67 ± 2.38	23.51 ± 2.77	17.88 ± 2.38	29.14 ± 4.33
RSD-R 3 mg/kg	25.44 ± 2.37	22.65 ± 1.90	23.82 ± 2.79	17.88 ± 3.18	29.76 ± 3.74

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大麻素CB₁受体在慢性REM睡眠剥夺大鼠物体识别记忆受损中的作用

Role of Cannabinoid CB₁ Receptor in Object Recognition Memory Impairment in Chronically Rapid Eye Movement Sleep-deprived Rats

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